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静岡県立大学教員データベース


教員情報詳細


写真:井上 和幸

氏名
井上 和幸(INOUE Kazuyuki)
所属・職名
薬学部薬学科(臨床薬効解析学分野) 准教授
薬学研究院(臨床薬効解析学教室) 准教授(兼務)
Eメールアドレス
k-inoue(ここに@を入れてください)u-shizuoka-ken.ac.jp
ホームページアドレス(URL)
http://w3pharm.u-shizuoka-ken.ac.jp/clinphar/
研究シーズ集
http://www.u-shizuoka-ken.ac.jp/file/328.pdf

学歴

1995年3月 東北大学薬学部卒業
1997年3月 東北大学大学院薬学研究科博士課程前期修了


学位

博士(医学)(秋田大学・2004年)


専門分野

医療系薬学


担当科目

静岡の健康長寿を支える取り組みと人々(全学共通)、薬物療法学Ⅲ、臨床薬物動態学、遺伝子診断学、病院実務実習(薬学部)、薬物治療学特論(大学院)


主要研究テーマ

・薬物応答性・副作用発現に関わる因子の探索
・診断に有用なバイオマーカーの探索


所属学会

日本薬学会
日本医療薬学会
日本癌学会
日本生物学的精神医学会
医薬品相互作用研究会


主な経歴

1997年4月~2000年3月 秋田大学医学部附属病院薬剤部薬剤師
2000年4月~2002年3月 東北大学医学部附属病院薬剤部薬剤師(人事交流による)
2002年4月~2008年3月 秋田大学医学部附属病院薬剤部主任
2008年4月~2016年9月 静岡県立大学講師
2016年10月~ 静岡県立大学准教授


受賞歴

2003年 日本薬学会東北支部 奨励賞
2006年 秋田県病院薬剤師会 臨床薬学賞


主な社会活動

 


主要研究業績

2008年以降
○原著論文
・Tsuji D, Yokoi M, Suzuki K, Daimon T, Nakao M, Ayuhara H, Kogure Y, Shibata K, Hayashi T, Hirai K, Inoue K, Hama T, Takeda K, Nishio M, Itoh K. Influence of ABCB1 and ABCG2 polymorphisms on the antiemetic efficacy in patients with cancer receiving cisplatin-based chemotherapy: a TRIPLE pharmacogenomics study. Pharmacogenomics J. in press.
・幕田龍,辻大樹,金容壱,山本圭祐,大嶽亜季,横井茉里,中森春美,井上和幸,平井啓太,中道秀徳,塩川 満,伊藤邦彦. ドキソルビシン/シクロホスファミド併用療法施行乳がん患者における化学療法誘発性悪心・嘔吐に対するアプレピタントの効果の検討. 医療薬学. 43,1-8 (2017)
・Tsuji D, Ikeda M, Yamamoto K, Nakamori H, Kim Y, Kawasaki Y, Otaki A, Yokoi M, Inoue K, Hirai K, Nakamichi H, Tokou U, Shiokawa M, Itoh K. Drug-related genetic polymorphisms affecting severe chemotherapy-induced neutropenia in breast cancer patients: A hospital-based observational study. Medicine. 95, e5151 (2016)
・Hirai K, Ishii H, Shimoshikiryo T, Shimomura T, Tsuji D, Inoue K, Kadoiri T, Itoh K. Augmented renal clearance in patients with febrile neutropenia is associated with increased risk for subtherapeutic concentrations of vancomycin. Ther Drug Monit. 38, 706-710 (2016)
・Hirai K, Shimomura T, Moriwaki H, Ishii H, Shimoshikiryo T, Tsuji D, Inoue K, Kadoiri T, Itoh K. Risk factors for hypernatremia in patients with short- and long-term tolvaptan treatment. Eur J Clin Pharmacol. 72, 1177-1183 (2016)
・Inoue K, Murofushi T, Nagaoka K, Ando N, Hakamata Y, Suzuki A, Umemura A, Yoshida Y, Hirai K, Tsuji D, Itoh K. Influence of genetic polymorphisms and concomitant anxiolytic doses on antidepressant maintenance doses in Japanese patients with depression. Bio Pharm Bull. 39, 1508-1513 (2016)
・Inoue K, Yamamoto Y, Suzuki E, Takahashi T, Umemura A, Takahashi Y, Imai K, Inoue Y, Hirai K, Tsuji D, Itoh K. Factors that influence the pharmacokinetics of lamotrigine in Japanese patients with epilepsy. Eur J Clin Pharmacol. 72, 555-562 (2016)
・Inoue K, Takahashi T, Yamamoto Y, Suzuki E, Takahashi Y, Imai K, Inoue Y, Hirai K, Tsuji D, Itoh K. Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy. Seizure. 33, 76-80 (2015)
・Tazoe Y, Hayashi H, Tsuboi S, Shioura T, Matsuyama T, Yamada H, Hirai K, Tsuji D, Inoue K, Sugiyama T, Itoh K. Reduced folate carrier 1 gene expression levels are correlated with methotrexate efficacy in Japanese patients with rheumatoid arthritis. Drug Metab Pharmacokinet. 30, 227-230 (2015)
・Hirai K, Yamada Y, Hayashi H, Tanaka M, Izumiya K, Suzuki M, Yoshizawa M, Moriwaki H, Akimoto T, Tsuji D, Inoue K, Itoh K. Plasma vitamin K concentrations depend on CYP4F2 polymorphism and influence on anticoagulation in Japanese patients with warfarin therapy. Thromb Res. 135, 861-866 (2015)
・Ikeda M, Tsuji D, Yamamoto K, Kim YI, Daimon T, Iwabe Y, Hatori M, Makuta R, Hayashi H, Inoue K, Nakamichi H, Shiokawa M, Itoh K. Relationship between ABCB1 gene polymorphisms and severe neutropenia in patients with breast cancer treated with doxorubicin/cyclophosphamide chemotherapy. Drug Metab Pharmacokinet. 30, 149-153 (2015)
・Inoue K, Suzuki E, Takahashi T, Yamamoto Y, Yazawa R, Takahashi Y, Imai K, Miyakawa K, Inoue Y, Tsuji D, Hayashi H, Itoh K. 4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy. Epilepsy Res. 108, 1046-1051 (2014)
・Inoue K, Suzuki E, Yazawa R, Yamamoto Y, Takahashi T, Takahashi Y, Imai K, Koyama S, Inoue Y, Tsuji D, Hayashi H, Itoh K. Influence of uridine diphosphate glucuronosyltransferase 2B7 -161C>T polymorphism on the concentration of valproic acid in pediatric epilepsy patients. Ther Drug Monit. 36, 406-409 (2014)
・Saito M, Kondo M, Ohshima M, Deguchi K, Hayashi H, Inoue K, Tsuji D, Masuko T, Itoh K. Identification of anti-CD98 antibody mimotopes for inducing antibodies with antitumor activity by mimotope immunization. Cancer Sci. 105, 396-401 (2014)
・Takahashi H, Yoshida K, Higuchi H, Kamata M, Inoue K, Suzuki T, Ishigooka J. Bcl1 polymorphism of the glucocorticoid receptor gene and treatment response to milnacipran and fluvoxamine in Japanese patients with depression. Neuropsychobiology. 70, 173-180 (2014)
・羽鳥正浩,辻大樹,多久佳成,大門貴志,亀里真那,池田翠,幕田 龍,林秀樹,井上和幸,伊藤邦彦. ゲムシタビン施行切除不能膵がん患者における予後因子の検討. 医療薬学. 40, 734-741 (2014)
・Yamamoto Y, Takahashi Y, Imai K, Mishima N, Yazawa R, Inoue K, Itoh K, Kagawa Y, Inoue Y. Risk factors for hyperammonemia in pediatric patients with epilepsy. Epilepsia. 54, 983-989 (2013)
・Tsuji D, Kim YI, Nakamichi H, Daimon T, Suwa K, Iwabe Y, Hayashi H, Inoue K, Yoshida M, Itoh K. Association of ABCB1 polymorphisms with the antiemetic efficacy of granisetron plus dexamethasone in breast cancer patients. Drug Metab Pharmacokinet. 28, 299-304 (2013)
・Tsuji D, Kamezato M, Daimon T, Taku K, Hatori M, Ikeda M, Hayashi H, Inoue K, Eto T, Itoh K. Retrospective analysis of severe neutropenia in patients receiving concomitant administration of docetaxel and clarithromycin. Chemotherapy. 59, 407-413 (2013)
・Hayashi H, Tazoe Y, Tsuboi S, Horino M, Morishita M, Arai T, Ohshima M, Matsuyama T, Kosuge K, Yamada H, Tsuji D, Inoue K, Itoh K. A single nucleotide polymorphism of reduced folate carrier 1 predicts methotrexate efficacy in Japanese patients with rheumatoid arthritis. Drug Metab Pharmacokinet. 28, 164-168 (2013)
・Inoue K, Sonobe M, Kawamura Y, Etoh T, Takagi M, Matsumura T, Kikuyama M, Kimura M, Minami S, Utsuki H, Yamazaki T, Suzuki T, Tsuji D, Hayashi H, Itoh K. Polymorphisms of the UDP-glucuronosyl transferase 1A genes are associated with adverse events in cancer patients receiving irinotecan-based chemotherapy. Tohoku J Exp Med. 229, 107-114 (2013)
・Yamamoto Y, Takahashi Y, Suzuki E, Mishima N, Inoue K, Itoh K, Kagawa Y, Inoue Y. Risk factors for hyperammonemia associated with valproic acid therapy in adult epilepsy patients. Epilepsy Res. 101, 202-209 (2012)
・Inoue K, Ando N, Suzuki E, Hayashi H, Tsuji D, Itoh K. Genotype distributions and allele frequencies of possible major depressive disorder-associated single nucleotide polymorphisms, cyclic adenosine monophosphate response element binding protein 1 rs4675690 and Piccolo rs2522833, in a Japanese population. Biol Pharm Bull. 35, 265-268 (2012)
・Hayashi H, Tazoe Y, Horino M, Fujimaki-Katoh C, Tsuboi S, Matsuyama T, Kosuge K, Yamada H, Tsuji D, Inoue K, Itoh K. An artifact derived from a pseudogene led to the discovery of microRNA binding site polymorphism in the 3'-untranslated region of the human dihydrofolate reductase gene. Drug Metab Pharmacokinet. 27, 263-267 (2012)
・Ohshima M, Inoue K, Hayashi H, Tsuji D, Mizugaki M, Itoh K. Generation of AcGFP fusion with single-chain Fv selected from a phage display library constructed from mice hyperimmunized against 5-methyl 2'-deoxycytidine. Protein Eng Des Sel. 23, 881-888 (2010)
・坂和園子, 林 秀樹, 吉澤美沙, 堀野雅人, 森脇秀明, 秋本剛秀, 土井 修, 井上和幸, 辻 大樹, 河原崎貴伯, 伊藤邦彦. ワルファリン服用患者における出血リスクに対するプロトンポンプ阻害薬併用の影響. 日本病院薬剤師会雑誌. 46, 535-538 (2010)
・Hayashi H, Horino M, Morishita M, Tazoe Y, Tsuboi S, Matsuyama T, Kosuge K, Yamada H, Tsuji D, Inoue K, Itoh K. Dihydrofolate reductase gene intronic 19-bp deletion polymorphisms in a Japanese population. Drug Metab Pharmacokinet. 25, 516-518 (2010)
・Ohshima M, Tadakuma T, Hayashi H, Inoue K, Itoh K. Generation of a recombinant single-chain variable fragment (scFv) targeting 5-methyl-2'-deoxycytidine. J Biochem. 147, 135-141 (2010)
・Miura M, Inoue K, Kagaya H, Saito M, Habuchi T, Satoh S. Inter-individual difference determinant of prednisolone pharmacokinetics for Japanese renal transplant recipients in the maintenance stage. Xenobiotica. 39, 939-945 (2009)
・Yoshizawa M, Hayashi H, Tashiro Y, Sakawa S, Moriwaki H, Akimoto T, Doi O, Kimura M, Kawarasaki Y, Inoue K, Itoh K. Effect of VKORC1-1639 G>A polymorphism, body weight, age, and serum albumin alterations on warfarin response in Japanese patients. Thromb Res. 124, 161-166 (2009)
・Satoh S, Saito M, Inoue T, Kagaya H, Miura M, Inoue K, Komatsuda A, Tsuchiya N, Suzuki T, Habuchi T. CYP3A5*1 allele associated with tacrolimus trough concentrations but not subclinical acute rejection or chronic allograft nephropathy in Japanese renal transplant recipients. Eur J Clin Pharmacol. 65, 473-481 (2009)
・Fujiyama N, Miura M, Satoh S, Inoue K, Kagaya H, Saito M, Habuchi T, Suzuki T. Influence of carboxylesterase 2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Xenobiotica. 39, 407-414 (2009)
・林 秀樹, 神戸宏憲, 吉川俊博, 大門貴志, 鍋田いづみ, 木村 緑, 山田 浩, 浮島美之, 井上和幸, 河原崎貴伯, 伊藤邦彦. がん化学療法における携帯型ディスポーザブル注入ポンプの流速変動因子の解析. 日本病院薬剤師会雑誌. 45, 821-824 (2009)
・Fujimaki C, Hayashi H, Tsuboi S, Matsuyama T, Kosuge K, Yamada H, Inoue K, Itoh K. Plasma total homocysteine level and methylenetetrahydrofolate reductase 677C>T genetic polymorphism in Japanese patients with rheumatoid arthritis. Biomarkers. 14, 49-54 (2009)
・Itoh K, Ohshima M, Sonobe M, Saito M, Yoshida A, Hayashi H, Inoue K, Masuko T. Antibody epitope peptides as potential inducers of IgG antibodies against CD98 oncoprotein. Cancer Sci. 100, 126-131 (2009)
・Miura M, Satoh S, Inoue K, Saito M, Habuchi T, Suzuki T. Telmisartan pharmacokinetics in Japanese renal transplant recipients. Clin Chim Acta. 399, 83-87 (2009)
・Miura M, Satoh S, Inoue K, Kagaya H, Saito M, Inoue T, Habuchi T, Suzuki T. Influence of CYP3A5, ABCB1 and NR1I2 polymorphisms on prednisolone pharmacokinetics in renal transplant recipients. Steroids. 73, 1052-1059 (2008)
・Miura M, Kagaya H, Satoh S, Inoue K, Saito M, Habuchi T, Suzuki T. Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients. Ther Drug Monit. 30, 559-564 (2008)
・Saito M, Satoh S, Kagaya H, Tsuruta H, Obara T, Kumazawa T, Inoue T, Inoue K, Miura M, Yuasa T, Komatsuda A, Tsuchiya N, Habuchi T. Thrombotic microangiopathy developing in early stage after renal transplantation with a high trough level of tacrolimus. Clin Exp Nephrol. 12, 312-315 (2008)
・Satoh S, Kagaya H, Saito M, Inoue T, Miura M, Inoue K, Numakura K, Tsuchiya N, Tada H, Suzuki T, Habuchi T. Lack of tacrolimus circadian pharmacokinetics and CYP3A5 pharmacogenetics in the early and maintenance stages in Japanese renal transplant recipients. Br J Clin Pharmacol. 66, 207-214 (2008)
・Kagaya H, Miura M, Satoh S, Inoue K, Saito M, Inoue T, Habuchi T, Suzuki T. No pharmacokinetic interactions between mycophenolic acid and tacrolimus in renal transplant recipients. J Clin Pharm Ther. 33, 193-201 (2008)
・Yoshida K, Higuchi H, Takahashi H, Kamata M, Sato K, Inoue K, Suzuki T, Itoh K, Ozaki N. Influence of the tyrosine hydroxylase val81met polymorphism and catechol-O-methyltransferase val158met polymorphism on the antidepressant effect of milnacipran. Hum Psychopharmacol. 23, 121-128 (2008)
・Miura M, Satoh S, Inoue K, Kagaya H, Saito M, Suzuki T, Habuchi T. Influence of lansoprazole and rabeprazole on mycophenolic acid pharmacokinetics one year after renal transplantation. Ther Drug Monit. 30, 46-51 (2008)

○著書
・井上和幸, 辻大樹, 平井啓太, 宮嵜靖則, 内野智信, 川崎洋平, 山田浩, 賀川義之, 伊藤邦彦. 連載・実務実習をより良くするために (18) 静岡県立大学薬学部・薬学教育研究センターの役割. 医薬ジャーナル. 52, 129-131 (2016)
・井上和幸. 個別化医療を目指した臨床薬物動態学 1巻 第2章 薬理遺伝学. 猪爪信夫, 栄田敏之, 伊藤邦彦 編集. 廣川書店. pp.29-62 (2016)
・井上和幸. 個別化医療を目指した臨床薬物動態学 2巻 第5章 治療薬物モニタリング各論 免疫抑制剤. 猪爪信夫, 栄田敏之, 伊藤邦彦 編集, 廣川書店. pp.286-301 (2016)
・井上和幸, 伊藤邦彦. 薬効モニタリングの実践-13 排尿障害. 薬局. 108-112 (2011)


教育・研究に対する考え方

教育:問題発見・自己解決能力を持つ薬剤師を育成したい。
研究:患者個々に見合った最適な薬物療法を提供できるよう研究を行っていきたい。


研究シーズ集に関するキーワード

個別化医療、遺伝子多型、バイオマーカー、薬物応答、副作用、精神神経疾患


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