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静岡県立大学教員データベース


教員情報詳細


写真:佐藤 秀行

氏名
佐藤 秀行(SATO Hideyuki)
出生年月
1985年8 月
所属・職名
薬学部薬学科(薬剤学分野) 准教授
薬学研究院(薬剤学教室) 准教授(兼務)
電話番号
054-264-5634
部屋番号
薬学部棟6106号室
Eメールアドレス
h.sato@u-shizuoka-ken.ac.jp
ホームページアドレス(URL)
https://w3pharm.u-shizuoka-ken.ac.jp/yakuzai/

学歴

2008年3月 静岡県立大学薬学部卒業
2010年3月 静岡県立大学大学院薬学研究科博士前期課程修了

学位

博士(医療薬学)(静岡県立大学・2015年)

専門分野

動態制御、薬剤学

担当科目

医療系薬学実習

主要研究テーマ

  • 物性改変による薬物体内動態制御及び薬効の改善
  • 薬物動態制御による副作用回避

所属学会

日本薬学会
日本薬剤学会
日本薬物動態学会

主な経歴

2010年4月 日本新薬株式会社 創薬研究所 CMC 技術研究部 勤務
2014年4月 大阪薬科大学 製剤設計学研究室 勤務
2015年8月 静岡県立大学薬学部 助教
2019年1月 静岡県立大学薬学部 講師
2020年6月 静岡県立大学薬学部 准教授

主な社会活動

 

主要研究業績

○学術論文
  1. Halder S, Suzuki H, Seto Y, Sato H, Onoue S. [Megestrol acetate-loaded self-micellizing solid dispersion system for improved oral absorption and reduced food effect.] J Drug Deliv Sci Technol. In press (2019)
  2. Iyama Y, Sato H, Seto Y, Onoue S. [Photochemical and pharmacokinetic characterization of orally administered chemicals to evaluate phototoxic risk] J Pharm Sci. In press (2018)
  3. Yakushiji K., Ogino M., Suzuki H., Seyo Y., Sato H., Onoue S. [Physicochemical and biopharmaceutical characterization of celecoxib nanoparticle: Avoidance of delayed oral absorption caused by impaired gastric motility] Int J Pharm. 552(1–2):453–459 (2018)
  4. Halder S, Ogino M, Seto Y, Sato H, Onoue S. [Improved biopharmaceutical properties of carvedilol employing α-tocopheryl polyethylene glycol 1000 succinate-based self-emulsifying drug delivery system.] Drug Dev Ind Pharm. 44(11):1838–1844 (2018)
  5. Seto Y, Morizane C, Ueno K, Sato H, Onoue S. [Supersaturable Self-Emulsifying Drug Delivery System of Krill Oil with Improved Oral Absorption and Hypotriglyceridemic Function] J Agric Food Chem. 66(21):5352–5358 (2018)
  6. Kojo Y, Suzuki H, Kato K, Kaneko Y, Yuminoki K, Hashimoto N, Sato H, Seto Y, Onoue S. [Enhanced biopharmaceutical effects of tranilast on experimental colitis model with use of self-micellizing solid dispersion technology.] Int J Pharm. 24;545(1–2):19–26 (2018)
  7. Halder S, Tabata A, Seto Y, Sato H, Onoue S. [Amorphous solid dispersions of carvedilol along with pH-modifiers improved pharmacokinetic properties under hypochlorhydoria.] Biopharm Drug Dispos. 39(4):232–242 (2018)
  8. Abe O, Ono T, Sato H, Müller F, Ogata H, Miura I, Shikama Y, Yabe H, Onoue S, Fromm MF, Kimura J, Misaka S. [Role of (-)-epigallocatechin gallate in the pharmacokinetic interaction between nadolol and green tea in healthy volunteers.] Eur J Clin Pharmacol. 74(6):775–783 (2018)
  9. Suzuki H, Mizumoto T, Seto Y, Sato H, Onoue S. [Respirable powder formulation of a shortened vasoactive intestinal peptide analog for treatment of airway inflammatory diseases.] J Pept Sci. 24(3). (2018)
  10. Misaka S, Abe O, Sato H, Ono T, Shikama Y, Onoue S, Yabe H, Kimura J. [Lack of pharmacokinetic interaction between fluvastatin and green tea in healthy volunteers.] Eur J Clin Pharmacol. 74(5):601–609 (2018)
  11. Kojo Y, Kobayashi K, Matsunaga S, Suzuki H, Seto Y, Sato H, Onoue S. [Avoidance of food effect on oral absorption profile of itraconazole by self-micellizing solid dispersion approach.] Drug Metab Pharmacokinet. 32(5):273–276 (2017)
  12. Ogino M, Yakushiji K, Suzuki H, Shiokawa K, Kikuchi H, Seto Y, Sato H, Onoue S. [Enhanced pharmacokinetic behavior and hepatoprotective function of ginger extract-loaded supersaturable self-emulsifying drug delivery systems] J Funct Foods., 40:156–163 (2018)
  13. Onoue S, Seto Y, Sato H, Nishida H, Hirota M, Ashikaga T, Api AM, Basketter D, Tokura Y. [Chemical photoallergy: photobiochemical mechanisms, classification, and risk assessments.] J. Dermatol Sci, 85(1):4–11, Review (2017)
  14. Kato M, Ohtake H, Sato H, Seto Y, Onoue S. [Enzymatic reactive oxygen species assay to evaluate phototoxic risk of metabolites.] Toxicol. Lett., 278:59–65 (2017)
  15. Sato H, Aoki A, Tabata A, Kadota K, Tozuka Y, Seto Y, Onoue S. [Development of sesamin-loaded solid dispersion with α-glycosylated stevia for improving physicochemical and nutraceutical properties] J Funct Foods., 35: 325–331 (2017)
  16. Suzuki H, Yakushiji K, Matsunaga S, Yamauchi Y, Seto Y, Sato H, Onoue S. [Amorphous Solid Dispersion of Meloxicam Enhanced Oral Absorption in Rats With Impaired Gastric Motility.] J Pharm Sci., S0022-3549(17)30380–30385 (2017)
  17. Kojo Y, Matsunaga S, Suzuki H, Taniguchi C, Kawabata Y, Wada K, Yamauchi Y, Seto Y, Sato H, Onoue S. [Improved Dissolution of Dipyridamole with the Combination of pH-Modifier and Solid Dispersion Technology.] Chem Pharm Bull., 65(5): 426–431 (2017)
  18. Seto Y, Kato K, Tsukada R, Suzuki H, Kaneko Y, Kojo Y, Sato H, Onoue S. [Protective effects of tranilast on experimental colitis in rats.] Biomed Pharmacother., 90:842–849 (2017)
  19. Sato H, Ogino M, Yakushiji K, Suzuki H, Shiokawa KI, Kikuchi H, Seto Y, Onoue S. [Ginger Extract-Loaded Solid Dispersion System with Enhanced Oral Absorption and Antihypothermic Action.] J Agric Food Chem., 65(7):1365–1370 (2017)
  20. Kojo Y, Matsunaga S, Suzuki H, Taniguchi C, Kawabata Y, Wada K, Yamauchi Y, Seto Y, Sato H, Onoue S. [Improved Dissolution of Dipyridamole with the Combination of pH-Modifier and Solid Dispersion Technology] Chem Pharm Bull., 65:1–7 (2017)
  21. Suzuki H, Moritani T, Morinaga T, Seto Y, Sato H, Onoue S. [Amorphous solid dispersion of cyclosporine A prepared with fine droplet drying process: Physicochemical and pharmacokinetic characterization.] Int J Pharm., 519(1–2):213–219 (2017)
  22. Suzuki H, Hamao S, Seto Y, Sato H, Wong J, Prud'homme RK, Chan HK, Onoue S. [New nano-matrix oral formulation of nanoprecipitated cyclosporine A prepared with multi-inlet vortex mixer.] Int J Pharm., 516(1–2):116–119 (2017)
  23. Kojo Y, Matsunaga S, Suzuki H, Sato H, Seto Y, Onoue S. [Improved oral absorption profile of itraconazole in hypochlorhydria by self-micellizing solid dispersion approach.] Eur J Pharm Sci., 97:55–61 (2017)
  24. Suzuki H, Ueno K, Mizumoto T, Seto Y, Sato H, Onoue S. [Self-micellizing solid dispersion of cyclosporine A for pulmonary delivery: Physicochemical, pharmacokinetic and safety assessments.] Eur J Pharm Sci., 96:107–114 (2017)
  25. Nihei T, Suzuki H, Aoki A, Yuminoki K, Hashimoto N, Sato H, Seto Y, Onoue S. [Development of a novel nanoparticle formulation of thymoquinone with a cold wet-milling system and its pharmacokinetic analysis.] Int J Pharm., 511(1):455–461 (2016)
  26. Kadota K, Okamoto D, Sato H, Onoue S, Otsu S, Tozuka Y. [Hybridization of polyvinylpyrrolidone to a binary composite of curcumin/α-glucosyl stevia improves both oral absorption and photochemical stability of curcumin] Food Chem., 213: 668–674 (2016)
  27. Sato H, Suzuki H, Yakushiji K, Wong J, Seto Y, Prud’homme RK, Chan HK, Onoue S. [Biopharmaceutical evaluation of novel cyclosporine A nano-matrix particles for inhalations,] Pharm Res., 33(9): 2107–2116 (2016)
  28. Kadota K., Semba K., Shakudo R., Sato H., Deki Y., Shirakawa Y., Tozuka Y. [Inhibition of Photodegradation of Highly Dispersed Folic Acid Nanoparticles by the Antioxidant Effect of Transglycosylated Rutin] J Agric Food Chem., 64(15) 3062-9 (2016)
  29. Fujimori M., Kadota K., Kato K., Seto Y., Onoue S., Sato H., Ueda H., Tozuka Y. [Low hygroscopic spray-dried powders with trans-glycosylated food additives for the enhanced solubility and oral bioavailability of a hydrophobic flavone] Food Chem., 190:1050-1055 (2016)
  30. Kadota K., Ehara M., Fujimori M., Sato H., Tozuka Y. [Quantification of the amorphous content of ursodeoxycholic acid by pulsed NMR] J Pharm Sci Technol, Jpn., 76(2):117-122 (2016)
  31. Tanida S, Kurokawa T, Sato H, Kadota K, Tozuka Y. [Evaluation for micellization mechanism of an amphipathic graft copolymer with enhanced solubility of ipriflavoner] Chem Pharm Bull., 64:68-72 (2016)
  32. Kadota K., Otsu S., Fujimori M., Sato H., Tozuka Y. [Soluble hydrolysis-resistant composite formulation of curcumin containing -glucosyl hesperidin and polyvinylpyrrolidone] Advanced powder Technology, 27:442-447 (2016)
  33. Sato H, Fujimori M, Suzuki H, Kadota K, Shirakawa Y, Onoue S, Tozuka Y [Absorption improvement of tranilast by forming highly soluble nano-size composite structures associated with -glucosyl rutin via spray drying.] Eur J Pharm Biopharm.., 92:49-55 (2015)
  34. Sato H, Ogawa K, Kojo Y, Suzuki H, Mizumoto T, Onoue S [Physicochemical stability study on cyclosporine A loaded dry-emulsion formulation with enhanced solubility.] Chem pharm bull., 63:54-58 (2015)
  35. Fujimori M, Kadota K, Shimono K, Shirakawa Y, Sato H, Tozuka Y [Enhanced solubility of quercetin by forming composite particles with transglycosylated materials.] J Food Engineering., 149:248–254 (2015)
  36. Onoue S, Suzuki H, Kojo Y, Matsunaga S, Sato H, Mizumoto T, Yuminoki K, Hashimoto N, Yamada S. [Self-micellizing solid dispersion of cyclosporine A with improved dissolution and oral bioavailability.] Eur J Pharm Sci., 62:16-22 (2014)
  37. Sato H, Ogawa K, Kojo Y, Kawabata Y, Mizumoto T, Yamada S, Onoue S [Development of cyclosporine A-loaded dry-emulsion formulation using highly purified glycerol monooleate for safe inhalation therapy.] Int J Pharm., 448:282-9 (2013)
  38. Sato H, Kawabata Y, Yuminoki K, Hashimoto N, Yamauchi Y, Ogawa K, Mizumoto T, Yamada S, Onoue S. [Comparative studies on physicochemical stability of cyclosporine A-loaded amorphous solid dispersions.] Int J Pharm., 426:302-6 (2012)
  39. Onoue S, Sato H, Ogawa K, Kojo Y, Aoki Y, Kawabata Y, Wada K, Mizumoto T, Yamada S. [Inhalable dry-emulsion formulation of cyclosporine A with improved anti-inflammatory effects in experimental asthma/COPD-model rats.] Eur J Pharm Biopharm., 80:54-60 (2012)
  40. Kawabata Y, Aoki Y, Matsui T, Yamamoto K, Sato H, Onoue S, Yamada S [Stable dry powder inhaler formulation of tranilast attenuated antigen-evoked airway inflammation in rats.] Eur J Pharm Biopharm., 77:178-81 (2011)
  41. Misaka S, Sato H, Aoki Y, Mizumoto T, Onoue S, Yamada S [Novel vasoactive intestinal peptide derivatives with improved stability protect rat alveolar L2 cells from cigarette smoke-induced cytotoxicity and apoptosis.] Peptides., 32:401-7 (2011)
  42. Onoue S, Sato H, Ogawa K, Kawabata Y, Mizumoto T, Yuminoki K, Hashimoto N, Yamada S [Improved dissolution and pharmacokinetic behavior of cyclosporine A using high-energy amorphous solid dispersion approach.] Int J Pharm., 399:94-101 (2010)
  43. Onoue S, Aoki Y, Kawabata Y, Matsui T, Yamamoto K, Sato H, Yamauchi Y, Yamada S [Development of inhalable nanocrystalline solid dispersion of tranilast for airway inflammatory diseases.] J Pharm Sci., 100:622-33 (2011)
  44. Hatanaka J, Chikamori H, Sato H, Uchida S, Debari K, Onoue S, Yamada S [Physicochemical and pharmacological characterization of alpha-tocopherol-loaded nano-emulsion system.] Int J Pharm., 396:188-93 (2010)
  45. Misaka S, Sato H, Yamauchi Y, Onoue S, Yamada S [Novel dry powder formulation of ovalbumin for development of COPD-like animal model: Physicochemical characterization and biomarker profiling in rats.] Eur J Pharm Sci., 37:469-76 (2009)
  46. Onoue S, Misaka S, Ohmori Y, Sato H, Mizumoto T, Hirose M, Iwasa S, Yajima T, Yamada S [Physicochemical and pharmacological characterization of novel vasoactive intestinal peptide derivatives with improved stability.] Eur J Pharm Biopharm., 73:95-101 (2009)
  47. Onoue S, Sato H, Kawabata Y, Mizumoto T, Hashimoto N, Yamada S [In vitro and in vivo characterization on amorphous solid dispersion of cyclosporine A for inhalation therapy.] J Control Release., 138:16-23 (2009)

教育・研究に対する考え方

教育:「考える力」を養えるような教育に傾注したい。詰め込み型の学習ではなく、実際に現場でも臨機応変に対応できる研究者・医療従事者の育成を目指す。
研究:新規製剤技術を DDS のツールとして用いた動態制御に関する研究に注力したい。これによって、医薬品開発の促進や医薬品のライフサイクルマネジメント等に貢献する研究成果が期待でき、企業との産学連携をより促進できるものと考える。

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