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静岡県立大学教員データベース


教員情報詳細


写真:菅野 裕一朗

氏名
菅野 裕一朗(KANNO Yuichiro)
所属・職名
薬学部薬学科(衛生分子毒性学分野) 講師
薬学研究院(衛生分子毒性学教室) 講師(兼務)
部屋番号
薬学部棟6311号室
Eメールアドレス
ykanno@u-shizuoka-ken.ac.jp
ホームページアドレス(URL)
https://w3pharm.u-shizuoka-ken.ac.jp/eisei/

学歴

2002年3月 東邦大学薬学部衛生薬学科卒業
2004年3月 東邦大学大学院薬学研究科博士前期課程修了
2007年3月 東邦大学大学院薬学研究科博士後期課程修了

学位

博士(薬学)(東邦大学・2007年)

専門分野

衛生化学・分子毒性学・薬物代謝学

担当科目

 

主要研究テーマ

  • 異物受容体の活性化機構の解明
  • 選択的核内受容体調節薬による核内受容体活性調節機構の解明
  • 芳香族炭化水素受容体(AhR)の生理的役割の解明

所属学会

日本薬学会
日本癌学会
American Society for Pharmacology and Experimental Therapeutics (ASPET )
日本生化学会
日本分子生物学会
日本毒性学会
日本薬物動態学会

主な経歴

2007年4月 東邦大学薬学部 講師
2020年5月 静岡県立大学薬学部 講師

受賞歴

2007年 日本薬学会環境・衛生部会賞受賞

主な社会活動

 

主要研究業績

  • Kanno, Y.; Kusakabe, T.; Saito, N.; Kikkawa, S.; Takahashi, K.; Azumaya, I.; Nemoto, K.; Kato, K. Improved Synthesis and Determination of the Biologically Active Diastereomer of YK11. Molbank 2020, M1125, 2020.
  • Yamashita N, Kanno Y*, Saito N, Terai K, Sanada N, Kizu R, Hiruta N, Park Y, Bujo H, Nemoto K. Aryl hydrocarbon receptor counteracts pharmacological efficacy of doxorubicin via enhanced AKR1C3 expression in triple negative breast cancer cells. Biochem Biophys Res Commun. 516 693-698 2019
  • Saito N, Kawase K, Yamashita N, Tang Y, Wang Y, Wang J, Liu Y, Li N, Li W, Cheng MS, Koike K, Kanno Y*, Nemoto K. Identification of 10-dehydrooxyglycyuralin E as a selective human estrogen receptor alpha partial agonist. Bioorg Chem. 88 102977 2019
  • Kanno Y*, Shuai Zhao, Naoya Yamashita, Nao Saito, Aoi Ujiie, Rie Iijima, Nami Kikawa, Kiyomitsu Nemoto and Yoshio Inouye, Cell cycle and apoptosis regulator 1, CCAR1, regulates enhancer-dependent nuclear receptor CAR transactivation Mol. Pharmacol. 95 120-126 2019
  • Yamashita N, Saito N, Zhao S, Terai K, Hiruta N, Park Y, Bujo H, Nemoto K, Kanno Y*.  Heregulin-induced cell migration is promoted by aryl hydrocarbon receptor in HER2-overexpressing breast cancer cells.  Exp Cell Res. 366 34-40 2018
  • Yatsu T, Kusakabe T, Kato K, Inouye Y, Nemoto K, Kanno Y*.  Selective Androgen Receptor Modulator, YK11, Up-Regulates Osteoblastic Proliferation and Differentiation in MC3T3-E1 Cells.  Biol Pharm Bull. 41 394-398 2018 
  • Kanno Y*, Kure Y, Kobayashi S, Mizuno M, Tsuchiya Y, Yamashita N, Nemoto K and Inouye Y.  The tripartite motif containing 24 acts as a novel coactivator of the constitutive active/androstane receptor.  Drug Metab Dispos. 46 46-52. 2018
  • Kanno Y*, Yatsu T, Yamashita N, Zhao S, Li W, Imai M, Kashima M, Inouye Y, Nemoto K, Koike K. Alisol B 23-acetate from the rhizomes of Alisma orientale is a natural agonist of the human pregnane X receptor. Phytomedicine. 26 22-27. 2017
  • Yamashita N, Kondo M, Zhao S, Li W, Koike K, Nemoto K, Kanno Y*. Picrasidine G decreases viability of MDA-MB 468 EGFR-overexpressing triple-negative breast cancer cells through inhibition of EGFR/STAT3 signaling pathway. Bioorg Med Chem Lett. 27 2608-2612 2017
  • Zhao S, Kanno Y*, Li W, Sasaki T, Zhang X, Wang J, Cheng M, Koike K, Nemoto K, Li H. Identification of Picrasidine C as a Subtype-Selective PPARα Agonist. J Nat Prod. 79 3127-3133 2016
  • Shen R, Kusakabe T, Yatsu T, Kanno Y, Takahashi K, Nemoto K, Kato K. Palladium(II) Catalyzed Cyclization-Carbonylation-Cyclization Coupling Reaction of (ortho-Alkynyl Phenyl) (Methoxymethyl) Sulfides Using Molecular Oxygen as the Terminal Oxidant. Molecules. 21. E1177 2016
  • Kanno Y*, Tanuma N, Yazawa S, Zhao S, Inaba M, Nakamura S, Nemoto K, Inouye Y. Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR. Drug Metab Dispos. 44 1158-1163. 2016
  • Zhao S, Kanno Y*, Li W, Wakatabi H, Sasaki T, Koike K, Nemoto K, Li H. Picrasidine N Is a Subtype-Selective PPARβ/δ Agonist. J Nat Prod. 79 879-885. 2016
  • Kuang X, Li W, Kanno Y, Yamashita N, Kikkawa S, Azumaya I, Nemoto K, Asada Y, Koike K. Euphorins A-H: bioactive diterpenoids from Euphorbia fischeriana. J Nat Med. 70 12-22. 2016
  • Kuang X, Li W, Kanno Y, Yamashita N, Nemoto K, Asada Y, Koike K. ent-Atisane diterpenoids from Euphorbia fischeriana inhibit mammosphere formation in MCF-7 cells. J Nat Med. 70 120-126 2016
  • Kanno Y*, Zhao S, Yamashita N, Yanai K , Nemoto K , Inouye Y. Androgen receptor functions as a negatively transcriptional regulator of DEPTOR, mTOR inhibitor. J Toxicol Sci. 40 753-758. 2015
  • Kanno Y*, Inajima J, Kato S, Matsumoto M, Tokumoto C, Kure Y, Inouye Y. Protein arginine methyltransferase 5 (PRMT5) is a novel coactivator of constitutive androstane receptor (CAR). Biochem Biophys Res Commun. 459 143-147. 2015
  • Hosoda, K., Kanno, Y., Sato, M., Inajima, J., Inouye, Y., Yanai, K.. Identification of CAR/RXRα Hetero-dimer Binding Sites in the Human Genome by a Modified Yeast One-Hybrid Assay. Advances in Biological Chemistry, 5 83. 2015
  • Kanno Y*, Tanuma N, Yatsu T, Li W, Koike K, Inouye Y. Nigramide J is a novel potent inverse agonist of the human constitutive androstane receptor. Pharmacol Res Perspect. 2 2. 2014
  • Kuang X, Li W, Kanno Y, Mochizuki M, Inouye Y, Koike K. Cycloartane-type triterpenes from Euphorbia fischeriana stimulate human CYP3A4 promoter activity. Bioorg Med Chem Lett. 24 5423-5427. 2014
  • Dhage YD, Daimon H, Peng C, Kusakabe T, Takahashi K, Kanno Y, Inouye Y, Kato K. Pd(II)-catalyzed ligand controlled synthesis of pyrazole-4-carboxylates and benzo[b]thiophene-3-carboxylates. Org Biomol Chem. 12 8619-8626 2014
  • Kanno Y*, Yatsu T, Li W, Koike K, Inouye Y. Nigramide C is a natural agonist of human pregnane x receptor. Drug Metab Dispos. 42 1084-1089. 2014
  • Kanno Y*, Ota R, Someya K, Kusakabe T, Kato K, Inouye Y. Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression. Biol Pharm Bull. 36 1460-1465. 2013
  • Kanno Y*, Tanuma N, Takahashi A, Inouye Y. TO901317, a potent LXR agonist, is an inverse agonist of CAR. J Toxicol Sci. 38 309-315. 2013
  • Guo H, Zhao H, Kanno Y, Li W, Mu Y, Kuang X, Inouye Y, Koike K, Jiang H, Bai H. A dihydrochalcone and several homoisoflavonoids from Polygonatum odoratum are activators of adenosine monophosphate activated protein kinase. Bioorg Med Chem Lett. 23 3137-3139. 2013
  • Zhao S, Ohara S, Kanno Y*, Midorikawa Y, Nakayama M, Makimura M, Park Y, Inouye Y. HER2 overexpression-mediated inflammatory signaling enhances mammosphere formation through up-regulation of aryl hydrocarbon receptor transcription. Cancer Lett. 330 41-48. 2013
  • Kanno Y*, Serikawa T, Inajima J, Inouye Y. DP97, a DEAD box DNA/RNA helicase, is a target gene-selective co-regulator of the constitutive androstane receptor. Biochem Biophys Res Commun. 426 38-42. 2012
  • Zhao S, Kanno Y*, Nakayama M, Makimura M, Ohara S, Inouye Y. Activation of the aryl hydrocarbon receptor represses mammosphere formation in MCF-7 cells. Cancer Lett. 317 192-198. 2012
  • Kanno Y*, Hikosaka R, Zhang SY, Inoue Y, Nakahama T, Kato K, Yamaguchi A, Tominaga N, Kohra S, Arizono K, Inouye Y.(17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21- carboxylic acid methyl ester (YK11) is a partial agonist of the androgen receptor. Biol Pharm Bull. 34 318-323. 2011
  • Kanno Y, Inouye Y. [Mechanism for subcellular localization of nuclear receptor CAR]. Yakugaku Zasshi. 131(3):359-65. Review. Japanese. 2011
  • Kanno Y*, Inoue Y, Inouye Y. 5-aminoimidazole-4-carboxamide-1-beta-ribofuranoside (AICAR) prevents nuclear translocation of constitutive androstane receptor by AMP-activated protein kinase (AMPK) independent manner. J Toxicol Sci. 35 571-576. 2010
  • Kanno Y*, Inouye Y. A consecutive three alanine residue insertion mutant of human CAR: a novel CAR ligand screening system in HepG2 cells. J Toxicol Sci. 35 515-525. 2010
  • Kanno Y*, Miyazaki Y, Inouye Y. The nuclear import of the constitutive androstane receptor by importin/Ran-GTP systems. Biochim Biophys Acta Mol Cell Res 1803 968-974. 2010
  • Kanno Y*, Miyama Y, Ando M, Inouye Y. Dependence on the microtubule network and 90-kDa heat shock protein of phenobarbital-induced nuclear translocation of the rat constitutive androstane receptor. Mol Pharmacol. 77 311-316. 2010
  • Kanno Y*, Takane Y, Takizawa Y, Inouye Y. Suppressive effect of arylhydrocarbon receptor repressor on transcriptional activity of estrogen receptor alpha by protein-protein interaction in stably and transiently expressing cell lines. Mol Cell Endocrinol. 291 87-94. 2008
  • Kanno Y*, Miyama Y, Takane Y, Nakahama T, Inouye Y. Identification of intracellular localization signals and of mechanisms underlining the nucleocytoplasmic shuttling of human aryl hydrocarbon receptor repressor. Biochem Biophys Res Commun. 364 1026-1031. 2007
  • Kanno Y, Suzuki M, Miyazaki Y, Matsuzaki M, Nakahama T, Kurose K, Sawada J, Inouye Y. Difference in nucleocytoplasmic shuttling sequences of rat and human constitutive active/androstane receptor. Biochim Biophys Acta Mol Cell Res 1773 934-944. 2007
  • Kanno Y, Takane Y, Izawa T, Nakahama T, Inouye Y. The inhibitory effect of aryl hydrocarbon receptor repressor (AhRR) on the growth of human breast cancer MCF-7 cells. Biol Pharm Bull. 29 1254-1257. 2006
  • Nishihashi H, Kanno Y, Tomuro K, Nakahama T, Inouye Y. Primary structure and organ-specific expression of the rat aryl hydrocarbon receptor repressor gene. Biol Pharm Bull. 29 640-647. 2006
  • Kanno Y, Aoki S, Mochizuki M, Mori E, Nakahama T, Inouye Y. Expression of constitutive androstane receptor splice variants in rat liver and lung and their functional properties. Biol Pharm Bull. 28 2058-2062. 2005
  • Kanno Y, Suzuki M, Nakahama T, Inouye Y. Characterization of nuclear localization signals and cytoplasmic retention region in the nuclear receptor CAR. Biochim Biophys Acta Mol Cell Res 1745 215-222. 2005
  • Kanno Y, Otsuka S, Hiromasa T, Nakahama T, Inouye Y. Diurnal difference in CAR mRNA expression. Nucl Recept. 2 6. 2004
  • Kanno Y, Moriyama T, Ichikawa H, Mizuno M, Nakahama T, Inouye Y, Transcriptional Determination of Sexually Dimorphic Expression of Nuclear Receptor Constitutively Active Receptor (CAR) in Wistar Rats. Journal of Health Science. 50 384. 2004
  • Kanno Y, Aoki S, Nakahama T, Inouye Y., Role of the Defective Splicing of mRNA in the Lack of Pulmonary Expression of Constitutively Active Receptor in Rat Journal of Health Science, 49 541-546 2003
  • Nito N, Kanno Y, Muto A, Uesugi A, Nakahama T, Inouye Y, Biological Evaluation of the Pollution of the Tsurumi River with 7-Ethoxycoumarin O-Deethylase Activity Induced by River Sediment Extracts in HepG2 Cells, Journal of Health Science, 49 8-12, 2003

教育・研究に対する考え方

教育:学問を学ぶ意味と楽しさを感じてもらいたい。そしてその学問を社会で利用できる人材を育てるような教育をしたいと考えています。
研究:様々な学問から成り立っているのが「衛生化学」という学問です。その基盤となる学問を作っていくような研究をしていきたいと考えています。

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