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静岡県立大学教員データベース


教員情報詳細


写真:武田 厚司

氏名
武田 厚司(TAKEDA Atsushi)
出生年月
1955年9月
所属・職名
薬学部薬科学科(統合生理学分野) 教授
薬学研究院(統合生理学教室) 教授(兼務)
電話番号
054-264-5733
部屋番号
薬学部棟6516号室
Eメールアドレス
takedaa(ここに@を入れてください)u-shizuoka-ken.ac.jp
ホームページアドレス(URL)
http://w3pharm.u-shizuoka-ken.ac.jp/bioorg/saito/Home.html
研究シーズ集
http://www.u-shizuoka-ken.ac.jp/file/41takeda.pdf

学歴

1978年3月 静岡薬科大学製薬学科卒業
1981年3月 静岡薬科大学大学院薬学研究科修士課程修了


学位

薬学博士(静岡薬科大学・1990年)


専門分野

神経科学、生物無機化学、生理学


担当科目

生物学、機能形態生理学、くらしと化学


主要研究テーマ

・亜鉛シグナリングから視た記憶制御
・アルツハイマー病の病態解析とその予防
・運動障害の病態解析とその予防
・メタロチオネインの生理機能


所属学会

日本神経科学学会
日本薬学会(代議員)
日本微量元素学会(評議員)
日本毒性学会(評議員)
Society for Neuroscience
International Society for Zinc Biology
International Society for Trace Element Research (Councilor)
World Oyster Society (Steering Committee Member)


主な経歴

1981年4月 静岡薬科大学放射薬品学教室 助手
1987年4月 静岡県立大学薬学部放射薬品学教室 助手
1991年4月 静岡県立大学薬学部放射薬品学教室 講師
1992年7月 米国ネブラスカ大学医学部客員研究員(3ヶ月間)
1995年5月 米国ペンシルバニア州立大学医学部客員研究員(1年間)
2000年11月 静岡県立大学薬学部医薬生命化学分野 助教授(2007年4月より准教授)
2012年4月 静岡県立大学薬学部生物薬品学分野(現統合生理学分野) 教授


受賞歴

1997年 日本微量元素学会賞
2004年 日本薬学会学術振興賞


主な社会活動

金属の関与する生体関連反応シンポジウム評議員
メタルバイオサイエンス研究会幹事
メタロミクス研究フォーラム評議員
静岡県大学高専優勝大会理事他


主要研究業績

○原著論文
1. Atsushi Takeda, Yuta koike, Misa Osaw, Haruna Tamano: Characteristic of extracellular Zn2+ influx in the middle-aged dentate gyrus and its involvement in attenuation of LTP. Mol. Neurobiol., in press, DOI: 10.1007/s12035-017-0472-z.
2. Atsushi Takeda, Haruna Tamano, Marie Hisatsune, Taku Murakami, Hiroyuki Nakada, Hiroaki Fujii: Maintained LTP and memory are lost by Zn2+ influx into dentate granule cells, but not Ca2+ influx. Mol. Neurobiol., in press, DOI: 10.1007/s12035-017-0428-3.
3. Yuki Fujise, Mitsuyasu Kubota, Miki Suzuki, Haruna Tamano, Atsushi Takeda: Blockade of intracellular Zn2+ signaling in the basolateral amygdala affects object recognition memory via attenuation of dentate gyrus LTP. Neurochem. Int., in press, DOI; 10.1016/j.neuint.2017.01.014.
4. Haruna Tamano, Ryusuke Nishio, Yukina Shakushi, Miku Sasaki, Yuta koike, Misa Osawa, and Atsushi Takeda: In vitro and in vivo physiology of low nanomolar concentrations of Zn2+ in artificial cerebrospinal fluid. Sci. Rep., 7: 42897 DOI: 10.1038/srep42897 (2017).
5. Haruna Tamano, Kazuki Ide, Paul Anthony Adlard, Ashley Ian Bush, and Atsushi Takeda: Involvement of Hippocampal Excitability in Amyloid β-induced Behavioral and Psychological Symptoms of Dementia. J. Toxicol. Sci., 41, 449-457 (2016).
6. Haruna Tamano, Enya Yusuke, Kazuki Ide, Atsushi Takeda: Influences of Yokukansankachimpihange on aggressive behavior of zinc-deficient mice and actions of the ingredients on excessive neural exocytosis in the hippocampus of zinc-deficient rats. Exp. Anim., 65, 353-361 (2016).
7. Haruna Tamano, Yukina Shakushi, Mitsugu Watanabe, Kazumi Ohashi, Chihiro Uematsu, Tadamune Otsubo, Kiyoshi Ikeda, and Atsushi Takeda: Preventive effect of 3,5-dihydroxy-4-methoxybenzyl alcohol and zinc, Pacific oyster components, on glutamatergic neuron activity in the hippocampus. Biol. Bul., 229, 282-288 (2015).
8. Hiroyuki Yamamoto, Tomohiro Yamane, Kazuaki Iguchi, Kiyotaka Tanaka, Arunasiri Iddamalgoda, Keiko Unno, Minoru Hoshino, Atsushi Takeda: Melanin production through novel processing of proopiomelanocortin in the extracellular compartment of the auricular skin of C57BL/6 mice after UV-irradiation. Sci. Rep., 5, 14579 (2015).
9. Atsushi Takeda, Yukina Shakushi, and Haruna Tamano: Modification of hippocampal excitability in brain slices pretreated with low nanomolar concentration of Zn2+. J. Neurosci. Res., 93, 1641-1647 (2015).
10. Atsushi Takeda, Miki Suzuki, Munekazu Tempaku, Kazumi Ohashi, Haruna Tamano: Influx of extracellular Zn2+ into the hippocampal CA1 neurons is required for cognitive performance via long-term potentiation. Neuroscience, 304, 209-216 (2015).
11. Miki Suzuki, Yuki Fujise, Yuka Tsuchiya, Haruna Tamano, Atsushi Takeda: Excess influx of Zn2+ into dentate granule cells affects object recognition memory via attenuated LTP. Neurochem. Int., 87, 60-65 (2015).
12. Haruna Tamano, Tatsuya Minamino, Hiroaki Fujii, Shunsuke Takada, Masatoshi Nakamura, Masaki Ando, and Atsushi Takeda: Blockade of intracellular Zn2+ signaling in the dentate gyrus erases recognition memory via impairment of maintained LTP. Hippocampus, 25, 952-962 (2015).
13. Atsushi Takeda, Masatoshi Nakamura, Hiroaki Fujii, Chihiro Uematsu, Tatsuya Minamino, Paul A. Adlard, Ashley I. Bush, Haruna Tamano: Amyloid β-mediated Zn2+ influx into dentate granule cells transiently induces a short-term cognitive deficit. PLoS One, 9, e115923 (2014).
14. Atsushi Takeda, Haruna Tamano, Taisuke Ogawa, Shunsuke Takada, Masatoshi Nakamura, Hiroaki Fujii, Masaki Ando: Intracellular Zn2+ signaling in the dentate gyrus is required for object recognition memory. Hippocampus 1404-1412 (2014).
15. Haruna Tamano, Kotaro Fukura, Miki Suzuki, Kazuhiro Sakamoto, Hidehiko Yokogoshi, Atsushi Takeda: Advantageous effect of theanine intake on cognition. Nutri. Neurosci., 17, 279-283 (2014).
16. Hiroyuki Yamamoto, Hiromi Shimokawa, Tatsuomi Haga, Yuki Fukui, Kazuaki Iguchi, Keiko Unno, Minoru Hoshino, Atsushi Takeda: The Expression of Relaxin-3 in Adipose Tissue and its Effects on Adipogenesis. Protein Pept Lett., 21, 517-522 (2014).
17. Akira Minami, Hiroshi, Matsushita, Yuuki Horii, Daisuke Ieno, Yukino Matsuda, Masakazu Saito, Hiroaki Kanazawa, Yuriko Ohyama, Akihiko Wakatsuki, Atsushi Takeda, Kazuya IPJ Hidari, Vilineswary Sabaratnam, Takashi Suzuki: Improvement of Depression-Like Behavior and Memory Impairment with the Ethanol Extract of Pleurotus eryngii in Ovariectomized Rats. Biol. Pharm. Bull., 36: 1990-1995 (2013).
18. Keiko Unno, Naoki Tanida, Naoto Ishii, Hiroyuki Yamamoto, Kazuaki Iguchi, Minoru Hoshino, Atsushi Takeda, Hayato Ozawa, Tsutomu Ohkubo, Lekh R Juneja, Hiroshi Yamada: Anti-stress effect of theanine on students during pharmacy practice: Positive correlation among salivary α-amylase activity, trait anxiety and subjective stress. Pharmacol. Biochem. Behav., 111, 128-135 (2013).
19. Atsushi Takeda, Masashi Iida, Masaki Ando, Masatoshi Nakamura, Haruna Tamano, Naoto Oku: Enhanced susceptibility to spontaneous seizures of Noda epileptic rats by loss of synaptic Zn2+. PLoS One, 8, e71374 (2013).
20. Haruna Tamano, Kotaro Fukura, Miki Suzuki, Kazuhiro Sakamoto, Hidehiko Yokogoshi, Atsushi Takeda: Preventive effect of theanine intake on stress-induced impairments of hippocamapal long-term potentiation and recognition memory. Brain Res. Bull., 95, 1-6 (2013).
21. Hiroyuki Yamamoto, Rina Okada, Kazuaki Iguchi, Satoshi Ohno, Takashi Yokogawa, Kazuya Nishikawa, Keiko Unno, Minoru Hoshino, Atsushi Takeda: Involvement of plasmin-mediated extracellular activation of progalanin in angiogenesis. Biochem. Biophys. Res. Commun., 430, 999-1004 (2013).
22. Atsushi Takeda, Haruka Iwaki, Kazuki Ide, Haruna Tamano and Naoto Oku: Therapeutic effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient and pair-fed mice. Brain Res. Bull., 87, 551-555 (2012).
23. Atsushi Takeda, Miki Suzuki, Haruna Tamano, Shunsuke Takada, Kazuki Ide, Naoto Oku: Involvement of glucocorticoid-mediated Zn2+ signaling in attenuation of hippocampal CA1 LTP by acute stress. Neurochem. Int., 60, 394-399 (2012).
24. Atsushi Takeda, Kosuke Itagaki, Masaki Ando, and Naoto Oku: Involvement of NMDA receptor subunits in zinc-mediated modification of CA1 LTP in the developing hippocampus. J. Neurosci. Res., 90, 551-558 (2012).
25. Atsushi Takeda, Haruna Tamano, Miki Suzuki, Kazuhiro Sakamoto, Naoto Oku, Hidehiko Yokogoshi: Unique induction of CA1 LTP components after intake of theanine, an amino acid in tea leaves and its effect on stress response. Cell. Mol. Neurobiol., 32, 41-48 (2012).
26. Atsushi Takeda, Haruna Tamano, Taisuke Ogawa, Shunsuke Takada, Masaki Ando, Naoto Oku, Mitsugu Watanabe: Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency. Behav. Brain Res., 226, 259-264 (2012).
27. Atsushi Takeda, Shunsuke Takada, Masatoshi Nakamura, Miki Suzuki, Haruna Tamano, Masaki Ando, and Naoto Oku: Transient increase in Zn2+ in hippocampal CA1 pyramidal neurons causes reversible memory deficit. PLoS One, 6, e28615 (2011).
28. Atsushi Takeda, Kazuhiro Sakamoto, Haruna Tamano, Kotaro Fukura, Naoto Inui, Sang Won Suh, Seok-Joon Won, and Hidehiko Yokogoshi: Facilitated neurogenesis in the developing hippocampus after intake of theanine, an amino acid in tea leaves, and object recognition memory. Cell. Mol. Neurobiol., 31, 1079-1088 (2011).
29. Atsushi Takeda, Shunsuke Takada, Masaki Ando, Kosuke Itagaki, Haruna Tamano, Miki Suzuki, Haruka Iwaki, Naoto Oku: Impairment of recognition memory and hippocampal long-term potentiation after acute exposure to clioquinol. Neuroscience, 171, 443-450 (2010).
30. Haruna Tamano, Fumika Kan, Naoto Oku, Atsushi Takeda: Ameliorative effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient young mice. Brain Res. Bull., 83, 351-355 (2010).
31. Masaki Ando, Naoto Oku, Atsushi Takeda: Zinc-mediated attenuation of hippocampal mossy fiber long-term potentiation induced by forskolin. Neurochem. Int., 57, 608-614 (2010).
32. Atsushi Takeda, Miki Suzuki, Haruna Tamano, Masaki Ando, Naoto Oku: Differential effects of zinc influx via AMPA/kainate receptor activation on subsequent induction of hippocampal CA1 LTP components. Brain Res., 1354, 188-195 (2010).
33. Atsushi Takeda, Haruna Tamano, Sachie Imano, Naoto Oku: Increases in extracellular zinc in the amygdala in acquisition and recall of fear experience and their roles in response to fear. Neuroscience, 168, 715-722 (2010).
34. Atsushi Takeda, Haruka Iwaki, Masaki Ando, Kosuke Itagaki, Miki Suzuki, Naoto Oku: Zinc differentially acts on components of long-term potentiation at hippocampal CA1 synapse. Brain Res., 1323, 59-64 (2010).
35. Mitsugu Watanabe, Haruna Tamano, Toshinori Kikuchi, Atsushi Takeda: Susceptibility to stress in young rats after 2-week zinc deprivation. Neurochem. Int., 56, 410-416 (2010).
36. Atsushi Takeda, Masaki Ando, Shingo Kanno, Naoto Oku: Unique response of zinc in the hippocampus to behavioral stress and attenuation of subsequent mossy fiber long-term potentiation. NeuroToxicology, 30, 712-717 (2009).
37. Atsushi Takeda, Naomi Sakurada, Masaki Ando, Shingo Kanno, Naoto Oku: Facilitation of zinc influx via AMPA/kainate receptor activation in the hippocampus. Neurochem. Int., 55, 376-382 (2009).
38. Tomoko Hibino, Mitsutoshi Yuzurihara, Yoshio Kasa and Atsushi Takeda: Synephrine, a component of evodiae fructus, constricts isolated rat aorta via adrenergic and serotonergic receptors. J. Pharmacol. Sci., 111, 73-81 (2009).
39. Sang Won Suh, Seok Joon Won, Aaron M. Hamby, Yang Fan, Christian T. Sheline, Haruna Tamano, Atsushi Takeda and Jialing Liu: Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats. J. Cereb. Blood Flow Metab., 29, 1579-1588 (2009).
40. Haruna Tamano, Fumika Kan, Mika Kawamura, Naoto Oku and Atsushi Takeda: Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation. Neurochem. Int., 55, 536-541 (2009).
41. Atsushi Takeda, Hiromasa Itoh, Haruna Tamano and Naoto Oku: High K+-induced increase in extracellular glutamate in zinc deficiency and endogenous zinc action. J. Health Sci., 55, 405-412 (2009).
42. Tomoko Hibino, Mitsutoshi Yuzurihara, Hitomi Kanno, Yoshio Kasa and Atsushi Takeda: Goshuyuto, a Japanese traditional medicine, and aqueous extracts of Evodiae Fructus constrict isolated rat aorta via adrenergic and/or serotonergic receptors. Biol. Pharm. Bull., 32, 237-241 (2009).
43. Atsushi Takeda, Sayuri Fuke, Masaki Ando, and Naoto Oku: Positive Modulation of Long-term Potentiation at Hippocampal CA1 Synapses by Low Micromolar Concentrations of Zinc. Neuroscience, 158, 585-591 (2009).

○総 説
1. Atsushi Takeda, Haruna Tamano, Ryusuke Nishio, and Taku Murakami: Behavioral abnormality induced by enhanced hypothalamo-pituitary-adrenocortical axis activity under dietary zinc deficiency and its usefulness as models. Int. J. Mol. Sci., 17, 1149 (2016).
2. Atsushi Takeda and Hanuna Tamano: Insight into cognitive decline from Zn2+ dynamics through extracellular signaling of glutamate and glucocorticoids. Arch. Biochem. Biophys., 611, 93-99 (2016).
3. Atsushi Takeda and Hanuna Tamano: Innervation from the entorhinal cortex to the dentate gyrus and the vulnerability to Zn2+. J. Trace Elem. Med. Biol., 38, 19-23 (2016).
4. Hanuna Tamano, Yuta Koike, Hiroyuki Nakada, Yukina Shakushi, and Atsushi Takeda: Significance of synaptic Zn2+ signaling in zincergic and non-zincergic synapses in the hippocampus in cognition. J. Trace Elem. Med. Biol., 38, 93-98 (2016)
5. Atsushi Takeda and Haruna Tamano: Significance of low nanomolar concentration of Zn2+ in artificial cerebrospinal fluid. Mol. Neurobiol., Mar 16, DOI: 10.1007/s12035-016-9816-3 (2016).
6. Atsushi Takeda and Haruna Tamano: Significance of the degree of synaptic Zn2+ signaling in cognition. BioMetals, 29, 177-185 (2016).
7. 武田厚司:記憶と亜鉛シグナル. 内分泌・糖尿病・代謝内科 43, 128-132 (2016).
8. 武田厚司:亜鉛イオンとカルシウムイオンの動態分析から視た脳機能解析. ぶんせき 10, 451-454 (2016).
9. 武田厚司:亜鉛とアミロイドβの相互作用から視た記憶障害とその回避. BIO Clinica 31, 88-89 (2016).
10. 武田厚司, 玉野春南:カキ肉エキスの生理活性成分の機能解析とその有効利用. New Food Industry, 57, 71-75 (2015).
11. Haruna Tamano and Atsushi Takeda: Is interaction of amyloid β-peptides with metals involved in cognitive activity? Metallomics, 7, 1205-1212 (2015).
12. Atsushi Takeda and Haruna Tamano: Regulation of extracellular Zn2+ homeostasis in the hippocampus as a therapeutic target for Alzheimer’s disease. Expert Opin. Ther. Tar., 19, 1-8 (2015).
13. 武田厚司:海馬における亜鉛シグナリング. 亜鉛栄養治療, 5, 37-41 (2014).
14. Atsushi Takeda: Significance of Zn2+ signaling in cognition: insight from synaptic Zn2+ dysfomeostasis. J. Trace Elem. Med. Biol., 28, 393-396 (2014).
15. Atsushi Takeda, Hiroaki Fujii, Tatsuya Minamino, Haruna Tamano: Intracellular Zn2+ signaling in cognition. J. Neurosci. Res., 92, 819-824 (2014).
16. Atsushi Takeda and Haruna Tamano: Cognitive decline due to excess synaptic Zn2+ signaling in the hippocampus. Front. Aging Neurosci., 6, 26 (2014).
17. Atsushi Takeda, Masatoshi Nakamura, Hiroaki Fujii, Haruna Tamano: Synaptic Zn2+ homeostasis and its significance. Metallomics, 5, 417-423 (2013).
18. 飯田雅史, 玉野春南, 武田厚司:鉄, 亜鉛, 銅, セレンの欠乏および過剰と関連する大脳辺縁系病態. (Limbic system pathologies associated with deficiencies and excesses of the trace elements iron, zinc, copper, and selenium. Adriana Torres-Vega et al., Nutri. Rev., 70, 679-692, 2012の和訳)栄養学レビュー 81, 312-328 (2013).
19. Atsushi Takeda and Haruna Tamano: Proposed glucocorticoid-mediated zinc signaling in the hippocampus. Metallomics, 4, 614-618 (2012).
20. Atsushi Takeda: Zinc signaling in the hippocampus and its relation to pathogenesis of depression. J. Trace Elem. Med. Biol., 26, 80-84 (2012).
21. 武田厚司, 神戸大朋:それって亜鉛不足じゃない?. Health & Beauty Review, 28, 31-33 (2012).
22. 武田厚司:ニューロジンクから視た脳機能. ファルマシア, 48, 211-215 (2012).
23. Haruna Tamano and Atsushi Takeda: Dynamic action of neurometals at the synapse. Metallomics, 3, 656-661 (2011).
24. Atsushi Takeda: Zinc signaling in the hippocampus and its relation to pathogenesis of depression. Mol. Neurobiol., 44, 166-174 (2011).
25. Atsushi Takeda: Insight into glutamate excitotoxicity from synaptic zinc homeostasis. Int. J. Alzheimers Dis., 2011, 491597 (2011).
26. Atsushi Takeda and Haruna Tamano: Insight into neurozinc in the hippocampus. Biomed. Res. Trace Elements, 21, 194-203 (2010).
27. Atsushi Takeda and Haruna Tamano: Zinc signaling through glucocorticoid and glutamate signaling in stressful circumstances. J. Neurosci. Res., 88, 3002-3010 (2010).
28. 武田厚司:亜鉛と健康. 健康食品管理士認定協会会報, 5, 9-13 (2010).
29. Atsushi Takeda and Haruna Tamano: Insight into zinc signaling from dietary zinc deficiency. Brain Res. Rev., 62, 33-44 (2009).
30. 武田厚司, 奥 直人:NMDA受容体アンタゴニストとしての亜鉛と海馬LTP. 生体の科学, 60, 356-357 (2009).
31. 武田厚司:海馬グルタミン酸作動性神経に対する抑肝散の作用. 脳21, 12, 20-23 (2009).
32. 武田厚司:亜鉛と脳機能. 臨床検査, 53, 197-201 (2009).

○著 書
1. Atsushi Takeda: Zinc signal in brain functions. "Zinc Signals in Cellular Functions and Disorders" T. Fukada and T. Kanbe eds., Springer (Japan), pp. 161-181, 2014.
2. 武田厚司:亜鉛シグナルからみた脳の健康. "亜鉛の機能と健康", 駒井三千夫, 神戸大朋編, 建帛社(東京), pp.131-150, 2013.


教育・研究に対する考え方

教育:静岡県立大学の学生が静岡県立大学を誇れるよう教育に全力を尽くす
研究:目標達成のために日々前進


研究シーズ集に関するキーワード

記憶制御、アルツハイマー病、うつ病、亜鉛、機能性食品


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