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静岡県立大学教員データベース


教員情報詳細


写真:世戸 孝樹

氏名
世戸 孝樹(SETO Yoshiki)
出生年月
1983年5月
所属・職名
薬学部薬学科(薬物動態学分野) 講師
薬学研究院(薬物動態学教室) 講師(兼務)
電話番号
054-264-5632
部屋番号
薬学部棟6108-1号室
Eメールアドレス
seto(ここに@を入れてください)u-shizuoka-ken.ac.jp
ホームページアドレス(URL)
http://w3pharm.u-shizuoka-ken.ac.jp/yakuzai/
研究シーズ集
http://www.u-shizuoka-ken.ac.jp/file/25aseto.pdf

学歴

2007年3月 静岡県立大学薬学部製薬学科卒業
2009年3月 静岡県立大学大学院薬学研究科博士前期課程修了
2012年3月 静岡県立大学大学院薬学研究科博士後期課程修了


学位

博士(医療薬学)(静岡県立大学・2012年)


専門分野

動態制御、安全性


担当科目

医療系薬学実習


主要研究テーマ

・医薬品創製のための薬剤性光線過敏症評価のためのツール開発
・薬剤性光線過敏症発症に関するTK/TD解析


所属学会

日本薬学会
日本薬剤学会
日本薬物動態学会
日本毒性学会
日本動物実験代替法学会
日本医薬品安全性学会
日本DDS学会
Society of Toxicology


主な経歴

2012年4月 科研製薬株式会社 総合研究所 薬物動態・安全性研究部
2014年8月 静岡県立大学薬学部 助教
2017年4月 静岡県立大学薬学部 講師


主な社会活動

  


主要研究業績

○原著論文
1) Development of an improved inhalable powder formulation of pirfenidone by spray-drying: in vitro Characterization and pharmacokinetic profiling, Seto Y, Suzuki G, Sharon SSY, Chan HK, Onoue S, Pharmaceutical Research, 2016, in press (DOI: 10.1007/s11095-016-1887-3)
2) Comparative study on prediction performance of photosafety testing tools on photoallergens, Onoue S, Ohtake H, Suzuki G, Hirota M, Nishida H, Ashikaga T, Kouzuki H, Seto Y, Toxicology in Vitro, 2016, in press
3) Photochemical mechanism of riboflavin-induced degradation of famotidine and a suggested pharmaceutical strategy for improving photostability, Uchida A, Onoue S, Ohtake H, Seto Y, Teramatsu T, Terajima T, Oguchi T, Journal of Pharmaceutical Sciences, 105(2): 741–746, 2016
4) Low hygroscopic spray-dried powders with trans-glycosylated food additives enhance the solubility and oral bioavailability of ipriflavone, Fujimori M, Kadota K, Kato K, Seto Y, Onoue S, Sato H, Ueda H, Tozuka Y, Food Chemistry, 190: 1050–1055, 2016
5) New photosafety assessment strategy based on the photochemical and pharmacokinetic properties of both parent chemicals and metabolites, Kato M, Suzuki G, Ohtake H, Seto Y, Onoue S, Drug Metabolism and Disposition, 43(11): 1815–1822, 2015
6) Non-animal photosafety screening for complex cosmetic ingredients with photochemical and photobiochemical assessment tools, Nishida H, Hirota M, Seto Y, Suzuki G, Kato M, Sugiyama M, Kouzuki H, Onoue S, Regulatory Toxicology and Pharmacology, 72(3): 578–585, 2015
7) Phototoxic risk assessments on benzophenone derivatives: Photobiochemical assessments and dermal cassette-dosing pharmacokinetic study, Seto Y, Ohtake H, Kato M, Onoue S, The Journal of Pharmacology and Experimental Therapeutics, 354(2): 195–202, 2015
8) Self-nanoemulsifying particles of coenzyme Q10 with improved nutraceutical potential, Onoue S, Uchida A, Nakamura T, Kuriyama K, Hatanaka J, Tanaka T, Miyoshi H, Seto Y, Yamada S, PharmaNutrition, 3: 153–159, 2015
9) Photosafety screening of phenothiazine derivatives with combined use of photochemical and cassette-dosing pharmacokinetic data, Onoue S, Kato M, Inoue R, Seto Y, Yamada S, Toxicological Sciences, 137 (2): 469-477, 2014
10) Development of micellar reactive oxygen species assay for photosafety evaluation of poorly water-soluble chemicals, Seto Y, Kato M, Yamada S, Onoue S, Toxicology in Vitro, 27 (6): 1838-1846, 2013
11) Inhalable powder formulation of pirfenidone with reduced phototoxic risk for treatment of pulmonary fibrosis, Onoue S, Seto Y, Kato M, Aoki Y, Kojo Y, Yamada S, Pharmaceutical Research, 30 (6): 1586-1596, 2013
12) Photosafety assessments on pirfenidone: photochemical, photobiological, and pharmacokinetic characterization, Seto Y, Inoue R, Kato M, Yamada S, Onoue S, Journal of Photochemistry and Photobiology B: Biology, 120: 44-51, 2013
13) Establishment and intra-/inter-laboratory validation of a standard protocol of reactive oxygen species assay for chemical photosafety evaluation, Onoue S, Hosoi K, Wakuri S, Iwase Y, Yamamoto T, Matsuoka N, Nakamura K, Toda T, Osaki N, Matsumoto Y, Kawakami S, Seto Y, Kato M, Yamada S, Ohno Y, Kojima H, Journal of Applied Toxicology, 33 (11): 1241-1250, 2012
14) Novel solid self-emulsifying drug delivery system of coenzyme Q10 with improved photochemical and pharmacokinetic behaviors, Onoue S, Uchida A, Kuriyama K, Nakamura T, Seto Y, Kato M, Hatanaka J, Tanaka T, Miyoshi H, Yamada S, European Journal of Pharmaceutical Sciences, 46 (5): 492-499, 2012
15) In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts, Onoue S, Seto Y, Ochi M, Inoue R, Ito H, Hatano T, Yamada S, Phytochemistry, 72 (14-15): 1814-1820, 2011
16) Combined use of in vitro phototoxic assessments and cassette dosing pharmacokinetic study for phototoxicity characterization of fluoroquinolones, Seto Y, Inoue R, Ochi M, Gandy G, Yamada S, Onoue S, AAPS Journal, 13 (3): 482-492, 2011
17) Pharmacokinetic study of nicotine and its metabolite cotinine to clarify possible association between smoking and voiding dysfunction in rats using UPLC/ESI-MS, Onoue S, Yamamoto N, Seto Y, Yamada S, Drug Metabolism and Pharmacokinetics, 26 (4): 416-422, 2011
18) Development of high-energy amorphous solid dispersion of nanosized nobiletin, a citrus polymethoxylated flavone, with improved oral bioavailability, Onoue S, Uchida A, Takahashi H, Seto Y, Ogawa K, Yuminoki K, Hashimoto N, Yamada S, Journal of Pharmaceutical Sciences, 100 (9): 3793-3801, 2011
19) In vitro photobiochemical characterization of sulfobutylether--cyclodextrin formulation of bufexamac, Seto Y, Ochi M, Igarashi N, Inoue R, Oishi A, Toida T, Yamada S, Onoue S, Journal of Pharmaceutical and Biomedical Analysis, 55 (3): 591-596, 2011
20) High-throughput screening strategy for photogenotoxic potential of pharmaceutical substances using fluorescent intercalating dye, Seto Y, Ochi M, Onoue S, Yamada S, Journal of Pharmaceutical and Biomedical Analysis, 52 (5): 781-786, 2010
21) High-throughput screening system for identifying phototoxic potential of drug candidates based on derivatives of reactive oxygen metabolites, Onoue S, Ochi M, Gandy G, Seto Y, Igarashi N, Yamauchi Y, Yamada S, Pharmaceutical Research, 27 (8): 1610-1619, 2010
22) A possible mechanism for the decrease in serum thyroxine level by a 2,3,7,8-tetrachlorodibenzo-p-dioxin-like polychlorinated biphenyl congener, 3,3',4,4',5-pentachlorobiphenyl in mice, Kato Y, Haraguchi K, Kubota M, Seto Y, Okura T, Ikushiro S, Koga N, Yamada S, Degawa M, Drug Metabolism and Disposition, 38 (1): 150-156, 2010
23) Formulation design and photochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability, Onoue S, Takahashi H, Kawabata Y, Seto Y, Hatanaka J, Timmermann B, Yamada S, Journal of Pharmaceutical Sciences, 99 (4): 1871-1881, 2010
24) 4-Hydroxy-2,2',3,4',5,5',6-heptachlorobiphenyl-mediated decrease in serum thyroxine level in mice occurs through increase in accumulation of thyroxine in the liver, Kato Y, Haraguchi K, Kubota M, Seto Y, Ikushiro S, Sakaki T, Koga N, Yamada S, Degawa M, Drug Metabolism and Disposition, 37 (10): 2095-2102, 2009
25) Novel methodology for predicting photogenotoxic risk of pharmaceutical substances based on reactive oxygen species (ROS) and DNA-binding assay, Onoue S, Seto Y, Oishi A, Yamada S, Journal of Pharmaceutical Sciences, 98 (10): 3647-3658, 2009
26) In vitro/in vivo phototoxic risk assessments of griseofulvin based on photobiochemical and pharmacokinetic behaviors, Seto Y, Onoue S, Yamada S, European Journal of Pharmaceutical Sciences, 38 (2): 104-111, 2009
27) Reactive oxygen species assay-based risk assessment of drug-induced phototoxicity: classification criteria and application to drug candidates, Onoue S, Kawamura K, Igarashi N, Zhou Y, Fujikawa M, Yamada H, Tsuda Y, Seto Y, Yamada S, Journal of Pharmaceutical and Biomedical Analysis, 47 (4-5): 967-972, 2008

○総説
1) Pharmacokinetic and pharmacodynamics perspectives on druggability of inhaled peptides/proteins, Onoue S, Suzuki H, Seto Y, Current Pharmaceutical Design, 21(27): 3867–3874, 2015
2) Exploratory and Regulatory Assessments on Photosafety of New Drug Entities, Seto Y, Hosoi K, Takagi H, Nakamura K, Kojima H, Yamada S, Onoue S, Current Drug Safety, 7 (2): 140-148, 2012
3) Drug-induced phototoxicity; an early in vitro identification of phototoxic potential of new drug entities in drug discovery and development, Onoue S, Seto Y, Gandy G, Yamada S, Current drug Safety, 4 (2): 123-136, 2009


教育・研究に対する考え方

人の生命に関わるという倫理観と使命感を持つ研究者・医療従事者として基礎研究・臨床で活躍できる人材育成に注力したい。


研究シーズ集に関するキーワード

薬剤性光線過敏症、薬物動態、光安全性、光反応性、活性酸素種、動態制御


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