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静岡県立大学教員データベース


教員情報詳細


写真:南 彰

氏名
南 彰(MINAMI Akira)
所属・職名
薬学部薬学科(生化学分野) 講師
薬学研究院(生化学教室) 講師(兼務)
Eメールアドレス
aminami(ここに@を入れてください)u-shizuoka-ken.ac.jp
ホームページアドレス(URL)
http://w3pharm.u-shizuoka-ken.ac.jp/biochem/
研究シーズ集
http://www.u-shizuoka-ken.ac.jp/file/3aminami.pdf

学歴

2000年3月 静岡県立大学薬学部薬学科卒業
2002年3月 静岡県立大学大学院 薬学研究科博士前期課程 製薬学専攻修了
2005年3月 静岡県立大学大学院 薬学研究科博士後期課程 製薬学専攻修了


学位

薬学博士(静岡県立大学・2005年)


専門分野

神経科学、糖鎖生物学、生化学


担当科目

生物系薬学実習Ⅰ・Ⅱ、生化学特論、基礎・医用工学実習、科学演習


主要研究テーマ

・記憶における糖鎖の役割の解明
・糖鎖を標的とした新たな作用機序に基づく神経疾患治療法の確立
・生体内や組織標本で利用できる新たな糖鎖機能解析技術の開発


所属学会

日本薬学会
米国神経科学会
日本生化学会
日本糖質学会
日本女性医学学会
日本神経科学学会


主な経歴

2004年4月 日本学術振興会 特別研究員
2005年4月 静岡県立大学薬学部 客員共同研究員
2005年6月 米国カリフォルニア大学バークレー校 博士研究員
2008年1月 静岡県立大学薬学部 助教 (大学院兼務)
2016年4月 静岡県立大学薬学部 講師 (大学院兼務)


受賞歴

2003年 優秀若手研究者実行委員長賞(衛生薬学・環境トキシコロジーフォーラム )
2010年 財団法人内藤記念科学振興財団ポスター賞(第28回内藤コンファレンス、葉山)
2010年 日本生化学会中部支部奨励賞
2014年 日本薬学会東海支部学術奨励賞
2016年 静岡県立大学学長表彰


主な社会活動

2013年~現在 静岡済生会看護専門学校非常勤講師(兼業)
2008年~現在 糖鎖科学名古屋拠点メンバー
2014年 新学術領域「神経糖鎖生物学」班友
2012, 2013年 日本生化学会中部支部 幹事


主要研究業績

1 Minami A, Meguro Y, Ishibashi S, Ishii A, Shiratori M, Sai S, Horii Y, Shimizu H, Fukumoto H, Shinba S, Taguchi R, Takahashi T, Otsubo T, Ikeda K, Suzuki T. Rapid regulation of sialidase activity in response to neural activity and sialic acid removal during memory processing in rat hippocampus. J. Biol. Chem., in press.
2 Pervin M, Unno K, Nakagawa A, Takahashi Y, Iguchi K, Yamamoto H, Hoshino M, Hara A, Takagaki A, Nanjo F, Minami A, Imai S, Nakamura Y, Blood brain barrier permeability of (−)-epigallocatechin gallate, its proliferation-enhancing activity of human neuroblastoma SH-SY5Y cells, and its preventive effect on age-related cognitive dysfunction in mice. Biochemistry and Biophysics Reports, 9, 180-186 (2017).
3 Minami A, Saito M, Mamada S, Ieno D, Hikita T, Takahashi T, Otsubo T, Ikeda K, Suzuki T. Role of sialidase in long-term potentiation at mossy fiber-CA3 synapses and hippocampus-dependent spatial memory. PLoS One. 11(10), e0165257 (2016).
4 Minami A, Matsushita H, Ieno D, Matsuda Y, Horii Y, Ishii A, Takahashi T, Kanazawa H, Wakatsuki A, Suzuki T. Improvement of neurological disorders in postmenopausal model rats by administration of royal jelly. Climacteric, 19(6), 568-573 (2016).
5 Takahashi T, Unuma S, Kawagishi S, Kurebayashi Y, Takano M, Yoshino H, Minami A, Yamanaka T, Otsubo T, Ikeda K, Suzuki T. Substrate specificity of equine and human influenza A virus sialidase to molecular species of sialic acid. Biol. Pharm. Bull., 39(10), 1728-1733 (2016).
6 Kurebayashi Y, Takahashi T, Tamoto C, Sahara K, Otsubo T, Yokozawa T, Shibahara N, Wada H, Minami A, Ikeda K, Suzuki T. High-efficiency capture of drug resistant-influenza virus by live imaging of sialidase activity. PLoS One, 11(5), e0156400 (2016).
7 Minami A. Highly sensitive histochemical imaging of sialidase activity and role of sialidase in hippocampal memory. Yakugaku Zasshi, 135(12), 1341-1348 (2015).
8 Taguchi R*, Minami A* (*these authors contributed equally), Matsuda Y, Takahashi T, Otsubo T, Ikeda K, Suzuki T. Preferential Accumulation of 14C-N-Glycolylneuraminic Acid over 14C-N-Acetylneuraminic Acid in the Rat Brain after Tail Vein Injection. PLoS ONE, 10, e0131061 (2015).
9 Morii Y, Matsushita H, Minami A, Kanazawa H, Suzuki T, Subhadhirasakul S, Watanabe K, Wakatsuki A. Young Coconut Juice Supplementation Results in Greater Bone Mass and Bone Formation Indices in Ovariectomized Rats: A Preliminary Study. Phytotherapy Research, 29(12), 1950-1955 (2015).
10 Watanabe I, Hikita T, Mizuno H, Sekita R, Minami A, Ishii A, Minamisawa Y, Suzuki K, Maeda H, Hidari KI, Suzuki T. Isolation and characterization of monoclonal antibodies specific for chondroitin sulfate E. Glycobiology, 25, 953-962 (2015).
11 Takahashi T, Takano M, Kurebayashi Y, Agarikuchi T, Suzuki C, Fukushima K, Takahashi S, Otsubo T, Ikeda K, Minami A, Suzuki T. Rapid Fluorescent Detection Assay for Human Parainfluenza Viruses. Biological and Pharmaceutical Bulletin, 38, 1214-1219 (2015).
12 Takahashi T, Agarikuchi T, Kurebayashi Y, Shibahara N, Suzuki C, Kishikawa A, Fukushima K, Takano M, Suzuki F, Wada H, Otsubo T, Ikeda K, Minami A, Suzuki T. Easy and Rapid Detection of Mumps Virus by Live Fluorescent Visualization of Virus-Infected Cells. PLoS ONE, 10, e0144038 (2015).
13 Fukushima K, Takahashi T, Ueyama H, Takaguchi M, Ito S, Oishi K, Minami A, Ishitsubo E, Tokiwa H, Takimoto T, Suzuki T. Amino acid substitutions contributing to alpha2,6-sialic acid linkage binding specificity of human parainfluenza virus type 3 hemagglutinin-neuraminidase. FEBS Letters, 589, 1278-1282 (2015).
14 Minami A, Otsubo T, Ieno D, Ikeda K, Kanazawa H, Shimizu K, Ohata K, Yokochi T, Horii Y, Fukumoto H, Taguchi R, Takahashi T, Oku N, Suzuki T. Visualization of sialidase activity in Mammalian tissues and cancer detection with a novel fluorescent sialidase substrate. PLoS ONE, 9, e81941 (2014).
15 Takahashi T, Otsubo T, Ikeda K, Minami A, Suzuki T. Histochemical imaging of alkaline phosphatase using a novel fluorescent substrate. Biological and Pharmaceutical Bulletin, 37, 1668-1673 (2014).
16 Takano M, Takahashi T, Agarikuchi T, Kurebayashi Y, Minami A, Otsubo T, Ikeda K, Kanazawa H, Suzuki T. Histochemical fluorescent staining of Sendai virus-infected cells with a novel sialidase substrate. Virology, 464-465, 206-212 (2014).
17 Takahashi T, Takano M, Kurebayashi Y, Masuda M, Kawagishi S, Takaguchi M, Yamanaka T, Minami A, Otsubo T, Ikeda K, Suzuki T. N-glycolylneuraminic acid on human epithelial cells prevents entry of influenza A viruses that possess N-glycolylneuraminic acid binding ability. Journal of Virology, 88, 8445-8456 (2014).
18 Takahashi T, Takano M, Agarikuchi T, Kurebayashi Y, Minami A, Otsubo T, Ikeda K, Suzuki T. A novel method for detection of Newcastle disease virus with a fluorescent sialidase substrate. Journal of Virological Methods, 209, 136-142 (2014).
19 Ohyama Y, Matsushita H, Minami A, Kanazawa H, Suzuki T, Watanabe K, Wakatsuki A. Effect of the ethanol extract of Pleurotus eryngii on bone metabolism in ovariectomized rats. Climacteric, 17, 492-499 (2014).
20 Kurebayashi Y, Takahashi T, Otsubo T, Ikeda K, Takahashi S, Takano M, Agarikuchi T, Sato T, Matsuda Y, Minami A, Kanazawa H, Uchida Y, Saito T, Kawaoka Y, Yamada T, Kawamori F, Thomson R, von Itzstein M, Suzuki T. Imaging of influenza virus sialidase activity in living cells. Scientific Reports, 4, 4877 (2014).
21 Fukushima K, Takahashi T, Ito S, Takaguchi M, Takano M, Kurebayashi Y, Oishi K, Minami A, Kato T, Park EY, Nishimura H, Takimoto T, Suzuki T. Terminal sialic acid linkages determine different cell infectivities of human parainfluenza virus type 1 and type 3. Virology, 464-465, 424-431 (2014).
22 Minami A, Matsushita H, Horii Y, Ieno D, Matsuda Y, Saito M, Kanazawa H, Ohyama Y, Wakatsuki A, Takeda A, Hidari KI, Sabaratnam V, Suzuki T. Improvement of depression-like behavior and memory impairment with the ethanol extract of Pleurotus eryngii in ovariectomized rats. Biological and Pharmaceutical Bulletin, 36, 1990-1995 (2013).
23 Minami A, Ishibashi S, Ikeda K, Ishitsubo E, Hori T, Tokiwa H, Taguchi R, Ieno D, Otsubo T, Matsuda Y, Sai S, Inada M, Suzuki T. Catalytic preference of Salmonella typhimurium LT2 sialidase for N-acetylneuraminic acid residues over N-glycolylneuraminic acid residues. FEBS Open Bio, 3, 231-236 (2013).
24 Otsubo T, Minami A, Fujii H, Taguchi R, Takahashi T, Suzuki T, Teraoka F, Ikeda K. 2-(Benzothiazol-2-yl)-phenyl-beta-d-galactopyranoside derivatives as fluorescent pigment dyeing substrates and their application for the assay of beta-d-galactosidase activities. Bioorganic and Medicinal Chemistry Letters, 23, 2245-2249 (2013).
25 Takahashi T, Kawakami T, Mizuno T, Minami A, Uchida Y, Saito T, Matsui S, Ogata M, Usui T, Sriwilaijaroen N, Hiramatsu H, Suzuki Y, Suzuki T. Sensitive and direct detection of receptor binding specificity of highly pathogenic avian influenza A virus in clinical samples. PLoS ONE, 8, e78125 (2013).
26 Minami A, Suzuki T. Distribution of sialidase activity and the role of sialidase in the brain. Trends in Glycoscience and Glycotechnology, 24, 112-121 (2012).
27 Minami A, Shimizu H, Meguro Y, Shibata N, Kanazawa H, Ikeda K, Suzuki T. Imaging of sialidase activity in rat brain sections by a highly sensitive fluorescent histochemical method. Neuroimage, 58, 34-40 (2011).
28 Fukushima K, Takahashi T, Takaguchi M, Ueyama H, Ito S, Kurebayashi Y, Kawanishi T, McKimm-Breschkin JL, Takimoto T, Minami A, Suzuki T. Plaque formation assay for human parainfluenza virus type 1. Biological and Pharmaceutical Bulletin, 34, 996-1000 (2011).
29 Saha RK, Takahashi T, Kurebayashi Y, Fukushima K, Minami A, Kinbara N, Ichitani M, Sagesaka YM, Suzuki T. Antiviral effect of strictinin on influenza virus replication. Antiviral Research, 88, 10-18 (2010).
30 Takeda A, Minami A, Sakurada N, Nakajima S, Oku N. Response of hippocampal mossy fiber zinc to excessive glutamate release. Neurochemistry International, 50, 322-327 (2007).
31 Takeda A, Kannno S, Ando M, Sakurada N, Minami A, Oku N. Unique response of extracelluar zinc in the ventral hippocampus against novelty stress. Neuroscience Research, 58, S164 (2007).
32 Minami A, Xia YF, Zucker RS. Increased Ca2+ influx through Na+/Ca2+ exchanger during long-term facilitation at crayfish neuromuscular junctions. Journal of Physiology, 585, 413-427 (2007).
33 Takeda A, Fuke S, Minami A, Oku N. Role of zinc influx via AMPA/kainate receptor activation in metabotropic glutamate receptor-mediated calcium release. Journal of Neuroscience Research, 85, 1310-1317 (2007).
34 Takeda A, Sakurada N, Kanno S, Minami A, Oku N. Response of extracellular zinc in the ventral hippocampus against novelty stress. Journal of Neurochemistry, 99, 670-676 (2006).
35 Takeda A, Nakajima S, Fuke S, Sakurada N, Minami A, Oku N. Zinc release from Schaffer collaterals and its significance. Brain Research Bulletin, 68, 442-447 (2006).
36 Minami A, Sakurada N, Fuke S, Kikuchi K, Nagano T, Oku N, Takeda A. Inhibition of presynaptic activity by zinc released from mossy fiber terminals during tetanic stimulation. Journal of Neuroscience Research, 83, 167-176 (2006).
37 Takeda A, Yamada K, Minami A, Nagano T, Oku N. Enhanced excitability of hippocampal mossy fibers and CA3 neurons under dietary zinc deficiency. Epilepsy Research, 63, 77-84 (2005).
38 Minami A. Role of synaptotagmin on exocytosis and retrieval of synaptic vesicles. Pharmacia, 40, 765-766 (2004).
39 Takeda A, Minami A, Seki Y, Oku N. Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus. Journal of Neuroscience Research, 75, 225-229 (2004).
40 Takeda A, Minami A, Yamaide R, Oku N. Involvement of amygdalar extracellular zinc in rat behavior for passive avoidance. Neuroscience Letters, 358, 119-122 (2004).
41 Takeda A, Minami A, Seki Y, Nakajima S, Oku N. Release of amino acids by zinc in the hippocampus. Brain Research Bulletin, 63, 253-257 (2004).
42 Takeda A, Minami A, Seki Y, Oku N. Inhibitory function of zinc against excitation of hippocampal glutamatergic neurons. Epilepsy Research, 57, 169-174 (2003).
43 Takeda A, Minami A, Oku N. Neuromodulatory action of zinc in the release of neurotransmitters. Biomedical Research on Trace Elements, 14, 287-289 (2003).
44 Minami A, Takeda A, Yamaide R, Oku N. Relationship between zinc and neurotransmitters released into the amygdalar extracellular space. Brain Research, 936, 91-94 (2002).
45 Minami A, Takeda A, Nishibaba D, Takefuta S, Oku N. Cadmium action in synapses in the brain. Riken Review, 35, 59-63 (2001).
46 Takeda A, Minami A, Takefuta S, Tochigi M, Oku N. Zinc homeostasis in the brain of adult rats fed zinc-deficient diet. Journal of Neuroscience Research, 63, 447-452 (2001).
47 Takeda A, Hirate M, Minami A, Oku N. Enhanced susceptibility to epileptic seizures under zinc deficiency. Neuroscience Research, S25, S164 (2001).
48 Minami A, Takeda A, Oku N. Zinc functions in synapses in the brain. Biomedical Research on Trace Elements, 12, 263-264 (2001).
49 Minami A, Takeda A, Nishibaba D, Takefuta S, Oku N. Cadmium toxicity in synaptic neurotransmission in the brain. Brain Research, 894, 336-339 (2001).
50 Takeda A, Hanajima T, Takefuta S, Minami A, Oku N. Learning and behavior under zinc deficiency. Biomedical Research on Trace Elements, 11, 397-398 (2000).


教育・研究に対する考え方

[教育] 研究を通じて高度な問題解決能力を養い、社会で活躍できる人材を育成する。
[研究] 神経疾患における糖鎖の作用を解明し、創薬を通じて社会に貢献する。また、記憶などの生理機能を糖鎖の視点から明らかにする。


研究シーズ集に関するキーワード

糖鎖、がん、診断、神経疾患、てんかん、アルツハイマー、シアリダーゼ、シアル酸、蛍光イメージング


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