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静岡県立大学教員データベース


教員情報詳細


写真:稲井 誠

氏名
稲井 誠(INAI Makoto)
出生年月
1981年8月
所属・職名
薬学部薬学科(医薬品製造化学分野) 講師
薬学研究院(医薬品製造化学研究室) 講師(兼務)
電話番号
054-264-5741
部屋番号
薬学部棟6511号室
Eメールアドレス
makinai@u-shizuoka-ken.ac.jp
ホームページアドレス(URL)
https://www.us-yakuzo.jp/
研究シーズ集
https://www.u-shizuoka-ken.ac.jp/media/seeds2019-2020_020.pdf

学歴

2004年3月 徳島文理大学薬学部薬学科卒業
2009年3月 静岡県立大学大学院薬学研究科修了

学位

博士(薬学)(静岡県立大学・2009年)

専門分野

有機合成化学、医薬化学

担当科目

有機化学Ⅱ (機器分析)、有機化学Ⅲ、有機化学Ⅳ、化学系薬学実習、総合薬科学研究、基礎・医用工学実習

主要研究テーマ

  • 生物活性を有する天然物有機化合物の合成
  • 天然物の生合成経路解明を目的とした機能性分子の創製
  • 有用な新規合成反応の開発

所属学会

日本薬学会
有機合成化学協会

主な経歴

2009年4月 上原記念生命科学財団 海外留学ポストドクトラルフェローシップ研究員(コロラド州立大学 Robert M. Williams 研究室)
2010年4月 徳島文理大学薬学部 博士研究員
2011年4月 徳島文理大学薬学部 助教
2011年9月 静岡県立大学薬学部 助教
2016年10月 静岡県立大学薬学部 講師

主な社会活動

次世代を担う有機化学シンポジウム 世話人

主要研究業績

  • “Synthetic Study on Pactamycin and its Derivatives: Improve Synthesis of Our Route” Eur. J. Org. Chem. 2020, 488-491.
  • “Transdermal delivery of nobiletin using ionic liquids” Sci. Rep. 2019, 9, 20191.
  • “Piperidine and Azetidine Formation by Direct Cyclization of Diols with N-Nonsubstituted Sulfonamide under The Mitsunobu Conditions Utilizing (Cyanomethylene)Tributylphosphorane (CMBP) and Its Application to The Synthesis of Lupinine” Heterocycles 2019, 98, 1525–1535.
  • “Diastereodivergent and Regiodivergent Total Synthesis of Princepin and Isoprincepin in Both (7”R,8”R) and (7”S,8”S) Isomers” J. Org. Chem. 2019, 84, 14227–14240.
  • “Ribosides and Ribotide of a Fairy Chemical, Imidazole-4-carboxamide, as Its Metabolites in Rice” Org. Lett. 2019, 21, 7841–7845.
  • “A Fairy Chemical, Imidazole-4-carboxamide, is Produced on a Novel Purine Metabolic Pathway in Rice” Sci. Rep. 2019, 9, 9899.
  • “CONSICE SYNTHESIS OF TAN1251C” Heterocycles 2019, 99, 1095–1116.
  • “Practical synthesis of polymethylated flavones: nobiletin and its desmethyl derivative”. Org. Process Res. Dev. 2019, 23, 595–602.
  • “Optically Active 2,7,10,15-Tetrahydroxytetraphenylene: Clathrates with Both Enantiomers of 1-Phenylethylamine and Their Stability” Eur. J. Org. Chem. 2018, 48, 6991–6999.
  • “A role of uroleuconaphins, polyketide red pigments in aphid, as a chemopreventor in the host defense system against infection with entomopathogenic fungi” 2018, 71, 992–999.
  • “Synthesis of double-13C-labeled imidazole derivatives” Tetrahedron Lett. 2018, 59, 3516–3518.
  • “Concise synthesis of polymethoxyflavone sudachitin and its derivatives, and biological evaluations” Tetrahedron Lett. 2018, 59, 1816–1818.
  • “Total synthesis of natural products using a desymmetrization strategy” Tetrahedron Lett. 2018 59, 1343–1347.
  • “An efficient screening method for purifying and crystallizing membrane proteins using modified clear-native PAGE” Anal. Biochem. 2018, 548, 7–14.
  • “N-Glucosides of Fairy Chemicals, 2-Azahypoxanthine and 2-Aza-8-oxohypoxanthine, in Rice” Org. Lett. 2018 20, 312–314.
  • “Total Synthesis of TAN1251C via Diastereoselective Construction of the Azaspiro Skeleton” Org. Lett. 2017 19, 3839–3842.
  • “Synthetic Study on Pactamycin: Stereoselective Synthesis of the Cyclopentane Core Framework” Org. Lett. 2017, 19, 3358−3361.
  • “Divergent synthesis of kinase inhibitor derivatives, leading to discovery of selective Gck inhibitors” Bio. Med. Chem. Lett. 2017, 27, 2144-2147.
  • “Insulinotropic and anti-apoptotic effects of nobiletin in INS-1D β-cells” J. Funct. Foods 2017 30, 8–15.
  • “Synthesis of chemical-biology tools enabling in vivo imaging and analysis of epigallocatechin gallate.” Heterocycles 2016, 93, 218–242.
  • “Stereospecific Construction of 2-Vinyl 3-Hydroxybenzopyrane Rings: Total Synthesis of Teadenol A and B” Org. Biomol. Chem. 2016, 14, 10783–10786.
  • “Concise Synthesis of Anserine: Efficient Solvent Tuning in Asymmetric Hydrogenation Reaction” Synlett 2016, 27, 2734–2736.
  • “Practical synthesis of spermine, thermospermine and norspermine” Chem. Pharm. Bull. 2016, 64, 1403–1407.
  • “Practical Total Syntheses of Acromelic Acids A and B” Chem. Pharm. Bull. 2016, 64, 723–732.
  • “Synthesis of food effective constituents toward the development for chemical biology investigations” J. Syn. Org. Chem., Jpn. 2016, 74, 412–425.
  • “SYNTHESES OF METHYLATED CATECHINS AND THEAFLAVINS USING 2-NITROBENZENESULFONYL GROUP TO PROTECT AND DEACTIVATE PHENOL” J. Antibiot. 2016, 69, 299–312.
  • “Applications of C–H Insertion Reaction in Total Synthesis of Biologically Active Heterocyclic Natural Products” Kan, T.; Asakawa, T.; Inai, M. Heterocycles 2016, 92, 31–43.
  • “Ecteinascidins. A Review of the Chemistry, Biology and Clinical Utility of Potent Tetrahydroisoquinoline Antitumor Antibiotics” Nat. Prod. Rep. 2015, 32, 328–347.
  • “Stereocontrolled Total Syntheses of Optical Active Furofuran Lignans” Synthesis 2015, 47, 3513–3521.
  • “Isolation and total syntheses of cytotoxic cryptolactone A1, A2, B1 and B2: α,β-unsaturated δ-lactones from the aphid Cryptomyzus sp.” J. Nat. Prod. 2014, 77, 2459−2464.
  • “Total Syntheses of (+)-Sesamin and (+)-Sesaminol” Chem. Lett. 2014, 43, 1572–1574. [Editor’s choice and open access article]
  • “Practical synthesis of natural plant-growth regulator 2-azahypoxanthine, its derivatives, and biotin-labeled probes” Org. Biomol. Chem. 2014, 12, 3813–3815.
  • “Stereocontrolled total synthesis of Hedyotol A” Org. Lett. 2014, 16, 1980–1983.
  • “Practical Total Synthesis of Acromelic acid A and B” T. Org. Lett. 2014, 16, 1976–1979.
  • “Total Synthesis of (–)-SB-203207” Org. Lett. 2014, 16, 1646–1649.
  • “Practical Synthesis of Kainoids: A New Chemical Prove Precursor and a Fluorescent Probe” Org. Lett. 2014, 16, 564−567.
  • “Synthetic study of Flavonoid and its Chemical Probes” Heterocycles 2014, 88, 1371–1396.
  • “A Method to Prepare Optically Active Acyclic alpha-Benzylketones by Thermodynamically Controlled Deracemization” Eur. J. Org. Chem. 2013, 8208–8213.
  • “Stereocontrolled total synthesis of sphingofungin E” Eur. J. Org. Chem. 2013, 6789–6792.
  • “Chemoselective Hydrogenation Reaction of Unsaturated Bonds in the Presence of o-Nitrobenzenesulfonyl Group” Org. Lett. 2013, 15, 1306–1309.
  • “Xanthouroleuconaphin: a yellowish pigment from the aphid Uroleucon nigrotuberculatum and its total synthesis” Tetrahedron 2013, 69, 1808–1814.
  • “Synthesis of Theaflavins via Biomimetic Oxidative Coupling Reaction” Synlett 2013, 24, 479–482.
  • “Catalytic Desymmetrization of Cyclohexadienes by Asymmetric Bromolactonizatio” Org. Lett. 2012, 14, 6016–6019.
  • “A Total Synthesis of Yellowish Aphid Pigment Furanaphin through Fries Rearrangement Assisted by Boron Trifluoride-Acetic Acid Complex” Synlett 2012, 23, 1789–1792.
  • “Construction of an Asymmetric Quaternary Carbon by Asymmetric Aza-Claisen Rearrangement and its Application to a Total Synthesis of (+)-alpha-Cuparenone” Tetrahedron: Asymmetry 2012, 23, 739–741.
  • “Megouraphin Glucoside: Two Yellowish Pigments from the Aphid Megoura crassicauda Mordvilko” Heterocycles 2012, 85, 95–101.
  • “Promotion of Asymmetric Aza-Claisen Rearrangement of N-Allylic Carboxamides Using Excess Base” Synlett 2011, 2967–2970.
  • “Viridaphin A1 Glucoside, a Green Pigment Possessing Cytotoxicity and Antibacterial Activity from the Aphid Megoura crassicauda Mordvilko” J. Nat. Prod. 2011, 74, 1812–1816.
  • “Total Synthesis of (+)-Brefeldin C utilizing aza-Claisen Rearrangement” Synlett 2011, 1459–1461.
  • “Total Synthesis of (+)-Antimycin A Family” Eur. J. Org. Chem. 2011, 2719–2729.
  • “PET Imaging Investigation of Nobiletin Based on a Practical Total Synthesis” Chem. Commun. 2011, 47, 2868–2870.
  • “Synthetic Studies on Palau’amine Construction of the Cyclopentane Core via an Asymmetric 1,3-Dipolar Cycloaddition” Tetrahedron Lett. 2010, 51, 6557–6559.
  • “A facile and practical method of preparing optically active α-monosubstituted cycloalkanones by thermodynamically controlled deracemization” Tetrahedron 2010, 66, 9450–9455.
  • “Solid Support Synthesis of Artificial Phospholipids” Synlett 2009, 3373–3374.
  • “Concise Synthesis of Chafurosides A and B” Org. Lett. 2009, 11, 2233–2236.
  • “Identification and characterization of flavonoids as sialyltransferase inhibitors” Biochem. Biophys. Res. Commun. 2009, 609–613.
  • “Stereocontrolled total synthesis of (–)-myriocin” Tetrahedron: Asymmetry 2008, 19, 2771–2773.
  • “A Practical Total Synthesis of (+)-Antimycin A9” J. Antibiot. 2007, 60, 65–72.

教育・研究に対する考え方

研究を進める上では、刻々と変わる状況を常に客観的に見極める観察力,粘り強く問題に立ち向かいそれを解決する実行力が必要です。天然物合成は、学生の知識,行動力を養うために最適の研究分野の一つであると考えており、これらを基盤として優秀な薬剤師,研究者の輩出に貢献したいと考えています。

研究シーズ集に関するキーワード

天然物全合成,アルカロイド,ポリフェノール,カテキン,ケミカルプローブ

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