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静岡県立大学教員データベース


教員情報詳細


写真:伊藤 由彦

氏名
伊藤 由彦(ITO Yoshihiko)
出生年月
1976年10月
所属・職名
薬学部薬学科(薬物動態学分野) 講師
薬学研究院(薬物動態学教室) 講師(兼務)
電話番号
054-264-5623
部屋番号
薬学部棟6112号室
Eメールアドレス
y-ito(ここに@を入れてください)u-shizuoka-ken.ac.jp
ホームページアドレス(URL)
http://w3pharm.u-shizuoka-ken.ac.jp/yakuzai/
研究シーズ集
http://www.u-shizuoka-ken.ac.jp/file/25ito.pdf

学歴

2002年3月 静岡県立大学薬学部薬学科卒業
2004年3月 静岡県立大学大学院薬学研究科薬学専攻博士前期課程修了
2007年3月 静岡県立大学大学院薬学研究科医療薬学専攻博士後期課程修了


学位

博士(医療薬学)(静岡県立大学・2007年)


専門分野

薬物動態学、薬効解析学


担当科目

薬剤学、薬物動態学Ⅱ、臨床薬物動態学、医療薬学実習


主要研究テーマ

・医薬品の体内動態と薬効・副作用発現に関する研究
・受容体を標的とした創薬と適正な薬物治療の予測に関する研究
・医薬品と食品の併用効果・相互作用に関する研究


所属学会

日本薬学会
日本薬物動態学会
日本薬理学会
日本薬剤学会
日本臨床薬理学会
日本排尿機能学会
日本泌尿器科学会
国際薬物動態学会(ISSX)
国際尿禁制学会(ICS)


主な経歴

2007年4月 静岡県立大学薬学部医療薬学大講座薬物動態学分野 助教
2014年8月 静岡県立大学薬学部医療薬学大講座薬物動態学分野 講師


主な社会活動

 


主要研究業績

1. Ayaka Osano, Yoshinari Yokoyama, Hideki Hayashi, Kunihiko Itoh, Tkashi Okura, Yoshiharu Deguchi, Yoshihiko Ito, Shizuo Yamada: Endothelin-1 Receptorts in rat tissues: Characterization by Bosentan, Ambrisentan and CI-1020
Biol. Pharm. Bull., 37: 461-465 (2014)
2. Akira Yoshida, Shiori Kuraoka, Yoshihiko Ito, Tkashi Okura, Yoshiharu Deguchi, Atsushi Otsuka, Seiichiro Ozono, Masayuki Takeda, Keisuke Masuyama, Isao Araki, Shizuo Yamada: Muscarinic receptor binding of the novel radioligand [3H]Imidafenacin in the human bladder and parotid gland.
J Pharmacol Sci,, 124: 40-46(2014)
3. Ayaka Osano, Yoshihnari Yokoyama, Hideki Hayashi, Kunio Itoh, Takashi Okura, Yoshiharu Deguchi, Yoshihiko Ito, Shizuo Yamada: Bladder endothelin-1 receptor binding of bosentan and ambrisentan.
J Pharmacol Sci,, 124: 86-91(2014)
4. Sweety Nasrin, Eiji Masuda, Haruna Kugaya, Yoshihito Ito and and Shizuo Yamada: Improvement by phytotherapeutic agent Eviprostat of detrusor overactivity, down-regulation of pharmacological receptors and urinary cytokines in rats with cyclophosphamide-induced cystitis
J.Urol., 189: 1123-1129 (2013)
5. Sweety Nasrin, Eiji Masuda, Haruna Kugaya, Ayaka Osano, Yoshihito Ito and and Shizuo Yamada: Effect of saw palmetto extract on urodynamic parameters, bladder muscarinic and purinergic receptors and urinary cytokines in rats with cyclophosphamide-induced cystitis
LUTS (Lower Urinary Tract Symptoms), 5: 44-51(2013)
6. Sweety Nasrin, Ayaka Osano, Yoshihito Ito and Shizuo Yamada: Beneficial effects of Gosha-jinnki-gan and green tea extract in rats with chemical cystitis
J Pharmacol Sci,, 122: 270-277(2013)
7. Kazuaki Nakada, Mamie Yoshikawa, Soichiro Ide, Akihiro Suemasa, Shuhei Kawamura, Takaaki Kobayashi, Eiji Masuda, Yoshihiko Ito, Wataru Hayakawa, Takahiro Katayama, Shizuo Yamada, Mitsuhiro Arisawa, Masabumi Minami, Satoshi Shuto:Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: Identification of an efficient lead for potent inhibitors of GABA transports.
Bioorg. Med. Chem., 21: 4938-4950(2013)
8. Akira Mizuno, Shiho Miura, Mizuki Watanabe, Yoshihiko Ito, Shizuo Yamada, Takenao Odagami, Yuji Kogami, Mitsuhiro Arisawa, Satoshi Shuto: Three-dimensional structural diversity-oriented peptidomimetics based on the cyclopropylic strain.
Org. Lett., 15: 1686-1689(2013)
9. Mizuki Watanabe, Takaaki Kobayashi, Takatsugu Hirokawa, Akira Yoshida, Yoshihiko Ito, Shizuo Yamada, Naoki Orimoto, Yasundo Yamasaki, Mitsuhiro Arisawa, Satoshi Shuto: Cyclopropane-based stereochemical diversity-oriented conformational restriction strategy: Histamine analogs with the 4-amino-2,3-methano-1-(1H-imidazol-4-yl)butane structure as highly potent histamine H3 and/or H4 receptor ligands.
Org. Biomol. Chem., 10: 736-745 (2012)
10. Yuka Nakano, Yasuo Watanabe, Yoshihiko Ito, Shizuo Yamada and Hiroaki Tokiwa: Novel homodimer model of the β-adrenergic receptor in complex with free fatty acids and cholesterol: first-principles calculation studies.
Bioinformation 8: 1245-1248 (2012)
11. Shizuo Yamada, Masanao Seki, Masaki Ogoda, Ayako Fukata, Miho Nakamura and Yoshihiko Ito: Selective binding of bladder muscarinic receptors in relation to the pharmacokinetics of a novel antimuscarinic agent, imidafenacin, to treat overactive bladder.
J. Pharmacol. Exp. Ther., 336: 365-371 (2011)
12. Shigeyuki Yamamoto, Shuji Maruyama, Yoshihiko Ito, Masahiro Kawamata, Shingo Nishiyama, Hiroyuki Ohba, Shizuo Yamada, Hideo Tsukada: Effect of oxybutynin and imidafenacin on central muscarinic receptor occupancy and cognitive function: a monkey PET study with [(11)C](+)3-MPB.
Neuroimage., 58: 1-9 (2011)
13. Yoshihiko Ito, Aya Kato, Tomomi Fujino (Oki), Takashi Okura, Kenichiro Yoshida, Masato Nanri and Shizuo Yamada: Muscarinic receptor binding and plasma drug concentration after the oral administration of propiverine in mice. LUTS, 2: 43-49 (2010)
14. Shizuo Yamada, Yoshihiko Ito, Yuko Taki, Masanao Seki, Masato Nanri, Fumiaki Yamashita, Kayo Morishima, Ikumi Komoto, and Ken-ichiro Yoshida: The N-oxide metabolite contributes to bladder selectivity resulting from oral propiverine: muscarinic receptor binding and pharmacokinetics. Drug Metab. Dis.. 38: 1314-1321 (2010)
15. Yoshihiko Ito, Taketsugu Harada, Kasumi Fushimi, Yoshiyuki Kagawa, Hidenobu Oka, Hiroshi Nakazawa, Reiko Homma, Yoshihisa Kato and Shizuo Yamada: Pharmacokinetic and phamacodynamic analysis of acetylcholinesterase inhibition by distigmine bromide in rats. Drug Metab. Pharmacokinet., 25: 254-261 (2010)
16 Akira Yoshida, Shuji Maruyama, Dai Fukumoto, Hideo Tsukada, Yoshihiko Ito and Shizuo Yamada: Noninvasive evaluation of brain muscarinic receptor occupancy of oxybutynin, darifenacin and imidafenacin in rats by positron emission tomography. Life Sci., 25: 175-180 (2010)
17. Taketsugu Harada, Kazumi Fushimi, Aya Kato, Yoshihiko Ito, Saori Nishijima, Kimio Sugaya, Shizuo Yamada: Demonstration of muscarinic and nicotinic receptor binding activities of distigmine to treat detrusor underactivity. Biol. Pharm. Bull., 33: 653-658 (2010)
18. Yoshihisa Kato, Hiroshi Suzuki, Koichi Haraguchi, Shinichi Ikushiro, Yoshihiko Ito, Shinya Uchida, Shizuo Yamada and Masakuni Degawa: A possible mechanism for the decrease in serum thyroxin level by phenobarbital in rodents. Toxicol. Appl. Pharmacol., 249: 238-246 (2010)
19. 藤野知美、伊藤由彦、瀧 優子、柿澤希実、尾上誠良、今井康之、奥 直人、野口博司、伊藤邦彦、小林裕和、大橋典男、合田敏尚、木苗直秀、梅垣敬三、渡邉裕司、山田靜雄: WarfarinとビタミンKの相互作用に関する文献的研究. 臨床薬理, 41: 43-52 (2010)
20. 伊藤由彦、吉田 徳、山田静雄: 疾患モデルと排尿障害.糖尿病モデルと排尿. 臨床検査, 54: 799-804(2010)
21. 山田静雄、関 将直、吉田 徳、大古田真輝、伊藤由彦: イミダフェナシンのムスカリン性受容体結合と体内動態からみた有用性.脳21, 13: 46-53 (2010)
22. 吉田 徳、大古田真輝、伊藤由彦、山田靜雄、久保光志、茅野大介、窪田洋子、渡邉泰雄: エノキタケ抽出物含有成分である複合脂肪酸のメタボリック症候群モデルマウス(TSOD)ならびに対照マウス(TSNO)における体内動態の比較. 応用薬理, 78: 21-26 (2010)
23. Yoshihiko Ito, Luvsandorj Oyunzul, Masanao Seki, Tomomi Fujino(Oki), Minoru Matsui and Shizuo Yamada: Quantitative analysis of the loss of muscarinic receptors in various peripheral tissues in M1-M5 single subtype knockout mice. Br. J. Pharmacol., 156, 1147-1153 (2009)
24. Shizuo Yamada, Chihiro Takeuchi, Luvsandorj Oyunzul and Yoshihiko Ito: Bladder angiotensin-II receptors: Characterization and alteration in bladder outlet obstruction.Eur. Urol., 55, 482-489 (2009)
25. Shohei Kurosawa, Shinya Uchida Yoshihiko Ito and Shizuo Yamada: Effect of ursodeoxycholic acid on the pharmacokinetics and midazolam and CYP3A activity in the liver and small intestine of rats. Xenobiotica, 39: 162-170 (2009)
26. Takashi Okura, Yuki Morita, Yoshihiko Ito, Yoshiyuki Kagawa and Shizuo Yamada: Effects of quinidine on antinociception and pharmacokinetics of morphine in rats. J. Pharm. Pharmacol., 61: 593-597 (2009)
27. Masayuki Abe, Yoshihiko Ito, Luvsandorj Oyunzul., Tomomi Oki-Fujino and Shizuo Yamada: Pharmacologically relevant receptor binding characteristics and 5α-reducatase inhibitory activity of free fatty acids contained in Saw palmetto extract. Biol. Pharm. Bull., 32: 646-650 (2009)
28. Masayuki Abe, Yoshihiko Ito, Asahi Suzuki, Satomi Onoue, Hiroshi Noguchi and Shizuo Yamada: Isolation and pharmacological characterization of fatty acids from Saw palmetto extract. Anal. Sci., 25: 553-557 (2009)
29. Yoshihiko Ito, Luvsandorj Oyunzul, Akira Yoshida, Tomomi Fujino, Yukiko Noguchi, Hronori Yuyama, Akiyoshi Ohtake, Masanori Suzuki, Masao Sasamata, Minoru Matsui and Shizuo Yamada: Comparison of muscarinic selectivity of solifenacin and oxybutynin in the bladder and submandibular gland of muscarinic receptor knockout mice. Eur. J. Pharmacol., 615: 201-206 (2009)
30. Yoshihiko Ito, Masanao Seki, Yasuhiko Nishioka, Masatoshi Kimura, Akio Yasuda, Tsukasa Kirimoto, Toshikazu Yasuda and Shizuo Yamada: Pharmacological effects of Hashi-mi-jio-gan extract (Harncare ) on the contractile response and on pharmacologically relevant receptors in the rat bladder. YAKUGAKU ZASSHI, 129: 957-964 (2009)
31. 吉田 徳、萩原えり、伊藤由彦、渡邉泰雄、山田靜雄: 乾燥エノキタケ抽出物のβアドナリン受容体結合活性の評価. 応用薬理 76: 85-90 (2009)
32. Daiki Takahashi, Luvsandorj Oyunzul, Satomi Onoue, Yoshihiko Ito, Shinya Uchida, Rahime Simsek, Miyase Gozde Gunduz, Chiat Safak, and Shizuo Yamada: Structure-activity relationships of receptor binding of 1,4-dihydropyridine derivatives. Biol. Pham. Bull., 31, 473-479 (2008)
33. Aiko Kageyama, Tomomi Fujino, Yuko Taki, Yoshihisa Kato, Yoshihisa Nozawa, Yoshihiko Ito and Shizuo Yamada: Alteration of muscarinic and purinergic receptors in urinary bladder of rats with cyclophosphamide-induced interstitial cystitis. Neurosci. Lett., 436, 81-84 (2008)
34. Takashi Okura, Tadahiro Ozawa, Yoshihiko Ito, Midori Kimura, Yoshiyuki Kagawa and Shizuo Yamada: Enhancement by grapefruit juice of morphine antinociception. Biol. Pharm. Bull., 31, 2338-2341 (2008)
35. 伊藤由彦,影山藍子,石田侑希,吉田 徳,岩崎有作,渡辺達夫,山田静雄: プロピベリンおよびオキシブチニンのバニロイド受容体(TRPV1)に対する作用.日本排尿機能学会誌19, 198-207 (2008)


教育・研究に対する考え方

教育:科学的根拠に基づく判断や論理的な思考をより高めるには何が必要かを考え、「自ら考え、自ら為す」力を養成できるようにしたい。
研究:薬の動き・働きの両面から薬の作用を捉えることで、薬物作用の統合的な理解を深め、よりよい医療の発展に貢献できる研究を行っていきたい。


研究シーズ集に関するキーワード

創薬、機能性食品、受容体、薬物動態、薬効、副作用の解析、排尿障害


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