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静岡県立大学教員データベース


教員情報詳細


写真:小出 裕之

氏名
小出 裕之(KOIDE Hiroyuki)
出生年月
1983年8月
所属・職名
薬学部薬学科(医薬生命化学分野) 講師
薬学研究院(医薬生命化学教室) 講師(兼務)
電話番号
054-264-5701
部屋番号
薬学部棟6415教室
Eメールアドレス
hkoide@u-shizuoka-ken.ac.jp
ホームページアドレス(URL)
https://w3pharm.u-shizuoka-ken.ac.jp/radiobio/
研究シーズ集
https://www.u-shizuoka-ken.ac.jp/media/seeds2019-2020_012.pdf

学歴

2006年3月 城西大学薬学部薬学科卒業
2011年3月 静岡県立大学大学院薬学研究科博士課程修了

学位

博士(薬学)(静岡県立大学・2011年)

専門分野

薬物送達学、高分子化学

担当科目

生物化学I、放射化学、生物学入門

主要研究テーマ

  • がん治療に向けた高分子ナノゲルの開発
  • 新規抗腫瘍DDS製剤の開発

所属学会

日本薬学会
日本薬剤学会
日本DDS学会
日本生化学会
高分子学会
American Chemistry Society

主な経歴

2010年4月 日本学術振興会特別研究員
2011年4月 カリフォルニア大学アーバイン校化学科 博士研究員
2013年4月 日本学術振興会海外特別研究員
2014年1月 静岡県立大学薬学部 助教
2018年10月 静岡県立大学薬学部 講師

受賞歴

2016年、2017年 生化学会中部支部 奨励賞
2018年 日本DDS学会 奨励賞(基礎)
2018年 第28回バイオ・高分子シンポジウム若手講演賞
2019年 日本薬学会 奨励賞
2020年 日本薬学会東海支部 奨励賞

主な社会活動

 

主要研究業績

○原著論文
  1. Koide H, Hirano S, Ide T, Saito K, Suzuki H, Yasuno G, Hamashima Y, Yonezawa Y, Oku N, Asai T., Engineering of Lipid Nanoparticles by the Multifunctionalization of the Surface with Amino Acid Derivatives for the Neutralization of a Target Toxic Peptide. Adv Funct Mater., 2020 In press
  2. Yonezawa S, Koide H, Asai T., Recent advances in siRNA delivery mediated by lipid-based nanoparticles. Adv Drug Deliv Rev. 2020, In press
  3. Hirai Y, Saeki R, Song F, Koide H, Fukata N, Tomita K, Maeda N, Oku N, Asai T., Charge-reversible lipid derivative: A novel type of pH-responsive lipid for nanoparticle-mediated siRNA delivery. Int J Pharm. 585, 119479, 2020
  4. Kikuchi T, Fukuta T, Agato Y, Yanagida Y, Ishii T, Koide H, Shimizu K, Oku N, Asai T., Suppression of cerebral ischemia/reperfusion injury by efficient release of encapsulated ifenprodil from liposomes under weakly acidic pH conditions. J Pharm Sci. 108, 3823-3830, 2019
  5. Koide H, Fukuta T, Okishima A, Ariizumi S, Kiyokawa C, Tsuchida H, Nakamoto M, Yoshimatsu K, Ando H, Dewa T, Asai T, Oku N, Hoshino Y, Shea KJ., Engineering the Binding Kinetics of Synthetic Polymer Nanoparticles for siRNA Delivery. Biomacromolecules. 20, 3648-3657, 2019
  6. Zang L, Shimada Y, Nakayama H, Chen W, Okamoto A, Koide H, Oku N, Dewa T, Shiota M, Nishimura N., Therapeutic Silencing of Centromere Protein X Ameliorates Hyperglycemia in Zebrafish and Mouse Models of Type 2 Diabetes Mellitus. Front Genet. 10, 693, 2019
  7. Sako M, Song F, Okamoto A, Koide H, Dewa T, Oku N, Asai T., Key determinants of siRNA delivery mediated by unique pH-responsive lipid-based liposomes. Int J Pharm. 569, 118606, 2019
  8. Song F, Sakurai N, Okamoto A, Koide H, Oku N, Dewa T, Asai T., Design of a Novel PEGylated Liposomal Vector for Systemic Delivery of siRNA to Solid Tumors. Biol Pharm Bull. 42, 996-1003, 2019
  9. Okishima A, Koide H*, Hoshino Y, Egami H, Hamashima Y, Oku N, Asai T., Design of Synthetic Polymer Nanoparticles Specifically Capturing Indole, a Small Toxic Molecule. Biomacromolecules. 4, 1644-1654, 2019 *Correspond Author
  10. Okamoto A, Koide H, Morita N, Hirai Y, Kawato Y, Egami H, Hamashima Y, Asai T, Dewa T, Oku N., Rigorous control of vesicle-forming lipid pKa by fluorine-conjugated bioisosteres for gene-silencing with siRNA. J. Control Release. 295, 87-92. 2019
  11. Koide H, Yoshimatsu K, Hoshino Y, Ariizumi S, Okishima A, Ide T, Egami H, Hamashima Y, Nishimura Y, Kanazawa H, Miura Y, Asai T, Oku N, Shea KJ., Sequestering and inhibiting a vascular endothelial growth factor in vivo by systemic administration of a synthetic polymer nanoparticle., J. Control Release. 295, 13-20. 2019
  12. Okamoto A, Asai T, Hirai Y, Shimizu K, Koide H, Minamino T, Oku N., Systemic Administration of siRNA with Anti-HB-EGF Antibody-Modified Lipid Nanoparticles for the Treatment of Triple-Negative Breast Cancer., Mol Pharm., 4, 1495-1504, 2018
  13. Koide H, Tsuchida H, Nakamoto M, Okishima A, Ariizumi S, Kiyokawa C, Asai T, Hoshino Y, Oku N, Rational designing of an antidote nanoparticle decorated with abiotic polymer ligands for capturing and neutralizing target toxins, J Control Release, 268, 335-342, 2017
  14. Koide H, Yoshimatsu K, Hoshino Yu, Lee S, Okajima A, Ariizumi S, Narita Y, Yonamine Y, Weisman A C, Nishimura Y, Oku N, Miura Y, and Shea KJ, A Polymer Nanoparticle with Engineered Affinity for a Vascular Endothelial Growth Factor (VEGF165), Nature Chemistry, 9, 715–722, 2017
  15. Fukuta T, Asai T, Yanagida Y, Namba M, Koide H, Shimizu K and Oku N, Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke, FASEB J., 5, 1879-1890, 2017
  16. Fukuta T, Asai T, Ishii T, Koide H, Kiyokawa C, Hashimoto M, Kikuchi T, Shimizu K, Harada N, Tsukada H, Oku N, Non-invasive evaluation of neuroprotective drug candidates for cerebral infarction by PET imaging of mitochondrial complex-I activity, Sci Rep., 6, 30127, 2016
  17. Fukuta T, Asai T, Sato A, Namba M, Yanagida Y, Kikuchi T, Koide H, Shimizu K, Oku N, Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil. Int J Pharm., 506, 129-137. 2016.
  18. Koide H, Okamoto A, Tsuchida H, Ando H, Ariizumi S, Kiyokawa C,Hashimoto M, Asai T, Dewa T, Oku N, One-step encapsulation of siRNA between lipid-layers of multi-layer polycation liposomes by lipoplex freeze-thawing, J Control Release, 228, 1-8, 2016
  19. Waki N, Kuwabara Y, Yoshikawa Y, Suganuma H, Koide H, Oku N, Ohashi N, Amelioration of Citrobacter rodentium proliferation in early stage of infection in mice by pretreatment with Lactobacillus brevis KB290 and verification using in vivo bioluminescence imaging, FEMS Microbiol Lett., 364, 6, 2017.
  20. Yoshimatsu K, Koide H, Hoshino Y, Shea KJ, Preparation of abiotic polymer nanoparticles for sequestration and neutralization of a target peptide toxin, Nature Protocols, 4, 595-604, 2015.
  21. Koide H, Asai T, Kato H, Yonenaga N, Yokota M, Ando H, Dewa T, Nango M, Maeda N, Oku N, Susceptibility of PTEN-positive metastatic tumors to small interfering RNA targeting the mammalian target of rapamycin, Nanomedicine, 1, 185-194, 2015.
  22. Ando H, Asai T, Koide H, Okamoto A, Maeda N, Tomita K, Dewa T, Minamino T, Oku N., Advanced cancer therapy by integrative antitumor actions via systemic administration of miR-499, J Control Release, 181, 32-39, 2014
  23. Ando H, Yonenaga N, Asai T, Hatanaka K, Koide H, Tsuzuku T, Harada N, Tsukada H, Oku N., In vivo imaging of liposomal small interfering RNA (siRNA) trafficking by positron emission tomography.,Yakugaku Zasshi, 132,1373-1381, (2012)
  24. Siripong P, Yahuafai J, Piyaviriyakul S, Kanokmedhakul K, Koide H, Ishii T, Shimizu K, Ruchirawat S, Oku N., Inhibitory effect of liposomal rhinacanthin-N isolated from Rhinacanthus nasutus on pulmonary metastasis in mice., Biol Pharm Bull., 35, 1197-1200, (2012)
  25. Koide H, Asai T, Kato H, Ando H, Shiraishi K, Yokoyama M, Oku N., Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles., Int J Pharm., 432,75-79, (2012).
  26. Hoshino Y, Koide H, Furuya K, Haberaecker W W., Lee S, Kodama T, Kanawaza H, Oku N, and Shea K J. The Rational Design of a Plastic Antidote: Synthetic Polymer Nanoparticles that Neutralize Toxic Peptides in Vivo., Proc Natl Acad Sci USA, 109, 33-38, (2012)
  27. Asai T, Matsushita S, Kenjo E, Tsuzuku T, Yonenaga N, Koide H, Hatanaka K, Dewa T, Nango M, Maeda N, Kikuchi H, and Oku N,.Dicetylphosphate-tetra ethylenepentamine-based Liposomes for Systemic siRNA Delivery., Bioconjug Chem., 22, 429-435, (2011)
  28. Koide H Asai T, Furuya K, Tsuzuku T, Kato H, Dewa T, Nango M, Maeda N, and Oku N., Inhibition of Akt (ser473) phosphorylation and rapamycin-resistant cell growth by mammalian target of rapamycin knockdown with siRNA in VEGFR-1 targeting vector., Biol. Pharm. Bull. 34, 602-608, (2011)
  29. Asakawa T, Hiza A, Nakayama M, Inai M, Oyama D, Koide H, Shimizu K, Wakimoto T, Harada N, Tsukada H, Oku N and Kan T., PET imaging of nobiletin based on a practical total synthesis., Chem. Commun. (Camb). 47. 2868-2870, (2011)
  30. Koide H, Asai T, Hatanaka K, Akai S, Ishii T, Kenjo E, Ishida T, Kiwada H, Tsukada H and Naoto O., T cell-independent B cell response is responsible for ABC phenomenon induced by repeatedinjection of PEGylated liposomes., Int. J. Pharm., 392, 218-223, (2010)
  31. Hoshino Y, Koide H, Urakami T, Kanazawa H, Kodama T, Oku N and Kenneth J. S., Recognition, neutralization, and clearance of target peptides in the bloodstream of living mice by molecularly imprinted polymer nanoparticles: a plastic antibody., J. Am. Chem. Soc., 132, 6644-6645, (2010)
  32. Hatanaka K, Asai T, Koide H, Kenjo E, Tsuzuku T, Harada N, Tsukada H and Oku N., Development of double-stranded siRNA labeling method using positron emitter and its in vivo trafficking analyzed by positron emission tomography., Bioconjug. Chem., 21, 756- 763, (2010)
  33. Hoshino Y, Urakami T, Kodama T, Koide H, Oku N, Okahata Y and Kenneth J. S., Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide., Small., 5, 1562-1568, (2009)
  34. Urakami T, Kawaguchi A, Akai S, Hatanaka K, Koide H, Shimizu K, Asai T, Fukumoto D, Harada N, Tsukada H and Oku N., In vivo trafficking of liposome-encapsulated hemoglobin determined by positron emission tomography., Artificial Organs., 33, 164-168. (2009)
  35. Koide H, Asai T, Hatanaka K, Urakami T, Ishii T, Kenjo E, Nishihara M, Yokoyama M, Ishida T, Kiwada H and Oku N., Particle size-dependent triggering of accelerated blood clearance phenomenon., Int. J. Pharm., 362, 197-200, (2008)
  36. Imanaka H, Koide H, Shimizu K, Asai T, Shimizu K N, Ishikado A, Makino T and Oku N., Chemoprevention of tumor metastasis by liposomal beta-sitosterol intake., Biol. Pharm. Bull., 31, 400-404, (2008)
  37. Hashimoto M, Takashige K, Furuyashiki M, Yoshidome K, Sano R, Kawamura Y, Ijichi S, Morioka H, Koide H, Oku N, Moriya Y, Kusumoto S and Suda Y., Enhancement of antitumor activity of OK-432 (Picibanil) by Triton X-114 phase partitioning., Int. Immunopharmacology., 8, 12-19, (2008)

○総説
  1. Koide H, Asai T, Shimizu K and Oku N., Drug carrier systems for anticancer agents., CRC press.
  2. Koide H, Asai T, Hatanaka K, Shimizu K, Yokoyama M, Ishida T, Kiwada H, and Oku N., Elucidation of accelerated blood clearance phenomenon causedby repeat injection of PEGylated nanocarriers., YAKUGAKU ZASSHI., Review, 129, 1445-1451, (2009)

教育・研究に対する考え方

研究:物事の原理を理解したうえで仮説を立て実証していくのが研究であり、そこに求められるのは柔軟な発想と忍耐力、そして継続力である。
教育:研究を通して自ら考え行動する大切さを伝え、自主性のある学生を育成してきたい。

研究シーズ集に関するキーワード

がん,ナノ粒子,抗体,血管新生

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