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静岡県立大学教員データベース


教員情報詳細


写真:刀坂 泰史

氏名
刀坂 泰史(KATANASAKA Yasufumi)
出生年月
1980年5月
所属・職名
薬学部薬学科(分子病態学分野) 講師
薬学研究院(分子病態学研究室) 講師(兼務)
部屋番号
薬学部棟6607号室
Eメールアドレス
katana@u-shizuoka-ken.ac.jp
ホームページアドレス(URL)
http://w3pharm.u-shizuoka-ken.ac.jp/byoutai/
研究シーズ集
http://www.u-shizuoka-ken.ac.jp/media/seeds2017_01_030.pdf

学歴

2003年3月 静岡県立大学薬学部製薬学科卒業
2005年3月 静岡県立大学薬学研究科博士前期課程修了
2008年3月 静岡県立大学薬学研究科博士後期課程修了

学位

薬学博士(静岡県立大学・2008年)

専門分野

分子細胞生物学、生化学

担当科目

疾患学1, 2, 3、医療薬学実習、静岡救命連携演習

主要研究テーマ

  • 心不全発症における心筋細胞核内情報伝達機構に関する研究

所属学会

日本薬学会
日本分子生物学会
日本癌学会

主な経歴

2008年4月 国立がんセンター研究所 リサーチレジデント
2010年4月 静岡県立大学薬学部助教
2014年6月 静岡県立大学薬学部講師

主な社会活動

 

主要研究業績

○学術論文
  1. Sano S, Oshima K, Wang Y, MacLauchlan S, Katanasaka Y, Sano M, Zuriaga MA, Yoshiyama M, Goukassian D, Cooper MA, Fuster JJ and Walsh K. Tet2-mediated clonal hematopoiesis accelerates experimental heart failure through an IL-1β/NLRP3 inflammasome mechanism. J Am Coll Cardiol. 2018;71:875-886.
  2. Nakamura K, Sano S, Fuster JJ, Kikuchi R, Shimizu I, Ohshima K, Katanasaka Y, Ouchi N, Walsh K. Secreted frizzled-related protein 5 diminishes cardiac inflammation and protects the heart from ischemia-reperfusion injury. J Biol Chem. 2016;291:2566-2575.
  3. Suzuki H, Katanasaka Y, et al. Tyrosine phosphorylation of RACK1 triggers cardiomyocyte hypertrophy by regulating the interaction between p300 and GATA4. Biochim Biophys Acta. 2016;1862:1544-1557.
  4. Katanasaka Y: Development of Targeted Pharmacotherapy for Cardiovascular Disease. Yakugaku Zasshi. 2017;137:1349-1353.
  5. Katanasaka Y, et al. Regulation of Cardiac Transcription Factor GATA4 by Post-Translational Modification in Cardiomyocyte Hypertrophy and Heart Failure. Int Heart J. 2016;57:672-675.
  6. Miyazaki Y, Katanasaka Y, et al. Effect of statins on atherogenic serum amyloid A and alpha1-antitrypsin low-density lipoprotein complexes. Int J Cardiol. 2016;225:332-336.2
  7. Funamoto M, Sunagawa Y, Katanasaka Y, et al. Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD. Int J Chron Obstruct Pulmon Dis. 2016;11:2029-34.4.
  8. An anti-angiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease. Nature Medicine. 2014;20:1464-1471
  9. Secreted frizzled-related protein 5 diminishes cardiac inflammation and protects the heart from ischemia-reperfusion injury. J Biol Chem. in press.
  10. Effects of statins on left ventricular diastolic function in patients with dyslipidemia and diastolic dysfunction (STAT-LVDF study). Biol Pharm Bull. 2015;38:1404-1409
  11. Colloidal submicron-particle curcumin exhibits high absorption efficiency-a double-blind, 3-way crossover study. Journal of nutritional science and vitaminology. 2015;61:37-44
  12. Optimal Dose-Setting Study of Curcumin for Improvement of Left Ventricular Systolic Function After Myocardial Infarction in Rats. J Pharmacol Sci. in press
  13. Synergistic anti-tumor effects of a novel phosphatidyl inositol-3 kinase/mammalian target of rapamycin dual inhibitor BGT226 and gefitinib in non-small cell lung cancer cell lines. Cancer Lett. 347:196-203, 2014.
  14. Epidermal growth factor receptor variant type iii markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like 4 expression in malignant glioma. Molecular cancer;12:31, 2013
  15. Application of curcumin to heart failure therapy. Biol Pharm Bull; 36: 13-17, 2013.
  16. Enhanced active targeting via cooperative binding of ligands on liposomes to target receptors. PLoS One; 8:e67550, 2013.
  17. Drinkable preparation of Theracurmin exhibits high absorption efficiency--a single-dose, double-blind, 4-way crossover study. Biol Pharm Bull.; 36: 1708-14. 2013
  18. Efficacy of everolimus, a novel mTOR inhibitor, against basal-like triple-negative breast cancer cells. Cancer Sci; 103:1665-71, 2012.
  19. A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heart failure after myocardial infarction in rats. Biol Pharm Bull; 35:139-44, 2012
  20. Sunitinib inhibits lymphatic endothelial cell functions and lymph node metastasis in a breast cancer model through inhibition of vascular endothelial growth factor receptor 3. Breast Cancer Res; 13:R66, 2011.
  21. A natural p300-specific histone acetyltransferase inhibitor, curcumin, in addition to angiotensin converting enzyme inhibitor exerts beneficial effects on left ventricular systolic function after myocardial infarction in rats. Circ J; 75:2151-9, 2011.
  22. Innovative preparation of curcumin for improved oral bioavailability, Biol Pharm Bull; 34:660-5, 2011.
  23. Efficacy of RAD001 (everolimus) against advanced gastric cancer with peritoneal dissemination. Invest New Drugs; 29:660-5, 2011. Cancer antineovascular therapy with liposome drug delivery systems targeted to BiP/GRP78.Int J Cancer. 2010 in press
  24. A novel DDS strategy, "dual-targeting", and its application for antineovascular therapy. Cancer Lett.287(2):165-71,2 010.
  25. Effective delivery of an angiogenesis inhibitor by neovessel-targeted liposomes. Int J Pharm. 360(1-2): 219-24. 2008
  26. Antiangiogenic cancer therapy using tumor vasculature-targeted liposomes encapsulating 3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one, SU5416. Cancer Lett. 270(2): 260-8. 2008
  27. Antineovascular therapy with angiogenic vessel-targeted polyethyleneglycol-shielded liposomal DPP-CNDAC. Cancer Sci. 99(5): 1029-33. 2008
  28. Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown. Biochem Biophys Res Commun. 368(2): 243-8. 2008
  29. Proteomic characterization of angiogenic endothelial cells stimulated with cancer cell-conditioned medium. Biol Pharm Bull. 30(12): 2300-7. 2007
  30. Anti-neovascular therapy by liposomal drug targeted to membrane type-1 matrix metalloproteinase. Int J Cancer. 108(2):301-6. 2004

○著書
  1. 刀坂泰史、森本達也 アンチエイジング医学の基礎と臨床、メジカルビュー社、2015年

教育・研究に対する考え方

教育:学生が自主的かつ積極的に学ぼうとする環境をつくっていきたい。
研究:基礎研究から臨床に還元することを目的とし、実用的な研究を進めていきたい。

研究シーズ集に関するキーワード

心不全,心肥大,p300/GATA4転写経路,クルクミン,エピジェネティクス,天然化合物,機能性食品

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