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静岡県立大学教員データベース


教員情報詳細


写真:岩尾 康範

氏名
岩尾 康範(IWAO Yasunori)
出生年月
1978年5月
所属・職名
薬学部薬学科(創剤科学分野) 准教授
薬学研究院(創剤工学教室) 准教授(兼務)
電話番号
054-264-5612
部屋番号
薬学部棟6117号室
Eメールアドレス
yasuiwao@u-shizuoka-ken.ac.jp
ホームページアドレス(URL)
http://w3pharm.u-shizuoka-ken.ac.jp/pharmeng/
研究シーズ集
http://www.u-shizuoka-ken.ac.jp/media/seeds2017_01_029.pdf

学歴

2001年3月 熊本大学薬学部薬科学科卒業
2003年3月 熊本大学大学院薬学研究科博士前期課程修了
2006年3月 熊本大学大学院薬学教育部博士後期課程修了

学位

博士(薬学)(熊本大学・2006年)

専門分野

製剤設計,粉体工学,DDS,薬物動態学

担当科目

創剤工学、製剤学、物理化学Ⅲ、創剤工学特論、医療系薬学実習、医用工学実習

主要研究テーマ

  • 固形製剤のための機能性製剤材料の探索と評価
  • 多変量解析を用いた流動層造粒法、遠心転動造粒法の製造条件の最適化
  • 保存安定性の高い脂質ナノ粒子の調製と評価
  • 新規口腔内崩壊茶錠の設計と評価
  • タンパク質徐放性製剤の設計と評価
  • ポリフェノール含有固体分散体の設計と評価

所属学会

日本薬学会
日本動態学会
日本薬剤学会
製剤機械技術研究会
粉体工学会
化学工学会(静岡化学工学懇話会役員)
日本DDS学会

主な経歴

2006年4月 熊本大学大学院医学薬学研究部 教務補佐員
2006年10月 財団法人 日本公定書協会 リサーチ・レジデント
2007年4月 財団法人 ヒューマンサイエンス振興財団 リサーチ・レジデント
2008年4月 静岡県立大学薬学部助教
2014年4月 静岡県立大学薬学部講師
2016年4月 静岡県立大学薬学部准教授

受賞歴

  1. 第1回 製剤機械技術学会 仲井賞若手研究者奨励賞(平成30年3月)
  2. 第4回 静岡県立大学学長表彰(平成29年12月)
  3. Elsevier Outstanding Reviewer Award 2016 for Advanced Powder Technology(平成28年9月)
  4. 一般財団法人 新製剤技術とエンジニアリング振興基金 第三回パーティクルデザイン賞 (平成28年7月)
  5. 日本薬剤学会 2016年度旭化成創剤研究奨励賞 (平成28年5月)
  6. 第1回 静岡県立大学学長表彰(平成27年3月)
  7. Elsevier Outstanding Reviewer Award 2014 for Advanced Powder Technology(平成26年7月)
  8. 日本薬学会東海支部奨励賞(平成26年7月)
  9. The APSTJ Global Education Seminar Presentation Award 2012(平成24年10月)
  10. JSPS Core-to-Core Young Investigator Award 2007(平成19年7月)
  11. The Nagai foundation Tokyo Graduate student scholarship 2003(平成15年5月)

主な社会活動

2018年5月 日本薬剤学会第33年会・実行委員
2018年4月 日本薬学会 会誌編集委員 (-2020年3月)
2018年1月 日本薬剤学会 代議員
2016年10月- 製剤機械技術学会 会誌編集員委員
2016年10月- 日本薬剤学会 物性FG執行委員
2016年7月 第32回日本DDS学会学術集会・実行委員
2014年- Editorial Board of Journal of Pharmaceutical Sciences
2014年4月- 日本薬学会ファルマシア・トピックス小委員 (-2016年3月)
2013年- Editorial Board of BioMed Research International
2010年4月- 静岡化学工学懇話会・幹事

主要研究業績

(過去5年間)
  1. Asada T, Nishikawa M, Ochiai Y, Noguchi S, Kimura S, Iwao Y, Itai S. Mechanism of the formation of hollow spherical granules using a high shear granulator. European Journal of Pharmaceutical Sciences, (2018) in press. (IF=3.87)
  2. Asada T, Yoshihara N, Ochiai Y, Kimura S, Iwao Y, Itai S. Poorly water-soluble drug formulated as sustained release hollow granules with high viscosity water-soluble polymer by fluidized bed rotor granulator. International Journal of Pharmaceutics, (2018) in press. (IF=4.22)
  3. Otsuka T, Kuroiwa Y, Sato K, Yamashita K, Hakomori T, Kimura SI, Iwao Y, Itai S. Use of mixer torque rheometer to clarify the relationship between the kneading states of wet mass and the dissolution of final product in high shear granulation. Chemical & Pharmaceutical Bulletin, (2018) in press. (IF=1.29)
  4. Sakai T, Hirai D, Kimura S, Iwao Y, Itai S. Effects of tablet formulation and subsequent film coating on the supersaturated dissolution behavior of amorphous solid dispersions. International Journal of Pharmaceutics, (2018) in press. (IF=4.22)
  5. Iwao Y#, Tomiguchi I, Domura A, Mantaira Y, Minami A, Suzuki T, IkawaT, Kimura S, Itai S. Inflamed site-specific drug delivery system based on the interaction of human serum albumin nanoparticles with myeloperoxidase in a murine model of experimental colitis. European Journal of Pharmaceutics and Biopharmaceutics, 125, 141-147, (2018). (IF=4.51) (#: Corresponding author)
  6. Yoshino H, Hara Y, Dohi M, Yamashita K, Hokomori T, Kimura S, Iwao Y, Itai S. A scale-up approach for film coating process based on surface roughness as the critical quality attribute. AAPS PharmSciTech, doi: 10.1208/s12249-017-0940-9, (2018). (IF=2.45).
  7. Oishi S, Kimura S, Noguchi S, Kondo M, Kondo Y, Shimokawa Y, Iwao Y#, Itai S#. New scale-down methodology from commercial to lab scale to optimize plant-derived soft gel capsule formulations on a commercial scale. International Journal of Pharmaceutics, 535, 371-378 (2018). (IF=4.22) (#: Equal corresponding author)
  8. Oshiro S, Ishima Y, Maeda H, Honda N, Bi J, Kinoshita R, Ikeda M, Iwao Y, Imafuku T, Nishida K, Miyamura S, Watanabe H, Otagiri M, Maruyama T. Dual therapeutic effects of an albumin-based nitric oxide donor on two experimental models of chronic kidney disease. Journal of Pharmaceutical Sciences, 107, 848-855 (2018). (IF=2.86)
  9. Fukami T, Tanida S, Koide T, Gato K, Ono M, Iwao Y, Higashi K, Ikeda Y, Yonemochi E. A Proposal for Regulation of Pharmaceutical Cocrystals. Pharmaceutical and Medical Device Regulatory Science, 48 (12) (2017). (Japanese). (IF=not available)
  10. Matsumoto K, Kimura S, Iwao Y, Itai S. Applicability of low-melting-point microcrystalline wax to develop temperature-sensitive formulations. International Journal of Pharmaceutics, 532, 528-536 (2017). (IF=4.22)
  11. Matsushita S, Nishi K, Iwao Y, Ishima Y, Watanabe H, Taguchi K, Yamasaki K, Maruyama T, Otagiri M. Recombinant Human Serum Albumin Containing 3 copies of Domain I, has Significant In Vitro Antioxidative Capacity Compared to the Wild-type. Biological and Pharmaceutical Bulletin, 40, 1813-1817 (2017). (IF=1.87)
  12. Kondo H, Toyota H, Kamiya T, Yamashita K, Hakomori T, Imoto J,, Kimura S, Iwao Y, Itai S. Application of external lubrication to maintain the adhesion properties of a film layer for coating tablets. Chemical & Pharmaceutical Bulletin, 65, 848-853 (2017) (IF=1.29).
  13. Unno K, Yamada H, Iguchi K, Ishida H, Iwao Y, Morita A, Nakamura Y. Anti-stress effect of green tea with lowered caffeine on human: A Pilot Study. Biological and Pharmaceutical Bulletin, 40, 902-909 (2017). (IF=1.87)
  14. Shiino K, Fujinami Y, Kimura S, Iwao Y, Noguchi S, Itai S. Melt adsorption as a manufacturing method for fine particles of wax matrices without any aggromalates. Chemical & Pharmaceutical Bulletin, 65, 726-731 (2017). (IF=1.29) (Highlighted Paper selected by Editor-in-Chief).
  15. Asada T, Kobiki M, Ochiai Y, Iwao Y, Itai S. An innovative method for the preparation of high API-loaded hollow spherical granules for use in controlled-release formulation. International Journal of Pharmaceutics, 523, 167-175 (2017). (IF=4.22)
  16. Sakurai Y, Mise R, Kimura S, Noguchi S, Iwao Y#, Itai S#. Novel method for improving the water dispersibility and flowability of fine green tea powder using a fluidized bed granulator. Journal of Food Engineering, 206, 118-124 (2017). (#: Equal corresponding author) (IF= 3.59)
  17. Banerjee A*, Ibsen K*, Iwao Y*, Zakrewsky M, Mitragotri S. Transdermal Protein Delivery Using Choline and Geranate Deep Eutectic Solvent. Advanced Healthcare Materials, doi: 10.1002/adhm.201601411, (2017). (*: Equal contribution) (IF= 5.45)
  18. Hirai D, Iwao Y, Kimura S, Noguchi S, Itai S. Mathematical model to analyze the dissolution behavior of metastable crystals or amorphous drug accompanied with a solid-liquid interface reaction. International Journal of Pharmaceutics, 522, 58-65 (2017). (IF=4.22)
  19. Matsuzaki N, Yamamoto Y, Murayama D, Katakawa Y, Mimura H, Kimura S, Iwao Y, Itai S. Evaluation of maltose-induced chemical degradation at the interface of bilayer tablets. Chemical & Pharmaceutical Bulletin, 65, 478-486 (2017). (IF=1.29)
  20. Inukai K, Takiyama K, Iwao Y, Noguchi S, Itai S. Effect of gel formation on the dissolution behavior of clarithromycin tablets. International Journal of Pharmaceutics, 521, 33-39 (2017). (IF=4.22)
  21. Ali MA, Kataoka N, Ranneh AH, Iwao Y, Noguchi S, Oka T, Itai S. Enhancing the Solubility and Oral Bioavailability of Poorly Water-Soluble Drugs using Monoolein Cubosomes. Chemical & Pharmaceutical Bulletin, 65, 42-48 (2017). (IF=1.29)
  22. Terada T, Ohtsubo T, Iwao Y, Noguchi S, Itai S. Evaluation of the thermosensitive release properties of microspheres containing an agrochemical compound. Chemical & Pharmaceutical Bulletin, 65, 49-55 (2017). (IF=1.29) (Highlighted Paper selected by Editor-in-Chief)
  23. Ranneh AH, Iwao Y, Noguchi S, Oka T, Itai S. Use of charged additives enhances the solubility and stability of the water-insoluble anticancer drug SN38 in liquid crystalline phase nanoparticles, cubosomes. International Journal of Pharmaceutics, 515, 501-505 (2016). (IF=4.22)
  24. Ali MA, Noguchi S, Watanabe M, Iwao Y, Itai S. Structure of anti-tumor drug 7-ethyl-10-hydroxycamptothecin monohydrate and its solid state hydrolysis mechanism on heating. Acta Crystallographica Section C, 72, 743-747 (2016).(IF=4.10)
  25. Watanabe M, Mizoguchi M, Aoki H, Iwao Y, Noguchi S, Itai S. Saturated fatty acids and fatty acid esters promotes the polymorphic transition of clarithromycin metastable form I crystal. International Journal of Pharmaceutics, 512, 108-117 (2016). (IF=4.22)
  26. Ito Y, Maeda A, Kondo H, Iwao Y, Noguchi S, Itai S. Application of water-insoluble polymers to orally disintegrating tablets treated by high-pressure carbon dioxide gas. International Journal of Pharmaceutics, 511, 10-22 (2016). (IF=4.22)
  27. Tanaka H, Iwao Y#, Izumikawa M, Sano S, Ishida H, Noguchi S, Itai S. Preparation of orally disintegrating tablets containing powdered tea leaves with enriched levels of bioactive compounds by means of microwave irradiation technique. Chemical & Pharmaceutical Bulletin, 64, 1288-1297 (2016). (#: Corresponding author) (IF=1.29)
  28. Terada T, Tagami M, Ohtsubo T, Iwao Y, Noguchi S, Itai S. Sustained-release microsphere formulation containing an agrochemical by polyurethane polymerization during an agitation granulation process. International Journal of Pharmaceutics, 509, 328-337 (2016). (IF=4.22)
  29. Ali MA, Iwao Y, Noguchi S, Oka T, Itai S. Preparation and Characterizations of SN-38 Encapsulated Cubosomes Containing α-Monoglyceride Additives. Chemical & Pharmaceutical Bulletin, 64, 577-584 (2016). (IF=1.29)
  30. Yoshino H, Yamashita K, Iwao Y, Noguchi S, Itai S. Quantitative appearance inspection for film coated tablets. Chemical & Pharmaceutical Bulletin, 64, 1226-1229 (2016). (IF=1.29)
  31. Kragh-Hansen U, Minchiotti L, Coletta A, Bienk K, Galliano M, Schiøtt B, Iwao Y, Ishima Y, Otagiri M. Mutants and molecular dockings reveal that the primary L-thyroxine binding site in human serum albumin is not the one which can cause familial dysalbuminemic hyperthyroxinemia. Biochimica et Biophysica Acta, 1860, 648-660 (2016). (IF=4.83)
  32. Noguchi S, Atsumi H, Iwao Y, Kan T, Itai S. Nobiletin: a citrus flavonoid displaying potent physiological activity. Acta Crystallographica Section C, 72, 124-127 (2016). (IF=4.10)
  33. Kamiya T, Kondo H, Hiroma H, Yamashita K, Sako K, Iwao Y, Noguchi S, Itai S. Impact of process parameters on Mg-St content and tablet surface wettability in the external lubrication method for a rotary tablet press. Advanced Powder Technology, 27, 193-198 (2016). (IF=2.66)
  34. Mise R, Iwao Y, Kimura S, Osugi Y, Noguchi S, Itai S. Investigation of physicochemical drug properties to prepare fine globular granules composed of only drug substance in fluidized bed rotor granulation. Chemical & Pharmaceutical Bulletin, 63, 1070-1075 (2015). (IF=1.29)
  35. Kajihara R, Noguchi S, Iwao Y, Yasuda Y, Segawa M, Itai S. Structural investigation of spherical hollow excipient Mannit Q by X-ray microtomography. International Journal of Pharmaceutics, 495, 140-143 (2015). (IF=4.22)
  36. Nozawa K, Iwao Y, Noguchi S, Itai S. Effect of surfactants or a water soluble polymer on the crystal transition of clarithromycin during a wet granulation process. International Journal of Pharmaceutics, 495, 204-217 (2015). (IF=4.22)
  37. Yamada K*, Iwao Y*, Bani-Jaber A, Noguchi S, Itai S. Preparation and evaluation of newly developed chitosan salt coating dispersions for colon delivery without requiring overcoating. Chemical & Pharmaceutical Bulletin, 63, 799-806 (2015). (*: Equal contribution) (IF=1.29)
  38. Iwao Y. Efficient pharmaceutical formulation designs and their development using mathematical and statistical analysis. Yakugaku Zasshi, 135, 1129-1134 (2015). (Review article) (IF=0.33)
  39. Funakoshi Y, Iwao Y, Noguchi S, Itai S. Effect of alkyl chain length and unsaturation of the phospholipid on the physicochemical properties of lipid nanoparticles. Chemical & Pharmaceutical Bulletin, 63, 731-736 (2015). (IF=1.29)
  40. Fujiki S, Watanabe N, Iwao Y, Noguchi S, Mizoguchi M, Iwamura, T, Itai S. Suppressed release of clarithromycin from tablets by crystalline phase transition of metastable polymorph form I. Journal of Pharmaceutical Sciences, 104, 2641-2644 (2015). (IF=2.86)
  41. Aoki H*, Iwao Y*, Mizoguchi M, Noguchi S, Itai S. Clarithromycin highly-loaded gastro-floating fine granules prepared by high-shear melt granulation can enhance the efficacy of Helicobacter pylori eradication. European Journal of Pharmaceutics and Biopharmaceutics, 92, 22-27 (2015). (*: Equal contribution) (IF=4.51)
  42. Iwao Y, Banno N, Kakinuma M, Noguchi S, Itai S. Study of proper use and storage stability of surfactant in dissolution test. Pharmaceutical and Medical Device Regulatory Science, 46, 171-179 (2015) (Japanese). (IF=not available)
  43. Bani-Jaber A, Kobayashi A, Yamada K, Haj-Ali DN, Uchimoto T, Iwao Y#, Noguchi S, Itai S. A newly developed lubricant, chitosan laurate, in the manufacture of acetaminophen tablets. International Journal of Pharmaceutics, 483, 49-56 (2015). (#: Corresponding author) (IF=4.22)
  44. Kajihara R, Noguchi S, Iwao Y, Suzuki Y, Terada Y, Uesugi K, Itai S. Structural changes of polymer-coated microgranules and excipients on tableting investigated by microtomography using synchrotron X-ray radiation. International Journal of Pharmaceutics, 481, 132-139 (2015). (IF=4.22)
  45. Aoki H, Iwao Y, Uchimoto T, Noguchi S, Kajihara R, Ishida M, Takahashi K, Terada Y, Suzuki Y, Itai S. Fine granules showing sustained drug release prepared by high-shear melt granulation using triglycerin full behenate and milled microcrystalline cellulose. International Journal of Pharmaceutics, 478, 530-539 (2015). (IF=4.22)
  46. Iwao Y, Kimura S, Ishida M, Mise R, Yamada M, Namiki N, Noguchi S, Itai S. Preparation and evaluation of highly drug-loaded fine globular granules using a multi-functional rotor processor. Chemical & Pharmaceutical Bulletin, 63, 95-101 (2015). (IF=1.29)
  47. Barman RK, Iwao Y, Noguchi S, Wahed MII, Itai S. Improving flow property of nifedipine loaded solid-lipid nanoparticles by means of silica for oral solid dosage form. Pharmacology & Pharmacy, 5, 1119-1129 (2014). (IF=not available)
  48. Sano S, Iwao Y, Kimura S, Noguchi S, Itai S. Impact of active ingredients on the swelling properties of orally disintegrating tablets prepared by microwave treatment. International Journal of Pharmaceutics, 468, 234-242 (2014). (IF=4.22)
  49. Barman RK, Iwao Y, Islam Md, Funakoshi Y, Noguchi S, Wahed MII, Itai S. In vivo pharmacokinetic and hemocompatible evaluation of lyophilization induced nifedipine solid-lipid nanoparticle. Pharmacology & Pharmacy, 5, 455-461 (2014). (IF=not available)
  50. Barman RK, Iwao Y, Funakoshi Y, Ranne AH, Noguchi S, Wahed MII, Itai S. Development of highly stable nifedipine solid-lipid nanoparticles. Chemical & Pharmaceutical Bulletin, 62, 399-406 (2014). (IF=1.29)
  51. Yamanaka M, Yokota S, Iwao Y, Noguchi S, Itai, S. Development and evaluation of a tacrolimus cream formulation using a binary solvent system. International Journal of Pharmaceutics, 464, 19-26 (2014). (IF=4.22)
  52. Kimura S, Iwao Y, Ishida M, Noguchi S, Itai S Uchida S, Yamada M, Namiki N. Evaluation of the physicochemical properties of fine globular granules prepared by a multi-functional rotor processor. Chemical & Pharmaceutical Bulletin, 62, 309-315 (2014). (IF=1.29)
  53. Noguchi S, Takiyama K, Fujiki S, Iwao Y, Miura K, Itai S. Polymorphic transformation of antibiotic clarithromycin under acidic condition. Journal of Pharmaceutical Sciences, 103, 580-586 (2014). (IF=2.86)
  54. Yamada N, Mise R, Ishida M, Iwao Y, Noguchi S, Itai S. Effects of the centrifugal coating and centrifugal fluidized bed coating methods on the physicochemical properties of sustained-release microparticles using a multi-functional rotor processor. Advanced Powder Technology, 25, 430-435 (2014). (IF=2.66)

教育・研究に対する考え方

日々の授業・実習・研究を通して、常に情熱と誠意をもって創薬及び薬剤師教育にあたり、基礎から臨床まで多様な分野で活躍できる人材の育成に努めたい。

研究シーズ集に関するキーワード

難溶性化合物の可溶化,消化管吸収促進,バイオアベイラビリティ

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