伊藤 邦彦(ITOH Kunihiko)
薬学部薬学科(臨床薬効解析学分野) 教授
薬学研究院(臨床薬効解析学教室) 教授(兼務)


1984年3月 東北大学薬学部卒業
1989年3月 東北大学大学院薬学研究科博士課程修了








  • ファージディスプレイ法によるヒト型抗体の開発と臨床応用
  • 抗体エピトープペプチドワクチンの開発と臨床応用
  • tRNAフラグメントのバイオマーカー応用研究




1990年4月 日本学術振興会特別研究員PD
1992年4月 東北大学医学部付属病院助手
1993年9月 Scripps Research Institute, Research Associate
1995年11月 秋田大学医学部助教授
2005年4月 静岡県立大学薬学部教授




  • Immuno-Northern Blotting: Detection of RNA Modifications by Using Antibodies against Modified Nucleosides. PLoS ONE, 10, e0143756 (2015)
  • Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy. Seizure, 33, 76-80 (2015)
  • Plasma vitamin K concentrations depend on CYP4F2 polymorphism and influence on anticoagulation in Japanese patients with warfarin therapy. Thromb. Res., 135, 861–866 (2015)
  • Reduced folate carrier 1 gene expression levels are correlated with methotrexate efficacy in Japanese patients with rheumatoid arthritis. Drug Metab. Pharmacokinrt., 30, 227–230 (2015)
  • Influence of uridine diphosphate glucuronosyltransferase (UGT) 2B7 -161C>T polymorphism on the concentration of valproic acid in pediatric epilepsy patients. Ther. Drug Monit., 36, 406–409 (2014)
  • Simultaneous microdetermination of bosentan, ambrisentan, sildenafil, and tadalafil in plasma using liquid chromatography/tandem mass spectrometry for pediatric patients with pulmonary arterial hypertension. J. Pharm. Biomed. Anal., 89, 227–232 (2014)
  • Bladder endothelin-1 receptor binding of bosentan and ambrisentan. J. Pharmacol. Sci., 124, 86–91 (2014)
  • Endothelin-1 Receptors in Rat Tissues: Characterization by Bosentan, Ambrisentan and CI-1020. Biol. Pharm. Bull., 37, 461–465 (2014)
  • 4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy. Epilepsy Research, 108, 1046–1051 (2014)
  • Identification of anti-CD98 antibody mimotopes for inducing antibodies with antitumor activity by mimotope immunization. Cancer Sci., 105, 396–401 (2014)
  • Conformational Change in Transfer RNA Is an Early Indicator of Acute Cellular Damage. J Am Soc Nephrol., 25, 2316–2326 (2014)
  • Relationship between ABCB1 gene polymorphisms and severe neutropenia in patients with breast cancer treated with doxorubicin/cyclophosphamide chemotherapy. Drug Metab Pharmacokinet, 30, 149–153 (2014)
  • Influence of uridine diphosphate glucuronosyltransferase (UGT) 2B7 -161C>T polymorphism on the concentration of valproic acid in pediatric epilepsy patients. Ther. Drug Monit., 36, 406–409 (2014)
  • Retrospective Analysis of Severe Neutropenia in Patients Receiving Concomitant Administration of Docetaxel and Clarithromycin. Chemotherapy, 59, 407–413 (2013)
  • Characterization of the carrier-mediated transport of ketoprofen, a nonsteroidal anti-inflammatory drug, in rabbit corneal epithelium cells. J. Pharm. Pharmacol., 65, 171–180 (2013)
  • Influence of CYP4F2 polymorphisms and plasma vitamin K levels on warfarin sensitivity in Japanese pediatric patients. Drug Metab. Pharmacokinet., 28, 132–137 (2013)
  • A single nucleotide polymorphism of reduced folate carrier 1 predicts methotrexate efficacy in Japanese patients with rheumatoid arthritis. Drug Metab. Pharmacokinet., 28, 164–168 (2013)
  • Polymorphisms of the UDP-Glucuronosyl Transferase 1A Genes Are Associated with Adverse Events in Cancer Patients Receiving Irinotecan-Based Chemotherapy. Tohoku J. Exp. Med., 229, 107–114 (2013)
  • Association of ABCB1 polymorphisms with the antiemetic efficacy of granisetron plus dexamethasone in breast cancer patients. Drug Metab. Pharmacokinet.,28, 299–304 (2013)
  • Risk factors for hyperammonemia in pediatric epilepsy patients. Epilepsia, 54, 983–989 (2013)
  • Risk factors for hyperammonemia associated with valproic acid therapy in adult epilepsy patients.. Epilepsy Res., 101, 202–209 (2012)
  • An artifact derived from pseudogene led to the discovery of microRNA binding site polymorphism in 3′-untranslated region of human dihydrofolate reductase gene. Drug Metab. Pharmacokinet. Drug Metab. Pharmacokinet., 27, 263–267 (2012)
  • Genotype distributions and allele frequencies of possible major depressive disorder-associated SNPs, CREB1 rs4675690 and Piccolo rs2522833 in a Japanese population. Biol. Pharm. Bull., 35, 265-8 (2012)
  • Concise synthesis of catechin probes enabling analysis and imaging of EGCg. Chem. Commun., 47, 1794-6 (2011)
  • Generation of Fab Fragment-like Molecular Recognition Proteins against Staphylococcal Enterotoxin B by Phage Display Technology. Clin. Vaccine Immunol., 17, 1708-17 (2010)
  • Generation of AcGFP-labeled single-chain Fv against 5-methyl 2'-deoxycytidine from a hyperimmunized mouse using phage display technology. Protein Eng Des Sel., 23, 881-8 (2010)
  • Dihydrofolate reductase gene intronic 19-bp deletion polymorphisms in a Japanese population. Drug Metab. Pharmacokinet., 25, 516-8 (2010)
  • Generation of a recombinant single-chain variable fragment (scFv) targeting 5-methyl-2'-deoxcytidine. J. Biochem. 147, 135-141(2010)
  • Antibody epitope peptides as potential inducers of IgG antibodies against CD98 oncoprotein. Cancer Sci., 100, 126-131 (2009)
  • Effect of VKORC1-1639G>A polymorphism, body weight, age, and serum albumin alterations on warfarin response in Japanese patients. Thromb. Res., 124, 161-166 (2009)
  • Plasma total homocysteine level and methylenetetrahydrofolate reductase 677CT genetic polymorphism in Japanese patients with rheumatoid arthritis. Biomarkers, 14, 49-54 (2009)
  • Genetic polymorphisms in folate pathway enzymes as a possible marker for predicting the outcome of methotrexate therapy in Japanese patients with rheumatoid arthritis., J. Clin. Pharm. Ther., 34, 355-361 (2009)
  • Application of fluorescence polarization immunoassay for determination of methotrexate-polyglutamates in rheumatoid arthritis patients. Tohoku J. Exp. Med., 215, 95-101 (2008)
  • Influence of the tyrosine hydroxylase val81met polymorphism and catechol-O-methyltransferase val58met polymorphism on the antidepressant effect of milnacipran. Human Psychopharmacology: Clinical and Experimental, 23, 121-128 (2008)
  • Identification of cell proliferation-associated epitope on CD98 oncoprotein using phage display random peptide library. Cancer Sci., 98, 1696-1700 (2007)
  • Cloning and expression of two human recombinant monoclonal Fab fragments specific for EBV viral capsid antigen. Int. Immunol., 19, 331-336 (2007)
  • Genetic polymorphism of C452T (T127I) in human γ-glutamyl hydrolase in a Japanese population. Biol. Pharm. Bull. , 30, 839-841 (2007)
  • No association of the G1287A polymorphism in the norepinephrine transporter gene and susceptibility to major depressive disorder in a Japanese population., Biol. Pharm. Bull., 30, 1996-1998 (2007)
  • ゲムシタビン施行切除不能膵がん患者における予後因子の検討. 医療薬学, 40, 734–741 (2014)
  • エタネルセプト25mg皮下注シリンジ週2回投与から50mg皮下注シリンジ週1回投与に変更した患者における有用性の評価. 医療薬学, 38, 723–728(2012)
  • 臨床薬学演習のコンテンツ作成における大学連携のメリット(総説) 薬学雑誌, 132, 31-4 (2012)
  • 薬効モニタリングの実践9 -胃・十二指腸潰瘍、13-排尿障害、16-関節リウマチ 薬局, 62, 85-9, 108-12, 126-31 (2011)
  • 適切な支持療法薬の選択により患者のQOLを高める. 薬局, 61, 57-66 (2010)
  • ワルファリン服用患者における出血リスクに対するプロトンポンプ阻害薬併用の影響. 日本病院薬剤師会雑誌, 46, 535-8 (2010)
  • WarfarinとビタミンKの相互作用に関する文献的研究. 臨床薬理, 41, 43-51 (2010)
  • 抗体医薬の新展開 がん治療薬としてのミモトープペプチドワクチン ファルマシア, 44, 523-527 (2008)
  • ファージディスプレイによる診断治療に有用なヒト型抗体医薬の開発(総説) 薬学雑誌, 127, 43-53 (2007)