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静岡県立大学教員データベース


教員情報詳細


写真:賀川 義之

氏名
賀川 義之(KAGAWA Yoshiyuki)
所属・職名
薬学部薬学科(臨床薬剤学分野) 教授
薬学研究院(臨床薬剤学教室) 教授(兼務)
薬学部長
Eメールアドレス
kagaway@u-shizuoka-ken.ac.jp
ホームページアドレス(URL)
http://w3pharm.u-shizuoka-ken.ac.jp/rinyaku/
研究シーズ集
http://www.u-shizuoka-ken.ac.jp/media/seeds2017_01_032.pdf

学歴

静岡薬科大学薬学部製薬学科卒業
静岡薬科大学大学院薬学研究科修士課程修了

学位

博士(医学)(三重大学・1995年)

専門分野

臨床薬剤学、臨床薬物動態学

担当科目

医薬品安全性学、医薬品情報学Ⅰ、調剤学、薬学と社会、病院・薬局実習、くすりと医療の歩み、特別実習、臨床薬剤学特論、薬物治療学特論、治験・臨床開発応用特論、臨床薬学実習、講座特別実験I、保健医療福祉論

主要研究テーマ

  • 抗がん薬、抗てんかん薬、認知症治療薬などの臨床薬物動態を指標とした治療効果・有害事象発現様式の解明

所属学会

日本薬学会(理事)
日本医療薬学会(代議員、指導薬剤師、認定薬剤師)
日本薬理学会(学術評議員)、日本臨床薬理学会(特別指導薬剤師)
日本医薬品情報学会
日本薬学教育学会
日本医学教育学会
ジェネリック医薬品学会
日本TDM学会
日本DDS学会
日本薬剤学会
日本がん学会
日本リウマチ学会
American Society of Healthcare-System Pharmacists (ASHP)

主な経歴

1985年4月 三重大学医学部附属病院(文部技官)
1995年9月 同 薬剤主任
1996年4月 同 副薬剤部長
2000年10月 ミシシッピ大学薬学部 Visiting Scholar(- 2001年3月)
2005年4月  静岡県立大学薬学部教授(大学院兼務)

主な社会活動

Pharmaceutical Care Forum三重 代表運営委員(2000−2005年)
日本病院薬剤師会 代議員(2001−2004年)
三重県病院薬剤師会 副会長(2001−2005年)
日本薬学会 東海支部 幹事(2006−2007年)、医療薬学部会 世話人(2012-2013年)、代議員(2006−2007年、2010−2016年)、教育委員(2013−2015年)、理事(2017年-)、薬学雑誌編集委員(2017年ー)、薬剤雑誌編集委員長(2018年-)、Biological & Pharmaceutical Bulletin及びChemical & Pharmaceutical Bulletin誌 Section Editor-In-Chief(2017年-)
日本医療薬学会 代議員、医療薬学誌編集委員(2008−2015年)
薬学教育協議会 病態・薬物治療関連教科教員会議世話人(2012年−)
静岡ファルマバレー中央倫理審査委員会専門委員(2005年−)
東海地区病院・薬局実務実習調整機構委員(2005年−)
静岡県病院薬剤師会 常任理事(2007−2015年)
静岡県薬剤師会 常任理事(2010−2015年)、薬学・薬剤師教育協議会会長(2015年-)
Asian Association of Schools of Pharmacy, Board of Directors (2008−2011年)
静岡県後発医薬品検討会会長(2008−2009年)
静岡県後発医薬品の情報提供に関する協議会会長(2010−2011年)
静岡県災害薬事コーディネーター(2013−2017年)
静岡県薬事審議会会長(2016年−)

主要研究業績

  • Motoaki Ishikawa, Michiyasu Kawai, Toshio Maeda, Yoshiyuki Kagawa. Prediction of neutrophil reduction using plasma paclitaxel concentration after administration in patients with uterine, ovarian, or cervical cancers in an outpatient clinic. Cancer Chemother Pharmacol. 2018 Feb;81(2):399-411.
  • Yoshiaki Yamamoto, Naotaka Usui, Takuji Nishida, Miho Mori, Yukitoshi Takahashi, Katsumi Imai, Yoshiyuki Kagawa, Yushi Inoue. Influence of renal function on pharmacokinetics of antiepileptic drugs metabolized by CYP3A4 in a patient with renal impairment. Ther Drug Monit. 2018 Feb;40(1):144-147.
  • Masaki Tashiro, Takafumi Naito, Yoshiyuki Kagawa, Junichi Kawakami. Influence of cytochrome P450 genotype on the plasma disposition of prochlorperazine metabolites and their relationships with clinical responses in cancer patients. Ann Clin Biochem. 2017 Jan 1:4563217731432.
  • Yoshiaki Yamamoto, Naotaka Usui, Takuji Nishida, Yukitoshi Takahashi, Katsumi Imai, Yoshiyuki Kagawa, Yushi Inoue. Therapeutic Drug Monitoring for Perampanel in Japanese Epilepsy Patients: Influence of Concomitant Antiepileptic Drugs. Ther Drug Monit. 2017 Aug;39(4):446-449.
  • Tomonobu Uchino, Yasunori Miyazaki, Takuto Yamazaki, Yoshiyuki Kagawa. Immunogenicity of protein aggregates of a monoclonal antibody generated by forced shaking stress with siliconized and nonsiliconized syringes in BALB/c mice. J Pharm Pharmacol. 2017 Oct;69(10):1341-1351.
  • Tomonobu Uchino, Ichiro Hatta, Yasunori Miyazaki, Tomoya Onai, Takuto Yamazaki, Fuyoko Sugiura, Yoshiyuki Kagawa. Modulation mechanism of the stratum corneum structure during permeation of surfactant-based rigid and elastic vesicles. Int J Pharm. 2017 Apr 15;521(1-2):222-231.
  • Yasunori Miyazaki, Midori Mieno , Tomonobu Uchino , Yoshiyuki Kagawa. Influence of molecular weight and structure on diffusion rates and mechanisms of dextran polyelectrolyte complexes. Carbohydr Polym. 2017 Apr 15;162:42-48.
  • Yoshiaki Yamamoto, Yukitoshi Takahashi, Katsumi Imai, Yoshiyuki Kagawa, Yushi Inoue. Effect of CYP inducers/inhibitors on the topiramate concentration: Clinical value of therapeutic drug monitoring. Ther Drug Monit. 39(1):55-61, 2017.
  • Yasunori Miyazaki, Kozo Takayama, Tomonobu Uchino, Yoshiyuki Kagawa. Application of Response Surface Methodology to Estimate the Design Space of Pharmaceutical Diluents for Dispensing Powdered Formulations. Chem Pharm Bull. 64(12):1698-1706, 2016.
  • Yoshiaki Yamamoto, Kiyohito Terada, Yukitoshi Takahashi, Katsumi Imai, Yoshiyuki Kagawa, Yushi Inoue. Influence of antiepileptic drugs on serum lipid levels in adult epilepsy patients. Epilepsy Res. 127:101-106, 2016.
  • Kazuki Ide, Hiroshi Yamada, Yohei Kawasaki, Marika Noguchi, Mamoru Kitagawa, Tsuyoshi Chiba, Yoshiyuki Kagawa, Keizo Umegaki. Reporting of adverse events related to dietary supplements to a public health center by medical staff: a survey of clinics and pharmacies. Ther Clin Risk Manag. 12:1403-10, 2016.
  • Naohito Ide, Kasumi Arisawa, Kanami Ogura, Yoshiyuki Kagawa, Toshio Maeda. Age-Dependent Onset of Insulin Resistance in Insulin-Resistant Mice. Biol Pharm Bull. 38(12):1925-34, 2015.
  • Yasunori Miyazaki, Kaoru Miyawaki, Tomonobu Uchino, Yoshiyuki Kagawa. Dry Powder Coating using Planetary Centrifugal Mixer. J Pharm Pharm Sci. 18(3):460-73, 2015.
  • Tomonobu Uchino, Yasunori Miyazaki, Tomoyo Ohkawa, Takuto Yamazaki, Yoshitsugu Yanagihara, Takayuki Yoshimori, Mamoru Komatsu, Hiroshi Suzuki, Yoshiyuki Kagawa. Reconstitution of L-Asparaginase in Siliconized Syringes with Shaking and Headspace Air Induces Protein Aggregation. Chem Pharm Bull. 63(10):770-9, 2015.
  • Naohito Ide, Kasumi Arisawa, Kanami Ogura, Yoshiyuki Kagawa, Toshio Maeda. Age-Dependent Onset of Insulin Resistance in Insulin-Resistant Mice. Biol Pharm Bull. 38(12):1925-34, 2015.
  • Yoshiaki Yamamoto, Yukitoshi Takahashi, Katsumi Imai, Nobuyuki Mishima, Yoshiyuki Kagawa, Yushi Inoue. Changing incidence of hyperammonemia in Japan from 2006 to 2013: expansion of new antiepileptic drugs reduces the risk of hyperammonemia. Eur J Clin Pharmacol. 71(12), 1517-24, 2015.
  • Tomonobu Uchino Akiko Murata, Yasunori Miyazaki, Toshihiko Oka, Yoshiyuki Kagawa. Glyceryl Monooleyl Ether-Based Liquid Crystalline Nanoparticles as a Transdermal Delivery System of Flurbiprofen: Characterization and in Vitro Transport. Chem Pharm Bull. 63(5):334-40, 2015.
  • Yoshiaki Yamamoto, Yukitoshi Takahashi, Katsumi Imai, Hiroko Ikeda, Masaaki Takahashi, Masahiko Nakai, Yushi Inoue, Yoshiyuki Kagawa. Influence of uridine diphosphate glucuronosyltransferase inducers and inhibitors on the plasma lamotrigine concentration in pediatric patients with refractory epilepsy. Drug Metab Pharmacokinet. 30(3):214-220. 2015.
  • Takafumi Naito, Yasuaki Mino, Yuki Aoki, Kumi Hirano, Kumiko Shimoyama, Noriyoshi Ogawa, Yoshiyuki Kagawa, Junichi Kawakami. ABCB1 genetic variant and its associated tacrolimus pharmacokinetics affect renal function in patients with rheumatoid arthritis. Clin Chim Acta. 445:79-84, 2015.
  • Mikiko Tsukimoto, Rikiya Ohashi, Nao Torimoto, Yoko Togo, Takashi Suzuki, Toshio Maeda, Yoshiyuki Kagawa. Effects of the inhibition of intestinal P-glycoprotein on aliskiren pharmacokinetics in cynomolgus monkeys. Biopharm Drug Dispos. 36(1):15-33, 2015.
  • Yoshiaki Yamamoto, Yukitoshi Takahashi, Katsumi Imai, Kou Miyakawa, Hiroko Ikeda, Yuki Ueda, Tokito Yamaguchi, Hirosato Nasu, Hideyuki Ohtani, Hideo Shigematsu, Yoshiyuki Kagawa, Yushi Inoue. Individualized phenytoin therapy for pediatric Japanese epilepsy patients based on CYP2C9 and CYP2C19 genotypes. Ther Drug Monit. 37(2), 229-35, 2015.
  • Yukiko Katagiri, Yasunori Miyazaki, Tomonobu Uchino, Yoshiyuki Kagawa. Preparation of Goreisan Suppository and Pharmacokinetics of trans-Cinnamic Acid after Administration to Rabbits. Biol Pharm Bull. 37(11):1736-41, 2014.
  • Yoshiaki Yamamoto, Yukitoshi Takahashi, Katsumi Imai, Masaaki Takahashi, Masahiko Nakai, Yushi Inoue, Yoshiyuki Kagawa. Impact of cytochrome P450 inducers with or without inhibitors on the serum clobazam level in patients with antiepileptic polypharmacy. Eur J Clin Pharmacol. 70(10):1203-10, 2014.
  • Yasunori Miyazaki, Tomonobu Uchino, Yoshiyuki Kagawa. Evaluation of Degree of Blending Colored Diluents Using Color Difference Signal Method. Chem Pharm Bull. 62(5):488-90, 2014.
  • Yoshiaki Yamamoto, Yukitoshi Takahashi, Katsumi Imai, Yukiko Mogami, Kazumi Matsuda, Masahiko Nakai, Yoshiyuki Kagawa, Yushi Inoue. Interaction between sulthiame and clobazam: Sulthiame inhibits the metabolism of clobazam, possibly via an action on CYP2C19. Epilepsy Behav. May;34:124-6, 2014.
  • Yasunori Miyazaki, Kaoru Miyawaki, Tomonobu Uchino, Yoshiyuki Kagawa. Assessment of Blending Ratio of Powdered Medicine Mixtures by Image Analysis. Chem Pharm Bull. 62(4):322-7, 2014.
  • Tomonobu Uchino, Yuiko Matsumoto, Akiko Murata, Toshihiko Oka, Yasunori Miyazaki, Yoshiyuki Kagawa. Transdermal delivery of flurbiprofen from surfactant-based vesicles: Particle characterization and the effect of water on in vitro transport. Int J Pharm. 464(1-2):75-84, 2014.
  • Yasunori Miyazaki, Kaoru Miyawaki, Tomonobu Uchino, Yoshiyuki Kagawa. A Novel Blending Method for Dispensing Powdered Medicine. Chem Pharm Bull. 62(1):54-7, 2014.
  • Yoshiaki Yamamoto, Yukitoshi Takahashi, Katsumi Imai, Kou Miyakawa, Shigeko Nishimura, Risa Kasai, Hiroko Ikeda, Rumiko Takayama, Yukiko Mogami, Tokito Yamaguchi, Kiyohito Terada, Kazumi Matsuda, Yushi Inoue, Yoshiyuki Kagawa. Influence of CYP2C19 Polymorphism and Concomitant Antiepileptic Drugs on Serum Clobazam and N-Desmethyl Clobazam Concentrations in Patients With Epilepsy. Ther Drug Monit. 35(3):305-12, 2013.
  • Tomoyo Ohkawa, Tomonobu Uchino, Daisuke Sasakura, Yasunori Miyazaki, Yoshiyuki Kagawa. Particle Condition Change in Emulsion Admixture Evaluated by in Situ Flow Particle Imaging Analysis. Chem Pharm Bull. 61(3):333-9, 2013.
  • Masaki Tashiro, Takafumi Naito, Kazunori Ohnishi, Yoshiyuki Kagawa, Junichi Kawakami. Impact of genetic and non-genetic factors on clinical responses to prochlorperazine in oxycodone-treated cancer patients. Clin Chim Acta. 17;429C:175-180, 2013.
  • Toshio Maeda, Ichiro Noge, Yoshiyuki Kagawa. Infiltration of M1 macrophages into adipose tissue of ddY-H mice preceding spontaneous appearances of insulin resistance. Biol Pharm Bull, 36(5):825-32, 2013,
  • Yoshiaki Yamamoto, Yukitoshi Takahashi, Katsumi Imai, Nobuyuki Mishima, Rei Yazawa, Kazuyuki Inoue, Kunihiko Itoh, Yoshiyuki Kagawa, Yushi Inoue. Risk factors for hyperammonemia in pediatric patients with epilepsy, Epilepsia, 54(6):983-9, 2013.
  • Hikaru Satoh, Naohito Ide, Yoshiyuki Kagawa, Toshio Maeda. Hepatic steatosis with relation to increased expression of peroxisome proliferator-activated receptor-γ in insulin resistant mice. Biol Pharm Bull, 36(4):616-23, 2013.
  • Yoshiyuki Kagawa, Toshio Maeda, Yasuhiro Kato, Iori Ueda, Tomoko Kudo, Naoe Watanabe, Midori Kimura, Sato Minami, Tatsuichiro Sakamoto, Hiroshi Yamada, Masakazu Takagi. Influence of the Slow Infusion of a Soybean Oil Emulsion on Plasma Cytokines and Ex Vivo T Cell Proliferation After an Esophagectomy. JPEN J Parenter Enteral Nutr, 2013, 37(1):123-8.
  • Yoshiaki Yamamoto, Yukitoshi Takahashia, Eri Suzuki, Nobuyuki Mishima, Kazuyuki Inoue, Kunihiko Itoh, Yoshiyuki Kagawa, Yushi Inoue. Risk factors for hyperammonemia associated with valproic acid therapy in adult epilepsy patients. Epilepsy Res, 2012, 101(3):202-9.
  • Yoshiaki Yamamoto, Yushi Inoue, Kazumi Matsuda, Yukitoshi Takahashi, Yoshiyuki Kagawa. Influence of Concomitant Antiepileptic Drugs on Plasma Lamotrigine Concentration in Adult Japanese Epilepsy Patients. Biol Pharm Bull, 35 (4), 487-93, 2012.
  • Tuneyoshi Suzuki, Tomonobu Uchino, Yasunori Miyazaki, Yoshiyuki Kagawa. Release profiles of dexamethasone dipropionate from admixtures of steroid and heparinoid ointments prepared by different mixing methods. Chem Pharm Bull, 60(2):260-6, 2012.
  • Takafumi Naito, Masaki Tashiro, Keisuke Yamamoto, Kazunori Ohnishi, Yoshiyuki Kagawa, Junichi Kawakami. Impact of cachexia on pharmacokinetic disposition of and clinical responses to oxycodone in cancer patients. Eur J Clin Pharmacol, 68(10):1411-8, 2012.
  • Masaki Tashiro, Takafumi Naito, Yoshiyuki Kagawa, Junichi Kawakami. Simultaneous determination of prochlorperazine and its metabolites in human plasma using isocratic liquid chromatography tandem mass spectrometry. Biomed Chromatogr. 2012, 26(6): 754-60.
  • Noriyuki Yamamoto, Akira Yoshida, Yuko Taki, Satomi Onoue, Yoshiyuki Kagawa, Shizuo Yamada. Up-regulation of nicotinic and muscarinic receptor mRNA in rat bladder by repeated administration of nicotine in relation to the pharmacokinetics. Life Sciences, 89 , 343–348, 2011.
  • Yasuaki Mino, Takafumi Naito, Atsushi Otsuka, Tatsuya Takayama, Seiichiro Ozono, Yoshiyuki Kagawa, Junichi Kawakami. J. Cyclosporine alters correlation between free and total mycophenolic acid in kidney transplant recipients in the initial phase. J Clin Pharm Ther. 36(2):217-24, 2011.
  • Takafumi Naito, Yoshiaki Takashina, Keisuke Yamamoto, Masaki Tashiro, Kazunori Ohnishi, Yoshiyuki Kagawa, Junichi Kawakami. CYP3A5*3 Affects Plasma Disposition of Noroxycodone and Dose Escalation in Cancer Patients Receiving Oxycodone. J Clin Pharmacol, 51(11):1529-38, 2011.
  • Haruhito Tsutsui, Toshio Maeda, Jun Zhe Min, Shinsuke Inagaki, Tatsuya Higashi, Yoshiyuki Kagawa, Toshimasa Toyo'oka. Biomarker discovery in biological specimens (plasma, hair, liver and kidney) of diabetic mice based upon metabolite profiling using ultra-performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry. Clin Chim Acta, 412(11-12):861-72, 2011.
  • Shingen Misaka, Souhei Kurosawa, Shinya Uchida, Akira Yoshida, Yoshihisa Kato, Yoshiyuki Kagawa, Shizuo Yamada. Evaluation of the pharmacokinetic interaction of midazolam with ursodeoxycholic acid, ketoconazole and dexamethasone by brain benzodiazepine receptor occupancy. J Pharm Pharmacol, 63(1):58-64, 2011.

教育・研究に対する考え方

教育:優れた人格と、欧米でも通用するような問題処理能力を有し、かつ臨床薬学の研究能力を有する三拍子揃った人材を育成する。
研究:臨床の場から研究シーズを探し出し、それを薬学的な切り口から研究し原因を解明して、その成果を臨床の場に再び還元する。

研究シーズ集に関するキーワード

認知症,行動・心理症状(BPSD),アルツハイマー型,ドネペジル,メマンチン

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