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静岡県立大学教員データベース


教員情報詳細


氏名
井上 健一郎(INOUE Ken-ichiro)
所属・職名
看護学部看護学科 教授
看護学研究科 教授(兼務)
健康支援センター 副センター長
電話番号
054-264-5460
部屋番号
看護学部棟(草薙キャンパス)13210号室
Eメールアドレス
inoue-k(ここに@を入れてください)u-shizuoka-ken.ac.jp

学歴

1995年3月 山梨医科大学医学部卒業
2001年3月 京都府立医科大学医学研究科中途退学


学位

医学博士


専門分野

環境免疫毒性学、呼吸器病学、アレルギー学


担当科目

症候論、基礎健康科学実習、基礎セミナー、臨床検査・画像診断、看護統合セミナー


主要研究テーマ

環境ストレスが呼吸器・アレルギー応答等に及ぼす影響


所属学会

日本内科学会
日本呼吸器学会
日本衛生学会
日本アレルギー学会
日本エンドトキシン・自然免疫研究会


主な経歴

2007年4月 国立環境研究所生体影響評価研究室 室長
2010年4月 北里大学 教授
2012年3月 国際医療福祉大学 教授
2015年4月 静岡県立大学看護学部 教授


主な社会活動

日本 Shock 学会評議員
日本エンドトキシン・自然免疫研究会理事
日本衛生学会編集委員
Editor in Chief
・Journal of Clinical Toxicology
・Journal of Environmental & Analytical Toxicology
・Biomedical Research (Asia-Pacific region)
Editorial Board Member
・Recent Patents of Anti-Cancer Drug Discovery
・The Open Lung Cancer Journal
・Journal of Bioscience and Medicine
・Air & Water Borne Disease
・Medicine Advancement in Genetic Engineering
・Journal of Environmental & Analytical Toxicology
・World Journal of Respirology
・Journal Allergy and Clinical Immunology Research
・Journal of Contemporary Immunology
・International Archives of Allergy and Immunology
・JSM Clinical Pharmaceutics
・The Journal of Allergy Disorders and Therapy
・Clinical Journal of Allergy and Immunology
・Nano-medicine & Nano-biotechnology


主要研究業績

2011年以降

【2011】
・Kamata H, Tasaka S, Inoue K, Miyamoto K, Nakano Y, Shinoda H, Kimizuka Y, Fujiwara H, Ishii M, Hasegawa N, Takamiya R, Fujishima S, Takano H, Ishizaka A: Carbon black nanoparticles enhance bleomycin-induced lung inflammatory and fibrotic changes in mice. Exp Biol Med 236: 315-324, 2011
・Inoue K, Yanagisawa R, Koike E, Nakamura R, Ichinose T, Tasaka S, Kiyono M, Takano H: Effects of carbon black nanoparticles on elastase-induced emphysematous lung injury in mice. Basic Clin Pharmacol Toxicol 108: 234-240, 2011
・Inoue K, Fujitani Y, Kiyono M, Hirano S, Takano H: In vitro effects of nanoparticle-rich diesel exhaust particles on splenic mononuclear cells. Immunopharmacol Immunotoxicol 33: 519-524, 2011
・Inoue K, Takano H: Particulate matter-induced health effects: who is susceptible? Environ Health Perspect 119: 2011
・Nakamura R, Inoue K, Fujitani Y, Kiyono M, Hirano S and Takano H: In vitro study of the effects of nanoparticle-rich diesel exhaust particles on IL-18 production in splenocytes. J Toxicol Sci 36: 823-827, 2011

【2012】
・Ito T, Inoue K, Nishimura N, Takano H: Phthalate esters modulate the differentiation and maturation of mouse peripheral blood mononuclear cell-derived dendritic cells. J Appl Toxicol. 32: 142-148, 2012
・Kiyono M, Sone Y, Miyahara K, Oka Y, Nakamura M, Nakamura R, Sato MH, Pan-Hou H, Sakabe K, Inoue K: Genetic expression of bacterial MerC fused plant SNARE in Saccharomyces cerevisiae increased mercury accumulation. Biochem Eng J 56: 137-141 2012
・Kiyono M, Oka Y, Sone Y, Tanaka M, Nakamura R, Sato M, Pan-Hou H, Sakabe K, Inoue K: Expression of the bacteria heavy metal transporter Merc fused with a plant SNARE, SYP121, in Arabidosis thaliana increases cadmium accumulation and tolerance. Planta Madica 235: 841-850, 2012
・Nakamura R, Inoue K, Fujitani Y, Kiyono M, Hirano S, Takano H: Effects of nanoparticles on IL-17 production in vitro. J Immunotoxicol 9: 72-76, 2012
・He M, Ichinose T, Yoshida S, Yamamoto S, Inoue K, Takano H, Yanagisawa R, Nishikawa M, Mori I, Sun G, ShibamotoT: Asian sand dust enhances murine lung inflammation caused by Klebsiella pneumonia. Toxicol Appl Pharmacol 258: 237-247, 2012
・Yasuda A, Inoue K, Sanbonngi C, Yanagisawa R, Ichinose T, Tanaka M, Yoshikawa T, Takano H: Dietary supplementation with fructtooligosaccharides attenuates allergic peritonitis in mice. Biochem Biophys Res Commun. 422:546-550, 2012
・Yanagisawa R, Warabi E, Inoue KI, Yanagawa T, Koike E, Ichinose T, Takano H, Ishii T: Peroxiredoxin I null mice exhibits reduced acute lung inflammation following ozone exprosure. J Biochem 152: 595-601, 2012
・Iwasaki T, Yamamoto T, Inoue K, Takaku K : A Case of Lemierr’s Syndrome in association with Liver abscess without any other metastatic lesions. Intern Med 51: 1419-1423, 2012

【2013】
・Naota M, Mukaiyama T, Shimada A, Shiotu,S, Kohara Y, Morita T, Inoue K, Takano H: Pathological study of chronic pulmonary toxicity induced by intratracheally instilled Asian sand dust (Kosa). Toxicol Pathol 41: 48-62, 2013
・Tanaka M, Inoue K, Momoi T, Takano H: In vivo immunoamplifying effects of di-(2-ethylexyl) phthalate on cytokine response. Immunopharmacol Immunotoxicol. 35: 147-150, 2013
・Tanaka M, Aoki Y, Takano H, Fujitani Y, Hirano S, Nakamura R, Sone Y, Kiyono M, Ichinose T, Itoh T, Inoue K: Effects of exposure to nanoparticles-rich or depleted exhaust on allergic pathophysiology in the murine lung. J Toxicol Sci. 38: 35-48, 2013
・Naota M, Shimada A, Morita T, Yamamoto Y, Inoue K, Takano H: Cavwolae-mediated endocytosis of intratracheally instilled gold colloid nanoparticles at the air-blood barrier in mice. Toxicol Pathol 41: 487-96, 2013
・He M, Inoue K, Yoshida S, Tanaka M, Takano H, Sun G, Ichinose T.Effects of airway exposure to di-(2-ethylhexyl) phthalate on allergic rhinitis. Immunopharmacol Immunotoxicol 35: 390-5, 2013
・Sadakane K, Ichinose T, Takano H, Yanagisawa R, Inoue KI, Kawazato H, Yasuda A, Hayakawa K: Organic Chemicals in Diesel Exhaust Particles Enhance Picryl Chloride-Induced Atopic Dermatitis in NC/Nga Mice. Int Arch Allergy Immunol 162: 7-15, 2013
・Tanaka M, Takano H, Fujitani Y, Hirono S, Ichinose T, Shimada A, Inoue K: Effects of exposure to nanoparticles-rich diesel exhaust on 8-OHdG synthesis in the mouse asthmatic lung. Exp Ther Med 6: 703-706, 2013
・Inoue K, Takano H. Gabapentin for refractory chronic cough. Lancet 381: 35, 2013
・Inoue K, Takano H. Sepsis definitions. Lancet 381: 2249-2250, 2013

【2014】
・Rattanapinyopituk K, Shimada A, Morita T, Togawa M, Hasegawa T, Seko Y, Inoue K, Takano H: Ultrastructural changes in the air-blood barrier in mice after intratracheal instillation of Asian sand dust and gold nanoparticles. Exp Toxicol Pathol 76: 377-387, 2014
・Sadakane K, Ichinose T, Takano H, Yanagisawa R, Koike E, Inoue KI: The alkylphenols 4-nonylphenol, 4-tert-octylphenol and 4-tert-butylphenol aggravate atopic dermatitis-like skin lesions in NC/Nga mice. J Appl Toxicol 34: 893-902, 2014
・Tanaka M, Inoue K, Kitamura Y, Shimada A, Takano H. In vitro action of Sho-seiryu-to on allergen exposed mononuclear cells. Int J Immunopathol Pharmacol 27, 515-518, 2014
・Inoue K, Tanaka M, Takano H. DEP-induced T(H)17 response in asthmatic subjecs. J Allergy Clin Immunol. 133: 1495-1496. 2014
・Rattanapinyopituk K, Shimada A, Morita T, Sakurai M, Asano A, Hasegawa T, Inoue K, Takano H. Demonstration of the clathrin-and caveolin-mediated endcytosisi at the maternal-fetal barrier in mouse placenta after intravenous administration of gold nanoparticled. J Vet Med Sci. 76:377-87. 2014
・Tanaka M, Inoue K, Takano H: Progress in the study concerning adverse effects of particulate matters on allergy. Jpn J Allergol 63: 1289-1297, 2014
・Honda A, Koike E, Yanagimota R, Inoue K, Takano H: Development of the studies on environmental chemicals and allergy. Jpn J Allergol 63: 1205-1214, 2014

【2015】
・Shimada A, Kohara Y, Naota M, Kobayashi Y, Morita T, Inoue K, Takano H. Pathological study of chronic pulmonary toxicity induced by intratracheally instilled Asian sand dust (Kosa): possible association of fibrosis with the development of granulomatous lesions. Folia Histochem Cytobiol 53: 294-306, 2015.
・Nagase H, Takano H, Inoue K, Yamaguchi M, Ohta K. Diesel exhaust particles suppress pathogen-associated molecular pattern-induced cytokine generation from bronchial epithelial cells. Allergol Int 64 Suppl: S74-76, 2015
・Inoue K, Takano H. Epidemiology of asthma exacerbations and their relation with environmental factors in the Basque Country. Clin Exp Allergy 45: 1475, 2015

【2016】
・Tanaka M, Inoue K, Shimada A, Takano H. Ex vivo effects of naphthoquinones on allergen-sensitized mononuclear cells in mice. Int J Immunopathol Pharmacol 29: 461-468, 2016.
・Inoue K. Toxicological biology of particulate matters on allergic pulmonary inflammation. Allergic Diseases: Recent Advances (in press).

【2017】
・Inoue K, Kusama Y, Takano H. A rare gastrointestinal complication of IgG4-related disease. Biomed Res (in press).
・Takano H, Inoue K. Environmental pollution and allergies. J Toxicol Pathol (in press).
・Ikeda M, Inoue K, Kusagaya H. A case of supernumerary intrathoracic rib. Asian Cardiovasc Thorac Ann (in press).
・Takano H, Inoue K. Environmental pollution and allergies. J Toxicol Pathol (in press).
・Inoue K, Takano H. Occupational pesticide exposure and respiratory health. Thorax (in press).
・Inoue K, Takano H. Diesel exhaust particles on coagulatory systems. Brit J Pharmacol (correspondence: in press).


教育・研究に対する考え方

内科的疾患の病態生理等を分かりやすく講義する。また、環境変化に感受性の高い疾患の解明に迫る研究を継続する。


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