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静岡県立大学教員データベース


教員情報詳細


写真:山口 賢彦

氏名
山口 賢彦(YAMAGUCHI Masahiko)
出生年月
1984年11月
所属・職名
薬学部薬学科(生体情報分子解析学分野) 助教
電話番号
054-264-5776
部屋番号
薬学部棟6614号室
Eメールアドレス
masahiko-y(ここに@を入れてください)u-shizuoka-ken.ac.jp
ホームページアドレス(URL)
http://w3pharm.u-shizuoka-ken.ac.jp/rinsho/

学歴

2007年3月 静岡県立大学薬学部製薬学科卒業
2012年3月 大阪大学大学院薬学研究科博士課程修了


学位

博士(薬学)(大阪大学・2012年)


専門分野

細胞生物学、分子生物学


担当科目

臨床検査学、医療系薬学実習、生体情報分子解析学特論、医用工学実習


主要研究テーマ

・PAF受容体シグナリングにおける新たな生理機能の解明
・核内受容体PXRを介したUGT1A1発現調節機構の解析


所属学会

日本薬学会
日本再生医療学会
日本分子生物学会
脂質生化学会


主な経歴

2012年4月 静岡県立大学薬学部 助教


主な社会活動

 


主要研究業績

○原著論文
(1) Sugatani J, Noguchi Y, Hattori Y, Yamaguchi M, Yamazaki Y, Ikari A.:
Threonine-408 Regulates the Stability of the Human Pregnane X Receptor Through its Phosphorylation and the CHIP/Chaperone-Autophagy Pathway.
Drug Metab Dispos., pii: dmd.115.066308 (2015)
(2) Yamaguchi M, Watanabe Y, Ohtani T, Uezumi A, Mikami N, Nakamura M, Sato T, Ikawa M, Hoshino M, Tsuchida K, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H, Fukada S.:
Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche.
Cell Rep., 13, 302-314 (2015)
(3) Ikari A, Taga S, Watanabe R, Sato T, Shimobaba S, Sonoki H,Endo S, Matsunaga T, Sakai H, Yamaguchi M, Yamazaki Y, Sugatani J.:
Clathrin-dependent endocytosis of claudin-2 by DFYSP peptide causes lysosomal damage in lung adenocarcinoma A549 cells.
Biochim Biophys Acta., 1848, 2326-2336 (2015)
(4) Yamaguchi M, Murakami S, Yoneda T, Nakamura M, Zhang L, Uezumi A, Fukuda S, Kokubo H, Tsujikawa K, Fukada S.:
Evidence of Notch-Hesr-Nrf2 Axis in Muscle Stem Cells, but Absence of Nrf2 Has No Effect on Their Quiescent and Undifferentiated State.
Plos One., 10, e0138517 (2015)
(5) Sonoki H, Sato T, Endo S, Matsunaga T, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A.:
Quercetin Decreases Claudin-2 Expression Mediated by Up-Regulation of microRNA miR-16 in Lung Adenocarcinoma A549 Cells.
Nutrients., 7, 4578-4592 (2015)
(6) Yamazaki Y, Yasui K, Hashizume T, Suto A, Mori A, Murata Y, Yamaguchi M, Ikari A, Sugatani J.:
Involvement of a cyclic adenosine monophosphate-dependent signal in the diet-induced canalicular trafficking of adenosine triphosphate-binding cassette transporter g5/g8.
Hepatology., 62, 1215-1226 (2015)
(7) Ikari A, Fujii N, Hahakabe S, Hayashi H, Yamaguchi M, Yamazaki Y, Endo S, Matsunaga T, Sugatani J.: Hyperosmolarity-Induced Down-Regulation of Claudin-2 Mediated by Decrease in PKCβ-Dependent GATA-2 in MDCK Cells.
J Cell Physiol., 230, 2776-2787 (2015)
(8) Yamaguchi M, Matsui M, Higa R, Yamazaki Y, Ikari A, Miyake M, Miwa M, Ishii S, Sugatani J, Shimizu T.
A platelet-activating factor (PAF) receptor deficiency exacerbates diet-induced obesity but PAF/PAF receptor signaling does not contribute to the development of obesity-induced chronic inflammation.
Biochem Pharmacol. 2015 Feb 15;93(4):482-95.
(9) Ogawa R, Ma Y, Yamaguchi M, Ito T, Watanabe Y, Ohtani T, Murakami S, Uchida S, De Gaspari P, Uezumi A, Nakamura M, Miyagoe-Suzuki Y, Tsujikawa K, Hashimoto N, Braun T, Tanaka T, Takeda S, Yamamoto H, Fukada S.
Doublecortin marks a new population of transiently amplifying muscle progenitor cells and is required for myofiber maturation during skeletal muscle regeneration.
Development. 2015 Jan 1;142(1):51-61.
(10) Sugatani J, Hattori Y, Noguchi Y, Yamaguchi M, Yamazaki Y, Ikari A.
Threonine-290 regulates nuclear translocation of the human pregnane X receptor through its phosphorylation/dephosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1.
Drug Metab Dispos. 2014 Oct;42(10):1708-18.
(11) Ikari A, Watanabe R, Sato T, Taga S, Shimobaba S, Yamaguchi M, Yamazaki Y, Endo S, Matsunaga T, Sugatani J.
Nuclear distribution of claudin-2 increases cell proliferation in human lung adenocarcinoma cells.
Biochim Biophys Acta. 2014 Sep;1843(9):2079-88.
(12) Ikari A, Tonegawa C, Sanada A, Kimura T, Sakai H, Hayashi H, Hasegawa H, Yamaguchi M, Yamazaki Y, Endo S, Matsunaga T, Sugatani J.
Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells.
J Biol Chem. 2014 May 9;289(19):13112-23.
(13) Sugatani J, Sadamitsu S, Yamaguchi M, Yamazaki Y, Higa R, Hattori Y, Uchida T, Ikari A, Sugiyama W, Watanabe T, Ishii S, Miwa M, Shimizu T.
Antiobese function of platelet-activating factor: increased adiposity in platelet-activating factor receptor-deficient mice with age.
FASEB J. 2014 Jan;28(1):440-52.
(14) Kanagawa M, Yu C, Ito C, Fukada S, Hozoji-Inada M, Chiyo T, Kuga A, Matuo M, Sato K, Yamaguchi M, Ito T, Katanosaka Y, Miyagoe-Suzuki Y, Naruse K, Kobayashi K, Okada T, Takeda S, Toda T:
Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression.
Human Molecular Genetics, 2013 Aug;22(15):3003-15.
(15) Yamazaki Y, Yasuda K, Matsuyama T, Ishihara T, Higa R, Sawairi T, Yamaguchi M, Egi M, Akai S, Miyase T, Ikari A, Miwa M, Sugatani J.
A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice.
Biochem Pharmacol. 2013 Sep 1;86(5):632-44.
(16) Ikari A, Atomi K, Yamazaki Y, Sakai H, Hayashi H, Yamaguchi M, Sugatani J.
Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation.
Biochim Biophys Acta. 2013 Dec;1833(12):2617-27.
(17) Sugatani J, Uchida T, Kurosawa M, Yamaguchi M, Yamazaki Y, Ikari A, Miwa M.
Regulation of Pregnane X Receptor (PXR) Function and UGT1A1 Gene Expression by Posttranslational Modification of PXR Protein.
Drug Metab Dispos. 2012 Oct;40(10):2031-40.
(18) Yamaguchi M, Ogawa R, Watanabe Y, Uezumi A, Miyagoe-Suzuki Y, Tsujikawa K, Yamamoto H, Takeda S, Fukada SI.
Calcitonin receptor and Odz4 are differently expressed in Pax7-positive cells during skeletal muscle regeneration.
J Mol Histol. 2012 Oct;43(5):581-7
(19) Fukada S, Yamaguchi M, Kokubo H, Ogawa R, Uezumi A, Yoneda T, Matev MM, Motohashi N, Ito T, Zolkiewska A, Johnson RL, Saga Y, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H.
Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.
Development. 2011 Nov;138(21):4609-19.
(20) Uezumi A, Ito T, Morikawa D, Shimizu N, Yoneda T, Segawa M, Yamaguchi M, Ogawa R, Matev MM, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Tsuchida K, Yamamoto H, Fukada S.
Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle.
J Cell Sci. 2011 Nov 1;124(Pt 21):3654-64.
(21) Fukada S, Morikawa D, Yamamoto Y, Yoshida T, Sumie N, Yamaguchi M, Ito T, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Yamamoto H.
Genetic background affects properties of satellite cells and mdx phenotypes.
Am J Pathol. 2010 May;176(5):2414-24.

○総説・著書
(1) Yamaguchi M, Fukada S.
Regulation of muscle stem cell quiescence and undifferentiated state: The role of Hesr1 and Hesr3.
TUMOR DORMANCY, QUIESCENCE, AND TISSUE SENESCENCE (eds. M.A. Hayat), Springer Book, (invited Review) 2013, Volume 1, p107-116, Springer, ISBN 978-94-007-5957-2
(2) Fukada S, Yamaguchi M.
Molecular mechanisms for maintaining muscle stem cells by quiescence-stage specific genes.
Frontiers in Skeletal Muscle Wasting, Regeneration and Stem Cell, Frontiers in Physiology (eds. Carlos Hermano da Justa Pinheiro, Lucas Guimaraes-Ferreira) (invited Review).
(3) Watanabe Y, Yamaguchi M, Fukada S.
Molecular regulation of muscle stem cells.
Seitai no Kagaku. 2013, Volume 64, p111-6. ISSN 0370-9531 (Print) ISSN 1883-5503 (Online) (in Japanese)
(4) Yamaguchi M, Otani T, Fukada S.
Transcriptional factor mediated regulatory networks in skeletal muscle development and regeneration.
Seikei Saigaigeka. 2013, Volume 56, p683-8. ISSN 0387-4095 (in Japanese)


教育・研究に対する考え方

教育:薬学部に入学した学生は将来医療に携わる人間であるから、サイエンスに基づいた思考で行動するように育てていきたい。
研究:現在の生物個体は永年の進化を経て非常に洗練された制御機構を有しており、研究によってその一端を垣間見ることはこの上なく愉しいものである。


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