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静岡県立大学教員データベース


教員情報詳細


氏名
玉野 春南(TAMANO Haruna)
所属・職名
薬学部薬科学科(統合生理学分野) 特任講師
薬学研究院(統合生理学教室) 特任講師(兼務)
電話番号
054-264-5732
部屋番号
薬学部棟6513号室
Eメールアドレス
tamano(ここに@を入れてください)u-shizuoka-ken.ac.jp
ホームページアドレス(URL)
http://w3pharm.u-shizuoka-ken.ac.jp/bioorg/saito/Home.html

学歴

1991年3月 静岡県立大学薬学部薬学科卒業
1993年3月 静岡県立大学薬学研究科修士課程修了


学位

博士(薬学)(静岡県立大学・ 2001年)


専門分野

神経科学、生理学


担当科目

機能形態生理学Ⅱ、ペプチド科学、統合生理学特論


主要研究テーマ

・生体微量金属に着目したストレス性神経障害のメカニズムとその予防
・亜鉛と記憶
・牡蠣に含まれる生理活性物質の脳機能に対する作用解析


所属学会

日本薬学会
日本微量元素学会
日本神経科学学会
Society for Neuroscience
International Society for Zinc Biology
World Oyster Society


主な経歴

1993年4月 アマシャム株式会社(現 GEヘルスケア・ジャパン株式会社)
1999年4月 理化学研究所加速器基盤研究部 奨励研究員
2001年4月 静岡県立大学薬学部医薬生命化学分野 客員共同研究員
2012年4月 静岡県立大学薬学部生物薬品化学分野 客員共同研究員
2012年7月 静岡県立大学薬学部 特任助教
2015年4月 静岡県立大学薬学部 特任講師


受賞歴

2007年 メタルバイオサイエンス研究会 研究奨励賞


主な社会活動

 


主要研究業績

○原著論文(58報):
1. Haruna Tamano, Ryusuke Nishio, Yukina Shakushi, Miku Sasaki, Yuta Koike, Misa Osawa, Atsushi Takeda: In vitro and in vivo physiology of low nanomolar concentrations of Zn2+ in artificial cerebrospinal fluid. Sci. Rep. in press.
2. Atsushi Takeda, Haruna Tamano, Marie Hisatsune, Taku Murakami, Hiroyuki Nakada, Hiroaki Fujii: Maintained LTP and memory are lost by Zn2+ influx into dentate granule cells, but not Ca2+ influx. Mol Neurobiol. in press.
3. Yuki Fujise, Mitsuyasu Kubota, Miki Suzuki, Haruna Tamano, Atsushi Takeda: Blockade of intracellular Zn signaling in the basolateral amygdala affects object recognition memory via attenuation of dentate gyrus LTP. Neurochem. Int. in press.
4. Haruna Tamano, Kazuki Ide, Paul Anthony Adlard, Ashley Ian Bush, and Atsushi Takeda: Involvement of hippocampal excitability in amyloid β-induced behavioral and psychological symptoms of dementia. J. Toxicol. Sci., 41, 449-457 (2016).
5. Haruna Tamano, Yusuke Enya, Kazuki Ide, Atsushi Takeda: Influences of Yokukansankachimpihange on aggressive behavior of zinc-deficient mice and actions of the ingredients on excessive neural exocytosis in the hippocampus of zinc-deficient rats. Exp Anim, 65, 353-361 (2016).
6. Hanuna Tamano, Yuta Koike, Hiroyuki Nakada, Yukina Shakushi, and Atsushi Takeda: Significance of synaptic Zn2+ signaling in zincergic and non-zincergic synapses in the hippocampus in cognition. J. Trace Elem. Med. Biol., 38, 93-98 (2016).
7. Atsushi Takeda, Haruna Tamano, Ryusuke Nishio, and Taku Murakami: Behavioral abnormality induced by enhanced hypothalamo-pituitary-adrenocortical axis activity under dietary zinc deficiency and its usefulness as models. Int. J. Mol. Sci., 17, 1149 (2016).
8. Haruna Tamano, Yukina Shakushi, Mitsugu Watanabe, Kazumi Ohashi, Chiharu Uematsu, Tadamune Otsubo, Kiyoshi Ikeda, Atsushi Takeda: Preventive effect of 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA) and zinc, components of the pacific oyster crassostrea gigas, on glutamatergic neuron activity in the hippocampus. Biol. Bull., 229, 282-288 (2015).
9. Atsushi Takeda, Yukina Shakushi, Haruna Tamano: Modification of hippocampal excitability in brain slices pretreated with a low nanomolar concentration of Zn2+. J Neurosci. Res., 93, 1641-1647 (2015).
10. Atsushi Takeda, Miki Suzuki, Munekazu Tempaku, Kazumi Ohashi, Haruna Tamano: Influx of extracellular Zn2+ into the hippocampal CA1 neurons is required for cognitive performance via long-term potentialion. Neuroscience, 304, 209-216 (2015).
11. Miki Suzuki, Yuki Fujise, Yuka Tsuchiya, Haruna Tamano, Atsushi Takeda: Excess influx of Zn2+ into dentate granule cells affects object recognition memory via attenuated LTP. Neurochem. Int., 87, 60-65 (2015).
12. Haruna Tamano, Tatsuya Minamino, Hiroaki Fujii, Shunsuke Takada, Masaki Ando, Atsushi Takeda: Blockade of intracellular Zn2+ signaling in the dentate gyrus erases recognition memory via impairment of maintained LTP. Hippocampus, 25, 952-962 (2015).
13. Atsushi Takeda, Masatoshi Nakamura, Hiroaki Fujii, Chihiro Uematsu, Tatsuya Minamino, Paul Anthony Adlard, Ashley Ian Bush, Haruna Tamano: Amyloid β-mediated Zn2+ influx into dentate granule cells transiently induces a short-term cognitive deficit. PLoS One, 9, e115923 (2014).
14. Haruna Tamano, Kotaro Fukura, Miki Suzuki, Kazuhiro Sakamoto, Hidehiko Yokogoshi, Atsushi Takeda: Advantageous effect of theanine intake on cognition. Nutritional Neurosci., 17, 279-83 (2014).
15. Atsushi Takeda, Haruna Tamano, Taisuke Ogawa, Shunsuke Takada, Masatoshi Nakamura, Hiroaki Fujii and Masaki Ando: Intracellular Zn2+ signaling in the dentate gyrus is required for object recognition memory. Hippocampus, 24, 1404-1412 (2014).
16. Haruna Tamano, Kotaro Fukura, Miki Suzuki, Kazuhiro Sakamoto, Hidehiko Yokogoshi, Atsushi Takeda: Preventive effect of theanine intake on stress-induced impairments of hippocamapal long-term potentiation and recognition memory. Brain Res. Bull., 95, 1-6 (2013).
17. Atsushi Takeda, Masashi Iida, Masaki Ando, Masatoshi Nakamura, Haruna Tamano and Naoto Oku: Enhanced susceptibility to spontaneous seizures of noda epileptic rats by loss of synaptic Zn2+. PLoS One, 8, e71372 (2013).
18. Atsushi Takeda, Haruka Iwaki, Kazuki Ide, Haruna Tamano and Naoto Oku: Therapeutic effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient and pair-fed mice. Brain Res. Bull., 87, 551-5 (2012).
19. Atsushi Takeda, Haruna Tamano, Taisuke Ogawa, Shunsuke Takada, Masaki Ando, Naoto Oku and Mitsugu Watanabe: Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency. Behav. Brain Res., 226, 259-64 (2012).
20. Atsushi Takeda, Miki Suzuki, Haruna Tamano, Shunsuke Takada, Kazuki Ide and Naoto Oku: Involvement of glucocorticoid-mediated Zn2+ signaling in attenuation of hippocampal CA1 LTP by acute stress. Neurochem. Int., 60, 394-399 (2012).
21. Atsushi Takeda, Haruna Tamano, Miki Suzuki, Kazuhiro Sakamoto, Naoto Oku, Hidehiko Yokogoshi: Unique induction of CA1 LTP components after intake of theanine, an amino acid in tea leaves and its effect on stress response. Cell. Mol. Neurobiol., 32, 41-48 (2012).
22. Atsushi Takeda, Haruna Tamano, Miki Suzuki, Kazuhiro Sakamoto, Naoto Oku and Hidehiko Yokogoshi: Unique induction of CA1 LTP components after intake of theanine, an amino acid in tea leaves and its effect on stress response. Cell Mol. Neurobiol., 32, 41-48 (2011).
23. Atsushi Takeda, Shunsuke Takada, Masatoshi Nakamura, Miki Suzuki, Haruna Tamano, Masaki Ando and Naoto Oku: Transient increase in Zn2+ in hippocampal CA1 pyramidal neurons causes reversible memory deficit. PLoS One, 6(12), e28015 (2011).
24. Atsushi Takeda, Kazuhiro Sakamoto, Haruna Tamano, Kouichiro Fukura, Naoto Inui, Sang Won Suh, Won Seok-Joon and Hidehiko Yokogoshi. Facilitated neurogenesis in the developing hippocampus after intake of theanine, an amino acid in tea leaves, and object recognition memory. Cell Mol. Neurobiol. 31, 1079-88 (2011).
25. Atsushi Takeda, Shunsuke Takada, Masaki Ando, Kosuke Itagaki, Haruna Tamano, Miki Suzuki, Haruka Iwaki and Naoto Oku: Impairment of recognition memory and hippocampal long-term potentiation after acute exposure to clioquinol. Neuroscience, 171, 443-450 (2010).
26. Haruna Tamano, Fumika Kan, Naoto Oku and Atsushi Takeda: Ameliorative effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient young mice. Brain Res. Bull., 83, 351-355 (2010).
27. Atsushi Takeda, Miki Suzuki, Haruna Tamano, Masaki Ando and Naoto Oku: Differential effects of zinc influx via AMPA/kainate receptor activation on subsequent induction of hippocampal CA1 LTP components. Brain Res., 1354, 188-195 (2010).
28. Atsushi Takeda, Haruna Tamano, Sachie Imano, Naoto Oku: Increases in extracellular zinc in the amygdala in acquisition and recall of fear experience and their roles in response to fear. Neuroscience, 168, 715-722 (2010).
29. Mitsugu Watanabe, Haruna Tamano, Toshinori Kikuchi and Atsushi Takeda: Susceptibility to stress in young rats after 2-week zinc deprivation. Neurochem. Int. 56, 410-416 (2010).
30. Sang Won Suh, Seok Joon Won, Aaron M Hamby, Byung Hoon Yoo, Yang Fan, Christian T Sheline, Haruna Tamano, Atsushi Takeda and Jialing Liu: Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats. J. Cereb. Blood Flow Metab., 29, 1579-1588 (2009).
31. Haruna Tamano, Fumika Kan, Mika Kawamura, Naoto Oku and Atsushi Takeda: Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation. Neurochem. Int., 55, 536-541(2009).
32. Atsushi Takeda, Haruna Tamano, Hiromasa Itoh and Naoto Oku: Attenuation of abnormal glutamate release in zinc deficiency by zinc and Yokukansan. Neurochem. Int., 53, 230-235 (2008).
33. Atsushi Takeda, Hiromasa Itoh, Kohei Yamada, Haruna Tamano and Naoto Oku: Enhancement of hippocampal mossy fiber activity in zinc deficiency and its influence on behavior. Biometals, 21, 545-552 (2008).
34. Atsushi Takeda, Haruna Tamano, Fumika Kan, Tomoyuki Hanajima, Kohei Yamada, and Naoto Oku: Enhancement of social isolation-induced aggressive behavior of young mice by zinc deficiency. Life Sci., 82, 909-914 (2008).
35. Atsushi Takeda, Hiromasa Itoh, Haruna Tamano, Mitsutoshi Yuzurihara and Naoto Oku: Suppressive effect of Yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats. Nutr. Neurosci., 11, 41-46 (2008).
36. Atsushi Takeda, Kohei Yamada, Haruna Tamano, Sayuri Fuke, Mika Kawamura and Naoto Oku: Hippocampal calcium dyshomeostasis and long-term potentiation in 2-week zinc deficiency. Neurochem. Int., 52, 241-246 (2008).
37. Atsushi Takeda, Haruna Tamano, Fumika Kan, Hiromasa Itoh and Naoto Oku: Anxiety-like behavior of young rats after 2-week zinc deprivation. Behav. Brain Res., 177, 1-6 (2007).
38. Atsushi Takeda, Hiromasa Itoh, Haruna Tamano and Naoto Oku: Responsiveness to kainate in young rats after 2-week zinc deprivation. Biometals, 19, 565-572 (2006).
39. Atsushi Takeda, Haruna Tamano, Akito Nagayoshi, Kohei Yamada and Naoto Oku: Increase in hippocampal cell death after treatment with kainate in zinc deficiency. Neurochem. Int., 47, 539-544 (2005).
40. Atsushi Takeda, Haruna Tamano and Naoto Oku: Involvement of unusual glutamate release in kainate-induced seizures in zinc-deficient adult rats. Epilepsy Res., 66, 137-143 (2005)
41. Atsushi Takeda, Haruna Tamano, and Yuko Ibuki: Change of zinc uptake under growth arrest and apoptosis. Anticancer Res., 24, 3869-3874 (2004).
42. Atsushi Takeda, Haruna Tamano, Minori Tochigi and Naoto Oku: Zinc homeostasis in the hippocampus of zinc-deficient young adult rats. Neurochem. Int., 46, 221-225 (2004).
43. Haruna Tamano and Atsushi Takeda: Suppressive effect of Saiko-ka-ryukotsu-borei-to, a herbal medicine, on excessive release of glutamate in the hippocampus. Brain Res. Bull., 64, 273-277 (2004).
44. Atsushi Takeda, Maki Hirate, Haruna Tamano and Naoto Oku: Zinc movement in the brain under kainate-induced seizures. Epilepsy Res., 54, 123-129 (2003).
45. Atsushi Takeda, Maki Hirate, Haruna Tamano, Nishibaba Daisuke and Naoto Oku: Susceptibility to kainate-induced seizures under dietary zinc deficiency. J. Neurochem., 85, 1575-1580 (2003).
46. Atsushi Takeda, Maki Hirate, Haruna Tamano and Naoto Oku: Release of glutamate and GABA in the hippocampus under zinc deficiency. J. Neurosci. Res.,72, 537-542 (2003).
47. Atsushi Takeda, Haruna Tamano and Naoto Oku: Alteration of zinc concentrations in the brain implanted with C6 glioma. Brain Res., 965, 170-173 (2003).
48. Maki Hirate, Atsushi Takeda, Haruna Tamano, Shuichi Enomoto, and Naoto Oku: Distribution of trace elements in the brain of EL(epilepsy) mice. Epilepsy Res., 51 109-116 (2002).
49. Haruna Tamano, Shuichi Enomoto, Naoto Oku and Atsushi Takeda: Preferential uptake of zinc, manganese, and rubidium in rat brain tumor. Nucl. Med. Biol., 29, 109-116 (2002).
50. Atsushi Takeda, Haruna Tamano, Shuichi Enomoto and Naoto Oku: Zinc-65 imaging of rat brain tumors. Cancer Res., 61, 5065-5069 (2001).
51. Haruna Tamano, Bin Liu, Shuichi Enomoto and Atsushi Takeda: Tumor accumulation of radioactive trace elements: A multutracer study. Biomed. Res. Trace Elements, 12, 96-101 (2001).
52. Haruna Tamano, Shuichi Enomoto, Emi Igasaki, Naoto Oku, Norio Itoh, Tomoki Kimura, Keiichi Tanaka and Atsushi Takeda: Hepatic zinc response via metallothionein induction after tumor transplantation. Biochem. Biophys. Res. Commun., 270, 1140-1143 (2000).
53. Atsushi Takeda, Kazuhiko Goto, Tetsu Sato, Haruna Tamano and Shoji Okada: Zinc-specific response in metallothionein induction in liver of tumor-bearing mice. J. Trace Elem. Exp. Med., 10, 243-248 (1997).
54. Atsushi Takeda, Haruna Tamano, Miho Ohnuma and Shoji Okada: 65Zn uptake by liver of rats fed 3'-methyl-dimethylaminoazobenzene. Nucl. Med. Biol., 22, 351-353 (1995).
55. Atsushi Takeda, Haruna Tamano, Tetsu Sato, Kazuhiko Goto and Shoji Okada: Characteristic induction of hepatic metallothionein in mice by tumor transplantation. Biochim. Biophys. Acta, 1243, 325-328 (1995).
56. Atsushi Takeda, Haruna Tamano and Shoji Okada: Differential hepatic response of 65Zn distribution between mice bearing experimental tumor and inflammation. Nucl. Med. Biol., 22,133-136 (1995).
57. Atsushi Takeda, Haruna Tamano, Akihiko Hoshino and Shoji Okada: Elevation of hepatic levels of metallothionein during experimental carcinogenesis. Biol. Trace Elem. Res., 41, 157-164 (1994).
58. Atsushi Takeda, Tetsu Sato, Haruna Tamano and Shoji Okada: Elevation of hepatic levels of metallothionein and zinc in experimental tumor-bearing murines. Biochem. Biophys. Res. Commun., 189, 645-649 (1992).

○総説(15報)
1. Atsushi Takeda and Hanuna Tamano: Insight into cognitive decline from Zn2+ dynamics through extracellular signaling of glutamate and glucocorticoids. Arch. Biochem. Biophys., 611, 93-99 (2016).
2. Atsushi Takeda and Hanuna Tamano: Innervation from the entorhinal cortex to the dentate gyrus and the vulnerability to Zn2+. J. Trace Elem. Med. Biol., 38, 19-23 (2016).
3. Atsushi Takeda and Haruna Tamano: Significance of low nanomolar concentration of Zn2+ in artificial cerebrospinal fluid. Mol. Neurobiol., Mar 16, PMID: 26984599 (2016).
4. Atsushi Takeda and Haruna Tamano: Significance of the degree of synaptic Zn2+ signaling in cognition. Biometals, 29, 177-185 (2016).
5. Haruna Tamano and Atsushi Takeda: Is interaction of amyloid β-peptides with metals involved in cognitive activity? Metallomics, 7, 1205-1212 (2015).
6. Atsushi Takeda and Haruna Tamano: Regulation of extracellular Zn2+ homeostasis in the hippocampus as a therapeutic target for Alzheimer’s disease. Expert Opinion on Therapeutic Targets, 19, 1051-1058 (2015).
7. Atsushi Takeda and Haruna Tamano: Cognitive decline due to excess synaptic Zn2+ signaling in the hippocampus. Frontiers in Aging Neuroscience, 6:26 (2014).
8. Atsushi Takeda and Haruna Tamano: Intracellular Zn2+ signaling in cognition. J. Neurosci. Res., 92, 819-24 (2014).
9. Atsushi Takeda, Hiroaki Fujii, Tatsuya Minamino, Haruna Tamano: Intracellular Zn2+ signaling in cognition. J. Neurosci. Res., 92, 819-824 (2014).
10. Atsushi Takeda, Masatoshi Nakamura, Hiroaki Fujii, Haruna Tamano: Synaptic Zn2+ homeostasis and its significance. Metallomics, 5, 417-423 (2013).
11. Atsushi Takeda and Haruna Tamano: Proposed glucocorticoid-mediated zinc signaling in the hippocampus. Metallomics 4, 614-8 (2012). IF=4.010
12. Haruna Tamano and Atsushi Takeda: Dynamic action of neurometals at the synapse. Metallomics, 3, 656-61 (2011).
13. Atsushi Takeda and Haruna Tamano: Zinc signaling through glucocorticoid and glutamate signaling in stressful circumstances. J. Neurosci. Res., 88, 3002-3010 (2010).
14. Atsushi Takeda and Haruna Tamano: Insight into neurozinc in the hippocampus. Biomed. Res. Trace Elements, 21, 194-203 (2010). IF=0
15. Atsushi Takeda and Haruna Tamano. Insight into zinc signaling from dietary zinc deficiency. Brain Res. Rev., 62, 33-44 (2009).


教育・研究に対する考え方

教育:長所を最大限生かし、不得意分野にも積極的に取り組める教育環境を提供したい。
研究:脳機能における微量金属の生理的役割を明らかにし、認知機能障害や精神障害の予防や治療を目指したい。


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